SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rnh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A1267
ILE A1266
LEU A1279
GLY A1221
ALA A1226
 None
 1.20A 1e7aA-4rnhA:
undetectable		 1e7aA-4rnhA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 LYS A1244
ASP A1310
ASP A1333
 None
MG  A1501 ( 2.6A)
None
 0.95A 2br4A-4rnhA:
undetectable		 2br4A-4rnhA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 TYR A1321
ALA A1293
MET A1294
LEU A1297
 None
 0.87A 2wekB-4rnhA:
undetectable		 2wekB-4rnhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 TYR A1143
ALA A1078
ASN A1148
LEU A1152
PHE A1140
 None
 1.14A 3qxyA-4rnhA:
undetectable		 3qxyA-4rnhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 11 TYR A1143
ALA A1078
ASN A1148
LEU A1152
PHE A1140
 None
 1.13A 3rc0A-4rnhA:
undetectable		 3rc0A-4rnhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 TYR A1143
ALA A1078
ASN A1148
LEU A1152
PHE A1140
 None
 1.13A 3rc0B-4rnhA:
undetectable		 3rc0B-4rnhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1065
LEU A1015
PHE A1061
ILE A1085
ALA A1082
 None
 1.04A 3uwlB-4rnhA:
undetectable		 3uwlB-4rnhA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 11 ILE A1266
ILE A1263
GLY A1260
VAL A1247
GLN A1253
 None
None
None
None
C2E  A1503 (-4.0A)
 1.08A 4ac9B-4rnhA:
2.8
4ac9C-4rnhA:
3.1		 4ac9B-4rnhA:
22.67
4ac9C-4rnhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1297
LEU A1300
ILE A1307
ASN A1248
LEU A1286
 None
None
None
C2E  A1503 ( 2.8A)
None
 0.96A 4lmnA-4rnhA:
undetectable		 4lmnA-4rnhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 986
LEU A1063
VAL A1039
ALA A1040
ILE A1085
 None
 0.93A 4x1yD-4rnhA:
undetectable		 4x1yD-4rnhA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 986
LEU A1063
VAL A1039
ALA A1040
ILE A1085
 None
 0.95A 4x20B-4rnhA:
undetectable		 4x20B-4rnhA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 THR A1041
LEU A1043
ALA A1040
LEU A1017
GLY A1032
 None
 1.07A 4xi3C-4rnhA:
undetectable		 4xi3C-4rnhA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 ARG A1077
VAL A1047
ASP A1050
ASP A1051
 None
 1.09A 4xqgA-4rnhA:
undetectable		 4xqgA-4rnhA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 ARG A1077
VAL A1047
ASP A1050
ASP A1051
 None
 1.08A 4xqgB-4rnhA:
undetectable		 4xqgB-4rnhA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 11 GLU A1189
GLN A1177
GLU A1367
GLY A1388
GLY A1368
 MG  A1501 ( 2.9A)
None
C2E  A1503 (-3.3A)
C2E  A1503 (-3.3A)
C2E  A1503 (-3.4A)
 1.28A 5e3iB-4rnhA:
undetectable		 5e3iB-4rnhA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 11 ILE A1263
GLY A1260
ASP A1256
LEU A1277
VAL A1247
 None
 1.29A 5hw4B-4rnhA:
undetectable		 5hw4B-4rnhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4rnh MOTILITY REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1065
LEU A1015
PHE A1061
ILE A1085
ALA A1082
 None
 1.09A 5j7wD-4rnhA:
undetectable		 5j7wD-4rnhA:
21.17