SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		3 / 3 TRP A 165
ALA A 115
VAL A 161
 None
 0.86A 1c4dC-4rnxA:
undetectable
1c4dD-4rnxA:
undetectable		 1c4dC-4rnxA:
3.75
1c4dD-4rnxA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 8 ASN A  56
GLN A  49
ASN A 388
TRP A 368
 None
 1.24A 1rs7B-4rnxA:
undetectable		 1rs7B-4rnxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 LEU A 275
ILE A 270
VAL A 206
PHE A 133
HIS A 135
 None
 1.38A 2qo4A-4rnxA:
undetectable		 2qo4A-4rnxA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 7 VAL A  23
LYS A  27
ILE A  30
GLY A  33
 None
 0.83A 3bjwB-4rnxA:
undetectable		 3bjwB-4rnxA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 7 VAL A  23
LYS A  27
ILE A  30
GLY A  33
 None
 0.79A 3bjwF-4rnxA:
undetectable		 3bjwF-4rnxA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 7 VAL A  23
LYS A  27
ILE A  30
GLY A  33
 None
 0.83A 3bjwH-4rnxA:
undetectable		 3bjwH-4rnxA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 8 ASN A  56
GLN A  49
ASN A 388
TRP A 368
 None
 1.29A 3n62B-4rnxA:
undetectable		 3n62B-4rnxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		6 / 11 VAL A 134
LEU A  91
LEU A 136
VAL A 117
GLY A 119
ALA A 118
 None
 1.33A 3pghB-4rnxA:
undetectable		 3pghB-4rnxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		6 / 12 VAL A 134
LEU A  91
LEU A 136
VAL A 117
GLY A 119
ALA A 118
 None
 1.32A 3pghC-4rnxA:
undetectable		 3pghC-4rnxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		6 / 12 VAL A 134
LEU A  91
LEU A 136
VAL A 117
GLY A 119
ALA A 118
 None
 1.33A 3pghD-4rnxA:
undetectable		 3pghD-4rnxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 VAL A 134
LEU A 136
VAL A 117
GLY A 119
ALA A 118
 None
 1.07A 3rr3A-4rnxA:
undetectable		 3rr3A-4rnxA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 VAL A 134
LEU A 136
VAL A 117
GLY A 119
ALA A 118
 None
 1.07A 3rr3C-4rnxA:
undetectable		 3rr3C-4rnxA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 VAL A 134
LEU A 136
VAL A 117
GLY A 119
ALA A 118
 None
 1.07A 3rr3D-4rnxA:
undetectable		 3rr3D-4rnxA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		3 / 3 HIS A  54
SER A 384
ASN A 388
 None
 0.77A 3s8pB-4rnxA:
undetectable		 3s8pB-4rnxA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		6 / 7 THR A 285
TRP A 364
HIS A  40
ASN A  43
TYR A  45
TYR A 224
 FMN  A 501 (-3.7A)
FMN  A 501 ( 4.9A)
FMN  A 501 (-3.5A)
FMN  A 501 (-4.2A)
None
FMN  A 501 ( 4.8A)
 0.59A 4a3uA-4rnxA:
6.7		 4a3uA-4rnxA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 7 THR A 285
HIS A  40
ASN A  43
TYR A  45
TYR A 224
 FMN  A 501 (-3.7A)
FMN  A 501 (-3.5A)
FMN  A 501 (-4.2A)
None
FMN  A 501 ( 4.8A)
 0.61A 4a3uB-4rnxA:
19.6		 4a3uB-4rnxA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 7 THR A 285
TRP A 364
HIS A  40
ASN A  43
TYR A  45
 FMN  A 501 (-3.7A)
FMN  A 501 ( 4.9A)
FMN  A 501 (-3.5A)
FMN  A 501 (-4.2A)
None
 0.25A 4a3uB-4rnxA:
19.6		 4a3uB-4rnxA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 7 THR A 285
TRP A 364
HIS A  40
ASN A  43
TYR A  45
 FMN  A 501 (-3.7A)
FMN  A 501 ( 4.9A)
FMN  A 501 (-3.5A)
FMN  A 501 (-4.2A)
None
 0.32A 4awuA-4rnxA:
7.2		 4awuA-4rnxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 6 THR A 285
HIS A  40
TYR A  45
TYR A 224
 FMN  A 501 (-3.7A)
FMN  A 501 (-3.5A)
None
FMN  A 501 ( 4.8A)
 0.78A 4df2A-4rnxA:
7.6		 4df2A-4rnxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 6 TYR A 330
HIS A  40
TYR A  45
TYR A 224
 None
FMN  A 501 (-3.5A)
None
FMN  A 501 ( 4.8A)
 1.06A 4df2A-4rnxA:
7.6		 4df2A-4rnxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 VAL A 134
LEU A  91
VAL A 117
GLY A 119
ALA A 118
 None
 1.08A 4otyA-4rnxA:
undetectable		 4otyA-4rnxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 4 GLU A 152
GLY A 149
HIS A 178
ARG A 140
 None
 1.46A 4r82A-4rnxA:
undetectable
4r82B-4rnxA:
undetectable		 4r82A-4rnxA:
18.95
4r82B-4rnxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 ALA A  34
SER A  29
GLY A  85
GLY A  90
LEU A 363
 None
 1.30A 4uilH-4rnxA:
undetectable
4uilL-4rnxA:
undetectable		 4uilH-4rnxA:
20.63
4uilL-4rnxA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 11 ALA A 321
VAL A 359
ASP A  35
SER A  29
GLY A  33
 None
 0.81A 4xp4A-4rnxA:
undetectable		 4xp4A-4rnxA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 ALA A 369
GLY A 367
GLY A 328
ALA A 385
LEU A  47
 None
 0.96A 5c0oG-4rnxA:
2.1		 5c0oG-4rnxA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		3 / 3 HIS A  54
SER A 384
ASN A 388
 None
 0.74A 5cprB-4rnxA:
undetectable		 5cprB-4rnxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 LEU A 363
GLN A 362
GLY A  90
ASN A  43
VAL A 365
 None
FMN  A 501 (-3.0A)
None
FMN  A 501 (-4.2A)
None
 1.33A 5d0yA-4rnxA:
undetectable		 5d0yA-4rnxA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		8 / 8 THR A 285
TRP A 364
HIS A  40
ASN A  43
TYR A  45
PHE A  99
PRO A 144
TYR A 224
 FMN  A 501 (-3.7A)
FMN  A 501 ( 4.9A)
FMN  A 501 (-3.5A)
FMN  A 501 (-4.2A)
None
None
None
FMN  A 501 ( 4.8A)
 0.50A 5v4vA-4rnxA:
30.0		 5v4vA-4rnxA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		8 / 8 THR A 285
TRP A 364
HIS A  40
ASN A  43
TYR A  45
PHE A  99
PRO A 144
TYR A 224
 FMN  A 501 (-3.7A)
FMN  A 501 ( 4.9A)
FMN  A 501 (-3.5A)
FMN  A 501 (-4.2A)
None
None
None
FMN  A 501 ( 4.8A)
 0.51A 5v4vB-4rnxA:
30.0		 5v4vB-4rnxA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 8 LEU A  93
ILE A 164
ALA A  70
LEU A  74
 None
 0.78A 5y7pC-4rnxA:
undetectable		 5y7pC-4rnxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 4 GLY A 329
ARG A 377
ASN A 374
LEU A 375
 None
 1.23A 6b58A-4rnxA:
undetectable		 6b58A-4rnxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 5 LEU A 192
THR A 314
ARG A  92
ARG A 197
 None
None
FMN  A 501 (-2.9A)
FMN  A 501 (-3.8A)
 1.41A 6ew0B-4rnxA:
undetectable		 6ew0B-4rnxA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 5 LEU A 192
THR A 314
ARG A  92
ARG A 197
 None
None
FMN  A 501 (-2.9A)
FMN  A 501 (-3.8A)
 1.41A 6ew0D-4rnxA:
undetectable		 6ew0D-4rnxA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 5 LEU A 192
THR A 314
ARG A  92
ARG A 197
 None
None
FMN  A 501 (-2.9A)
FMN  A 501 (-3.8A)
 1.41A 6ew0I-4rnxA:
undetectable		 6ew0I-4rnxA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4rnx NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 ASP A 159
ASN A 158
PHE A 160
PRO A 139
GLY A 173
 None
None
None
None
FMN  A 501 (-3.6A)
 1.35A 6gnfA-4rnxA:
undetectable		 6gnfA-4rnxA:
22.26