SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rn7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		5 / 12 ILE A 148
LEU A 283
VAL A 235
ILE A 208
ILE A 194
 None
 0.98A 1oipA-4rn7A:
undetectable		 1oipA-4rn7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		4 / 7 ARG A 213
ALA A 216
ILE A 258
ILE A 242
 EPE  A 403 (-3.9A)
EPE  A 403 (-3.7A)
None
None
 0.77A 1oniD-4rn7A:
undetectable
1oniF-4rn7A:
undetectable		 1oniD-4rn7A:
24.43
1oniF-4rn7A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		4 / 7 THR A 266
GLU A 271
THR A 267
VAL A 237
 None
 1.15A 1tv8A-4rn7A:
undetectable		 1tv8A-4rn7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		4 / 8 THR A 266
GLU A 271
THR A 267
VAL A 237
 None
 1.12A 2fb2A-4rn7A:
undetectable		 2fb2A-4rn7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		4 / 7 THR A 266
GLU A 271
THR A 267
VAL A 237
 None
 1.16A 2fb2B-4rn7A:
undetectable		 2fb2B-4rn7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		4 / 5 LEU A 223
GLY A 290
ILE A 260
ILE A 258
 None
 0.74A 2q9rA-4rn7A:
undetectable		 2q9rA-4rn7A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		4 / 8 GLY A 124
ASN A 145
ILE A 208
SER A 193
 None
 0.94A 2yoeB-4rn7A:
undetectable
2yoeC-4rn7A:
undetectable		 2yoeB-4rn7A:
21.43
2yoeC-4rn7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		5 / 12 VAL A 249
LEU A 176
ILE A 174
GLY A 124
SER A 193
 None
 1.21A 3kk6B-4rn7A:
undetectable		 3kk6B-4rn7A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		5 / 12 GLN A 159
VAL A 288
ILE A 287
PRO A 256
ILE A 258
 None
 1.21A 4drhD-4rn7A:
undetectable		 4drhD-4rn7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		3 / 3 ASP A 143
ASP A 171
ASN A 128
 None
 0.75A 4q5mA-4rn7A:
undetectable		 4q5mA-4rn7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		5 / 12 SER A 193
VAL A 165
ALA A 180
THR A 118
ALA A 257
 None
None
None
FMT  A 406 ( 3.7A)
None
 1.26A 4x1kA-4rn7A:
undetectable
4x1kB-4rn7A:
3.9		 4x1kA-4rn7A:
18.89
4x1kB-4rn7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		4 / 4 LEU A 152
LEU A 283
GLY A 286
GLU A 285
 None
 0.98A 5hhjA-4rn7A:
undetectable		 5hhjA-4rn7A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
(Clostridioides
difficile) 		4 / 8 ILE A 258
GLY A 290
THR A 226
LEU A 292
 None
None
None
GOL  A 402 ( 4.5A)
 0.83A 5hwaA-4rn7A:
undetectable		 5hwaA-4rn7A:
22.73