SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rmf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A  40
GLY A  44
THR A  88
ILE A  86
 None
 0.93A 2f9wA-4rmfA:
undetectable
2f9wB-4rmfA:
undetectable		 2f9wA-4rmfA:
20.78
2f9wB-4rmfA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 120
GLU A 117
GLN A 114
 None
 0.64A 2p16A-4rmfA:
undetectable		 2p16A-4rmfA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 542
VAL A 143
LEU A 151
ILE A 483
ILE A 211
 None
 1.11A 2uxoB-4rmfA:
undetectable		 2uxoB-4rmfA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 VAL A 419
VAL A 420
PHE A 416
ARG A 489
 None
None
None
FMT  A 702 (-2.7A)
 1.31A 3bjwB-4rmfA:
undetectable		 3bjwB-4rmfA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PRO A 563
PHE A 554
LYS A 556
 None
 1.26A 3bjwG-4rmfA:
undetectable		 3bjwG-4rmfA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 406
ARG A 405
PRO A 317
GLY A 319
SER A 321
 None
 1.16A 3bpxA-4rmfA:
undetectable
3bpxB-4rmfA:
0.9		 3bpxA-4rmfA:
15.15
3bpxB-4rmfA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A 127
GLN A 114
GLU A 117
GLU A 550
 None
 1.33A 3dh0A-4rmfA:
undetectable		 3dh0A-4rmfA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 492
GLU A 497
LEU A 518
ASP A 494
 None
 1.43A 4cevA-4rmfA:
undetectable
4cevB-4rmfA:
undetectable		 4cevA-4rmfA:
21.02
4cevB-4rmfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASP A 494
ARG A 492
GLU A 497
LEU A 518
 None
 1.46A 4cevA-4rmfA:
undetectable
4cevC-4rmfA:
undetectable		 4cevA-4rmfA:
21.02
4cevC-4rmfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 492
GLU A 497
LEU A 518
ASP A 494
 None
 1.43A 4cevD-4rmfA:
undetectable
4cevE-4rmfA:
undetectable		 4cevD-4rmfA:
21.02
4cevE-4rmfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 492
GLU A 497
LEU A 518
ASP A 494
 None
 1.46A 4cevE-4rmfA:
undetectable
4cevF-4rmfA:
undetectable		 4cevE-4rmfA:
21.02
4cevF-4rmfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLN A  47
VAL A  49
GLU A  92
ARG A  51
 None
 1.03A 4mv7A-4rmfA:
undetectable		 4mv7A-4rmfA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA A   7
ILE A  86
GLY A  89
ILE A  91
ILE A  37
 None
 1.14A 4nptA-4rmfA:
undetectable		 4nptA-4rmfA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 446
GLY A 485
GLY A 486
ALA A 473
SER A 471
 None
3SY  A 701 ( 3.3A)
FMT  A 702 (-3.2A)
None
None
 1.04A 4qw1K-4rmfA:
undetectable
4qw1L-4rmfA:
undetectable		 4qw1K-4rmfA:
16.55
4qw1L-4rmfA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 266
LEU A 251
PHE A 156
ILE A 476
MET A 233
 None
 1.12A 4x1fA-4rmfA:
undetectable		 4x1fA-4rmfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 266
LEU A 251
PHE A 156
ILE A 476
MET A 233
 None
 1.11A 4x1gA-4rmfA:
undetectable		 4x1gA-4rmfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 531
GLY A 484
ILE A 246
MET A 233
VAL A 250
 None
 1.02A 5n0sA-4rmfA:
undetectable		 5n0sA-4rmfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 531
GLY A 484
ILE A 246
MET A 233
VAL A 250
 None
 0.99A 5n0tA-4rmfA:
undetectable		 5n0tA-4rmfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 531
GLY A 484
ILE A 246
MET A 233
VAL A 250
 None
 0.97A 5n0tB-4rmfA:
undetectable		 5n0tB-4rmfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 531
GLY A 484
ILE A 246
MET A 233
VAL A 250
 None
 1.01A 5n0wB-4rmfA:
undetectable		 5n0wB-4rmfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 531
GLY A 484
ILE A 246
MET A 233
VAL A 250
 None
 1.06A 5n0xA-4rmfA:
undetectable		 5n0xA-4rmfA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 531
GLY A 484
ILE A 246
MET A 233
VAL A 250
 None
 0.98A 5n4iA-4rmfA:
undetectable		 5n4iA-4rmfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A 394
GLY A 338
GLY A 435
LEU A 342
ALA A 334
 None
 1.08A 5o96G-4rmfA:
undetectable
5o96H-4rmfA:
undetectable		 5o96G-4rmfA:
17.21
5o96H-4rmfA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 HIS A 449
SER A 487
TYR A 474
GLY A 486
 FMT  A 702 (-4.3A)
FMT  A 702 ( 4.6A)
None
FMT  A 702 (-3.2A)
 1.00A 5yodH-4rmfA:
undetectable		 5yodH-4rmfA:
16.92