SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rmx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 8 PHE A 680
VAL A 702
GLY A 706
GLY A 705
 None
 0.73A 1ekjE-4rmxA:
undetectable
1ekjF-4rmxA:
undetectable		 1ekjE-4rmxA:
15.57
1ekjF-4rmxA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 403
ASP A 349
LEU A 348
LEU A 391
ILE A 404
 None
 0.91A 1ra2A-4rmxA:
undetectable		 1ra2A-4rmxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 403
ASP A 349
LEU A 348
LEU A 391
ILE A 404
 None
 0.90A 1ra3A-4rmxA:
undetectable		 1ra3A-4rmxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 403
ASP A 349
LEU A 348
LEU A 391
ILE A 404
 None
 0.90A 1rb2A-4rmxA:
undetectable		 1rb2A-4rmxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 403
ASP A 349
LEU A 348
LEU A 391
ILE A 404
 None
 0.96A 1rb2B-4rmxA:
undetectable		 1rb2B-4rmxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		6 / 12 ILE A 403
ASP A 349
LEU A 348
ILE A 362
LEU A 391
ILE A 404
 None
 1.22A 1rb3B-4rmxA:
undetectable		 1rb3B-4rmxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 403
ASP A 349
LEU A 348
LEU A 391
ILE A 404
 None
 0.85A 1rd7B-4rmxA:
undetectable		 1rd7B-4rmxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 403
ASP A 349
LEU A 348
LEU A 391
ILE A 404
 None
 0.85A 1rx7A-4rmxA:
undetectable		 1rx7A-4rmxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 5 LYS A 311
PHE A 323
MET A 355
LEU A 363
 None
 1.20A 1skxA-4rmxA:
undetectable		 1skxA-4rmxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 GLY A 319
GLY A 318
LEU A 348
ASP A 349
SER A 280
 None
 1.18A 1xdsA-4rmxA:
undetectable		 1xdsA-4rmxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 403
ASP A 349
LEU A 348
LEU A 391
ILE A 404
 None
 0.91A 2drcA-4rmxA:
undetectable		 2drcA-4rmxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 LEU A 402
TYR A 376
ILE A 362
ILE A 381
ILE A 425
 None
 1.27A 2efjA-4rmxA:
undetectable		 2efjA-4rmxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 5 LEU A 460
ILE A 404
ILE A 389
ALA A 388
 None
 0.74A 2i2zA-4rmxA:
undetectable		 2i2zA-4rmxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 4 LEU A 460
ILE A 404
ILE A 389
ALA A 388
 None
 0.85A 2i30A-4rmxA:
undetectable		 2i30A-4rmxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 384
TYR A 360
GLY A 424
GLY A 422
VAL A 453
 None
 0.96A 2qe6B-4rmxA:
undetectable		 2qe6B-4rmxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 403
ASP A 349
LEU A 348
LEU A 391
ILE A 404
 None
 0.91A 3drcA-4rmxA:
undetectable		 3drcA-4rmxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 8 GLY A 556
ILE A 638
CYH A 643
PHE A 615
 None
 0.87A 3ko0K-4rmxA:
undetectable
3ko0S-4rmxA:
undetectable		 3ko0K-4rmxA:
11.52
3ko0S-4rmxA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 403
LEU A 348
ILE A 362
LEU A 391
ILE A 404
 None
 0.97A 4fhbA-4rmxA:
undetectable		 4fhbA-4rmxA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 ILE A 403
ASP A 349
LEU A 348
ILE A 362
LEU A 391
 None
 1.14A 4gh8A-4rmxA:
undetectable		 4gh8A-4rmxA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		3 / 3 TYR A 324
ARG A 375
SER A 351
 None
 1.12A 4khpI-4rmxA:
undetectable
4khpJ-4rmxA:
undetectable		 4khpI-4rmxA:
11.45
4khpJ-4rmxA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 11 ILE A 403
ASP A 349
LEU A 348
LEU A 391
ILE A 404
 None
 0.90A 4p66A-4rmxA:
undetectable		 4p66A-4rmxA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		3 / 3 THR A 768
ASN A 769
SER A 770
 None
 0.72A 4tvtA-4rmxA:
undetectable		 4tvtA-4rmxA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 4 ASN A 392
SER A 430
ALA A 428
VAL A 427
 SR  A 907 ( 4.6A)
None
None
None
 1.10A 4x1kC-4rmxA:
undetectable		 4x1kC-4rmxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 4 ASN A 392
SER A 430
ALA A 428
VAL A 462
 SR  A 907 ( 4.6A)
None
None
None
 1.30A 4x1kC-4rmxA:
undetectable		 4x1kC-4rmxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 5 ILE A 470
VAL A 492
ILE A 522
VAL A 502
 None
 0.73A 4xdtA-4rmxA:
undetectable		 4xdtA-4rmxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 GLY A 368
ILE A 381
LEU A 391
HIS A 397
THR A 367
 None
 1.24A 4zdyA-4rmxA:
undetectable		 4zdyA-4rmxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 6 GLY A 658
ASP A 657
ARG A 662
GLY A 660
 None
 0.84A 5cdnA-4rmxA:
undetectable
5cdnB-4rmxA:
undetectable		 5cdnA-4rmxA:
20.72
5cdnB-4rmxA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 6 GLY A 658
ASP A 657
ARG A 662
GLY A 660
 None
 0.88A 5cdnC-4rmxA:
undetectable
5cdnD-4rmxA:
undetectable		 5cdnC-4rmxA:
20.72
5cdnD-4rmxA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 6 GLY A 658
ASP A 657
ARG A 662
GLY A 660
 None
 0.88A 5cdnT-4rmxA:
undetectable
5cdnU-4rmxA:
undetectable		 5cdnT-4rmxA:
20.72
5cdnU-4rmxA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 6 GLY A 658
ASP A 657
ARG A 662
GLY A 660
 None
 0.87A 5cdpA-4rmxA:
undetectable
5cdpB-4rmxA:
undetectable		 5cdpA-4rmxA:
19.94
5cdpB-4rmxA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 6 LEU A 317
ILE A 251
TRP A 284
MET A 304
 None
 1.44A 5ljeA-4rmxA:
undetectable		 5ljeA-4rmxA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		3 / 3 ILE A 362
ASN A 451
CYH A 459
 None
 0.76A 6bp4A-4rmxA:
undetectable		 6bp4A-4rmxA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 12 GLY A 368
ILE A 381
LEU A 391
HIS A 397
THR A 367
 None
 1.23A 6e8qA-4rmxA:
undetectable		 6e8qA-4rmxA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		4 / 5 ALA A 559
TYR A 610
GLN A 498
ILE A 536
 None
 1.14A 6g9bA-4rmxA:
undetectable
6g9bB-4rmxA:
undetectable		 6g9bA-4rmxA:
9.20
6g9bB-4rmxA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4rmx PHI92_GP150
(Enterobacteria
phage
phi92) 		5 / 11 THR A 800
PHE A 798
THR A 675
THR A 690
ILE A 669
 None
 1.35A 6hcoA-4rmxA:
undetectable
6hcoB-4rmxA:
undetectable		 6hcoA-4rmxA:
20.93
6hcoB-4rmxA:
20.93