SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		5 / 12 LEU A 142
GLY A 145
LEU A 138
PHE A 151
ARG A 100
 None
 0.88A 1dfoA-4rnsA:
undetectable		 1dfoA-4rnsA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		5 / 12 LEU A 142
GLY A 145
LEU A 138
SER A 146
ARG A 100
 None
 1.05A 1dfoD-4rnsA:
undetectable		 1dfoD-4rnsA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		5 / 12 LEU A 142
GLY A 145
LEU A 138
SER A 146
PHE A 151
 None
 1.07A 1dfoD-4rnsA:
undetectable		 1dfoD-4rnsA:
18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		3 / 3 PRO A  92
THR A 122
PRO A 124
 None
 0.70A 2d55C-4rnsA:
undetectable		 2d55C-4rnsA:
54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		4 / 6 ARG A 134
GLY A 130
THR A 129
ARG A 100
 None
 1.12A 2f7fA-4rnsA:
undetectable		 2f7fA-4rnsA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		6 / 7 PRO A  92
SER A  95
PHE A  99
PRO A 287
GLY A 288
TRP A 291
 None
 0.36A 2y7kA-4rnsA:
25.9		 2y7kA-4rnsA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		5 / 5 SER A  95
ARG A  97
PRO A 287
GLY A 288
TRP A 291
 None
 0.56A 2y7kB-4rnsA:
25.4		 2y7kB-4rnsA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		5 / 12 GLY A 107
GLY A 152
PHE A 167
PRO A 248
ARG A 250
 None
 0.73A 2y7kC-4rnsA:
24.6		 2y7kC-4rnsA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		5 / 12 GLY A 107
PHE A 151
PHE A 167
PRO A 248
ARG A 250
 None
 1.20A 2y7kC-4rnsA:
24.6		 2y7kC-4rnsA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		5 / 6 SER A  95
ARG A  97
PRO A 287
GLY A 288
TRP A 291
 None
 0.63A 2y7pA-4rnsA:
18.2		 2y7pA-4rnsA:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		5 / 12 ILE A 101
LEU A 115
ILE A 299
MET A 111
VAL A 275
 None
 1.06A 2ygnA-4rnsA:
undetectable		 2ygnA-4rnsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		4 / 5 LEU A 270
ILE A 247
PRO A 248
PHE A 231
 None
 1.11A 3s3vA-4rnsA:
undetectable		 3s3vA-4rnsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		5 / 12 ILE A 273
ARG A 168
GLU A 209
ASN A 205
GLY A 153
 None
 1.33A 5il1A-4rnsA:
undetectable		 5il1A-4rnsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		4 / 5 ALA A 201
VAL A 207
PHE A 231
ILE A 273
 None
 1.05A 5of1B-4rnsA:
undetectable		 5of1B-4rnsA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN
(Sphingobium
chlorophenolicum) 		5 / 9 VAL A 275
LEU A 166
ILE A 101
LEU A 142
MET A 111
 None
 1.22A 5og9A-4rnsA:
undetectable		 5og9A-4rnsA:
19.83