SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rnr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.06A 1zzrA-4rnrB:
undetectable
1zzrB-4rnrB:
undetectable		 1zzrA-4rnrB:
19.49
1zzrB-4rnrB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.08A 1zzrA-4rnrB:
undetectable
1zzrB-4rnrB:
undetectable		 1zzrA-4rnrB:
19.49
1zzrB-4rnrB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.05A 1zzuA-4rnrB:
undetectable
1zzuB-4rnrB:
undetectable		 1zzuA-4rnrB:
19.49
1zzuB-4rnrB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.06A 1zzuA-4rnrB:
undetectable
1zzuB-4rnrB:
undetectable		 1zzuA-4rnrB:
19.49
1zzuB-4rnrB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B  75
THR B  74
PHE B  62
ARG B  54
 None
 1.27A 2kotA-4rnrB:
undetectable		 2kotA-4rnrB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4rnr PGT130 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.43A 2y03A-4rnrA:
undetectable		 2y03A-4rnrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4rnr PGT130 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.46A 2y03B-4rnrA:
undetectable		 2y03B-4rnrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.10A 3dqrA-4rnrB:
undetectable
3dqrB-4rnrB:
undetectable		 3dqrA-4rnrB:
19.39
3dqrB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.14A 3dqrA-4rnrB:
undetectable
3dqrB-4rnrB:
undetectable		 3dqrA-4rnrB:
19.39
3dqrB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4rnr PGT130 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU A 189
GLY A 190
ALA A 125
PRO A 126
 None
 0.50A 3huoA-4rnrA:
undetectable		 3huoA-4rnrA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.04A 3jx2A-4rnrB:
undetectable
3jx2B-4rnrB:
undetectable		 3jx2A-4rnrB:
19.39
3jx2B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.06A 3jx2A-4rnrB:
undetectable
3jx2B-4rnrB:
undetectable		 3jx2A-4rnrB:
19.39
3jx2B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.07A 3jx3A-4rnrB:
undetectable
3jx3B-4rnrB:
undetectable		 3jx3A-4rnrB:
19.39
3jx3B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.07A 3jx3A-4rnrB:
undetectable
3jx3B-4rnrB:
undetectable		 3jx3A-4rnrB:
19.39
3jx3B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.11A 3jx4A-4rnrB:
undetectable
3jx4B-4rnrB:
undetectable		 3jx4A-4rnrB:
19.39
3jx4B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.06A 3jx5A-4rnrB:
undetectable
3jx5B-4rnrB:
undetectable		 3jx5A-4rnrB:
19.39
3jx5B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.09A 3jx5A-4rnrB:
undetectable
3jx5B-4rnrB:
undetectable		 3jx5A-4rnrB:
19.39
3jx5B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 0.99A 3jx6A-4rnrB:
undetectable
3jx6B-4rnrB:
undetectable		 3jx6A-4rnrB:
19.39
3jx6B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.04A 3jx6A-4rnrB:
undetectable
3jx6B-4rnrB:
undetectable		 3jx6A-4rnrB:
19.39
3jx6B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4rnr PGT130 HEAVY CHAIN
PGT130 LIGHT CHAIN
(Homo
sapiens) 		5 / 12 PHE A 166
VAL B 195
VAL B 144
PRO B 113
PHE B 139
 None
 1.41A 3nbrA-4rnrA:
undetectable		 3nbrA-4rnrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.00A 3nljA-4rnrB:
undetectable
3nljB-4rnrB:
undetectable		 3nljA-4rnrB:
19.39
3nljB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.06A 3nljA-4rnrB:
undetectable
3nljB-4rnrB:
undetectable		 3nljA-4rnrB:
19.39
3nljB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.04A 3nlpA-4rnrB:
undetectable
3nlpB-4rnrB:
undetectable		 3nlpA-4rnrB:
19.39
3nlpB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.09A 3nlpA-4rnrB:
undetectable
3nlpB-4rnrB:
undetectable		 3nlpA-4rnrB:
19.39
3nlpB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 8 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 0.99A 3nlqA-4rnrB:
undetectable
3nlqB-4rnrB:
undetectable		 3nlqA-4rnrB:
19.39
3nlqB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.06A 3nlqA-4rnrB:
undetectable
3nlqB-4rnrB:
undetectable		 3nlqA-4rnrB:
19.39
3nlqB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.04A 3nlrA-4rnrB:
undetectable
3nlrB-4rnrB:
undetectable		 3nlrA-4rnrB:
19.39
3nlrB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 8 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.06A 3nlrA-4rnrB:
undetectable
3nlrB-4rnrB:
undetectable		 3nlrA-4rnrB:
19.39
3nlrB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4rnr PGT130 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.43A 3nyaA-4rnrA:
undetectable		 3nyaA-4rnrA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.07A 4cx3A-4rnrB:
undetectable
4cx3B-4rnrB:
undetectable		 4cx3A-4rnrB:
19.39
4cx3B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.07A 4cx3A-4rnrB:
undetectable
4cx3B-4rnrB:
undetectable		 4cx3A-4rnrB:
19.39
4cx3B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.08A 4cx4A-4rnrB:
undetectable
4cx4B-4rnrB:
undetectable		 4cx4A-4rnrB:
19.39
4cx4B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.08A 4cx4A-4rnrB:
undetectable
4cx4B-4rnrB:
undetectable		 4cx4A-4rnrB:
19.39
4cx4B-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4rnr PGT130 HEAVY CHAIN
PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PHE B  98
PHE A 100
ASN A  60
GLY A  49
 None
 0.90A 4ejjA-4rnrB:
undetectable		 4ejjA-4rnrB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4rnr PGT130 HEAVY CHAIN
PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PHE B  98
PHE A 100
ASN A  60
GLY A  49
 None
 1.02A 4ejjB-4rnrB:
undetectable		 4ejjB-4rnrB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 4rnr PGT130 HEAVY CHAIN
(Homo
sapiens) 		5 / 10 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.45A 4ldoA-4rnrA:
undetectable		 4ldoA-4rnrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 4 THR B  26
GLY B  93
ASP B  95
SER B  27
 None
 1.37A 4rfqA-4rnrB:
undetectable		 4rfqA-4rnrB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.02A 5addA-4rnrB:
undetectable
5addB-4rnrB:
undetectable		 5addA-4rnrB:
19.39
5addB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.04A 5adeA-4rnrB:
undetectable
5adeB-4rnrB:
undetectable		 5adeA-4rnrB:
19.39
5adeB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 106
ARG B  61
VAL B  19
GLU B  83
 None
 1.07A 5g0pA-4rnrB:
undetectable
5g0pB-4rnrB:
undetectable		 5g0pA-4rnrB:
19.39
5g0pB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU B  83
VAL B 106
ARG B  61
VAL B  19
 None
 1.10A 5g0pA-4rnrB:
undetectable
5g0pB-4rnrB:
undetectable		 5g0pA-4rnrB:
19.39
5g0pB-4rnrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4rnr PGT130 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU B 132
ALA B 130
LEU B 178
THR B 181
 None
 1.02A 5l4iA-4rnrB:
undetectable		 5l4iA-4rnrB:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4rnr PGT130 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL A 207
THR A 205
VAL A 211
GLY A 118
VAL A 152
 None
 1.00A 6drzA-4rnrA:
undetectable		 6drzA-4rnrA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4rnr PGT130 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.41A 6h7mB-4rnrA:
undetectable		 6h7mB-4rnrA:
14.93