SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4rn3 HAD SUPERFAMILY
HYDROLASE
(Geobacter
sulfurreducens) 		5 / 12 LEU A 154
LEU A 179
GLU A 175
LEU A 195
ILE A  14
 None
 1.06A 1s9pC-4rn3A:
undetectable		 1s9pC-4rn3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4rn3 HAD SUPERFAMILY
HYDROLASE
(Geobacter
sulfurreducens) 		5 / 12 PHE A 135
LEU A 103
ILE A 207
THR A 116
VAL A 171
 None
 1.17A 2g78A-4rn3A:
undetectable		 2g78A-4rn3A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)		 4rn3 HAD SUPERFAMILY
HYDROLASE
(Geobacter
sulfurreducens) 		5 / 10 LEU A 131
LEU A 126
MET A 122
TYR A  15
THR A 116
 None
 1.33A 2idkA-4rn3A:
0.6
2idkB-4rn3A:
0.5
2idkC-4rn3A:
0.6
2idkD-4rn3A:
0.5		 2idkA-4rn3A:
23.91
2idkB-4rn3A:
23.91
2idkC-4rn3A:
23.91
2idkD-4rn3A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4rn3 HAD SUPERFAMILY
HYDROLASE
(Geobacter
sulfurreducens) 		5 / 10 TYR A  15
PHE A  99
MET A  95
LEU A 126
LEU A 131
 None
 1.44A 2w98A-4rn3A:
4.3		 2w98A-4rn3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4rn3 HAD SUPERFAMILY
HYDROLASE
(Geobacter
sulfurreducens) 		5 / 12 ILE A 207
ALA A   9
ALA A 198
ALA A  12
VAL A  13
 None
 0.99A 3jb3A-4rn3A:
undetectable		 3jb3A-4rn3A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4rn3 HAD SUPERFAMILY
HYDROLASE
(Geobacter
sulfurreducens) 		3 / 3 GLY A 164
PRO A 165
ALA A 184
 None
 0.50A 4qn9B-4rn3A:
undetectable		 4qn9B-4rn3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4rn3 HAD SUPERFAMILY
HYDROLASE
(Geobacter
sulfurreducens) 		3 / 3 ASP A 104
SER A 133
TYR A 134
 None
 0.86A 5glmA-4rn3A:
undetectable		 5glmA-4rn3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4rn3 HAD SUPERFAMILY
HYDROLASE
(Geobacter
sulfurreducens) 		3 / 3 ARG A 200
PRO A 194
TYR A 191
 None
 1.08A 5tzoB-4rn3A:
undetectable		 5tzoB-4rn3A:
20.69