SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 4rml LATROPHILIN-3
(Mus
musculus) 		4 / 7 ARG A 376
ASP A 330
ASP A 275
ARG A 324
 None
TRS  A 602 (-2.7A)
TRS  A 602 (-2.7A)
None
 1.39A 1cebA-4rmlA:
undetectable		 1cebA-4rmlA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		4 / 5 THR A 247
GLU A 291
THR A 293
HIS A 272
 None
 1.40A 1d4fB-4rmlA:
undetectable		 1d4fB-4rmlA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		4 / 5 THR A 247
GLU A 291
THR A 293
HIS A 272
 None
 1.43A 1d4fD-4rmlA:
undetectable		 1d4fD-4rmlA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4rml LATROPHILIN-3
(Mus
musculus) 		3 / 3 TRP A 447
VAL A 435
TRP A 226
 None
 0.71A 1gmkC-4rmlA:
undetectable
1gmkD-4rmlA:
undetectable		 1gmkC-4rmlA:
3.64
1gmkD-4rmlA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4rml LATROPHILIN-3
(Mus
musculus) 		4 / 8 PHE A 299
GLY A 308
LEU A 363
PHE A 288
 None
 1.18A 1gsfA-4rmlA:
undetectable		 1gsfA-4rmlA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4rml LATROPHILIN-3
(Mus
musculus) 		4 / 8 PHE A 299
GLY A 308
LEU A 363
PHE A 288
 None
 1.19A 1gsfB-4rmlA:
undetectable		 1gsfB-4rmlA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4rml LATROPHILIN-3
(Mus
musculus) 		4 / 8 PHE A 299
GLY A 308
LEU A 363
PHE A 288
 None
 1.19A 1gsfD-4rmlA:
undetectable		 1gsfD-4rmlA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rml LATROPHILIN-3
(Mus
musculus) 		4 / 7 PHE A 459
TYR A 389
PRO A 204
GLU A 337
 None
 1.13A 1oniA-4rmlA:
undetectable
1oniB-4rmlA:
undetectable		 1oniA-4rmlA:
18.01
1oniB-4rmlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rml LATROPHILIN-3
(Mus
musculus) 		4 / 7 TYR A 389
PRO A 204
GLU A 337
PHE A 459
 None
 1.10A 1oniG-4rmlA:
undetectable
1oniI-4rmlA:
undetectable		 1oniG-4rmlA:
18.01
1oniI-4rmlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		3 / 3 ARG A 246
ASP A 275
ASP A 332
 None
TRS  A 602 (-2.7A)
MG  A 601 ( 4.6A)
 0.72A 2ejtA-4rmlA:
undetectable		 2ejtA-4rmlA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4rml LATROPHILIN-3
(Mus
musculus) 		3 / 3 ASP A 330
ASN A 289
THR A 247
 TRS  A 602 (-2.7A)
None
None
 0.74A 2pymB-4rmlA:
undetectable		 2pymB-4rmlA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		4 / 8 ILE A 237
TRP A 226
PHE A 217
TYR A 253
 None
 1.30A 3ccfB-4rmlA:
undetectable		 3ccfB-4rmlA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 11 ALA A 334
GLY A 386
ILE A 387
ILE A 353
ILE A 343
 None
 0.89A 3ebzA-4rmlA:
undetectable		 3ebzA-4rmlA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 12 LEU A 444
VAL A 423
VAL A 391
TYR A 389
LEU A 457
 None
 1.20A 3mecA-4rmlA:
undetectable		 3mecA-4rmlA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 9 ALA A 334
GLY A 386
ILE A 387
ILE A 353
ILE A 343
 None
 0.79A 3s43A-4rmlA:
undetectable		 3s43A-4rmlA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 9 ALA A 334
GLY A 386
ILE A 387
ILE A 353
ILE A 343
 None
 0.85A 3s45A-4rmlA:
undetectable		 3s45A-4rmlA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 11 ALA A 334
GLY A 386
ILE A 387
ILE A 353
ILE A 343
 None
 0.82A 3s53B-4rmlA:
undetectable		 3s53B-4rmlA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4rml LATROPHILIN-3
(Mus
musculus) 		3 / 3 TRP A 447
VAL A 435
TRP A 226
 None
 1.09A 3zq8C-4rmlA:
undetectable
3zq8D-4rmlA:
undetectable		 3zq8C-4rmlA:
3.64
3zq8D-4rmlA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 12 VAL A 391
ILE A 407
PRO A 426
TYR A 455
LEU A 444
 None
 1.01A 4pd4C-4rmlA:
undetectable		 4pd4C-4rmlA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 12 LEU A 444
VAL A 423
VAL A 391
TYR A 389
LEU A 457
 None
 1.22A 5cymA-4rmlA:
undetectable		 5cymA-4rmlA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 12 LEU A 444
VAL A 423
VAL A 391
TYR A 389
LEU A 457
 None
 1.22A 5cyqA-4rmlA:
undetectable		 5cyqA-4rmlA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 12 ALA A 334
GLY A 386
ILE A 387
ILE A 353
ILE A 343
 None
 0.82A 5e5jA-4rmlA:
undetectable		 5e5jA-4rmlA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 12 ALA A 334
GLY A 386
ILE A 387
ILE A 353
ILE A 343
 None
 0.81A 5e5kB-4rmlA:
undetectable		 5e5kB-4rmlA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4rml LATROPHILIN-3
(Mus
musculus) 		4 / 5 ASP A 458
ILE A 407
PHE A 425
TYR A 211
 None
 1.22A 6a93B-4rmlA:
undetectable		 6a93B-4rmlA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4rml LATROPHILIN-3
(Mus
musculus) 		5 / 12 LEU A 444
VAL A 423
VAL A 391
TYR A 389
LEU A 457
 None
 1.20A 6eliA-4rmlA:
undetectable		 6eliA-4rmlA:
11.01