SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 PHE A 168
MET A 159
THR A 139
LEU A 137
 None
 1.26A 1ea1A-4rnzA:
undetectable		 1ea1A-4rnzA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 HIS A 217
GLU A 225
ALA A 223
HIS A 365
 None
 1.13A 1errA-4rnzA:
undetectable
1errB-4rnzA:
undetectable		 1errA-4rnzA:
20.41
1errB-4rnzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 106
ILE A 108
ILE A 100
ILE A 102
PHE A 121
 None
 0.84A 2ygoA-4rnzA:
undetectable		 2ygoA-4rnzA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 HIS A 339
HIS A 306
ASP A 263
HIS A 341
 None
None
ZN  A 501 (-2.1A)
ZN  A 501 (-3.1A)
 1.01A 3c0zA-4rnzA:
undetectable		 3c0zA-4rnzA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 6 HIS A 339
HIS A 306
ASP A 263
HIS A 341
 None
None
ZN  A 501 (-2.1A)
ZN  A 501 (-3.1A)
 1.02A 3c0zC-4rnzA:
undetectable		 3c0zC-4rnzA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		3 / 3 GLU A 385
HIS A 406
HIS A 407
 None
NI  A 502 ( 3.3A)
NI  A 503 ( 3.3A)
 0.91A 3co4A-4rnzA:
undetectable		 3co4A-4rnzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 10 TYR A 264
THR A 233
LEU A 354
GLY A 355
VAL A 344
 None
 1.31A 3lxiA-4rnzA:
undetectable		 3lxiA-4rnzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 11 TYR A 264
THR A 233
LEU A 354
GLY A 355
VAL A 344
 None
 1.29A 3lxiB-4rnzA:
undetectable		 3lxiB-4rnzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		3 / 3 HIS A 390
HIS A 408
HIS A 406
 NI  A 502 ( 3.4A)
NI  A 502 (-3.2A)
NI  A 502 ( 3.3A)
 0.34A 3qpkA-4rnzA:
undetectable		 3qpkA-4rnzA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		3 / 3 HIS A 390
HIS A 408
HIS A 406
 NI  A 502 ( 3.4A)
NI  A 502 (-3.2A)
NI  A 502 ( 3.3A)
 0.36A 3qpkB-4rnzA:
undetectable		 3qpkB-4rnzA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 4 LYS A 163
GLN A 157
ILE A 351
LEU A 231
 None
 1.42A 3qt0A-4rnzA:
undetectable		 3qt0A-4rnzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 7 TRP A  46
LEU A  55
LEU A  64
ILE A 108
 None
 1.03A 3u5jA-4rnzA:
undetectable		 3u5jA-4rnzA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 HIS A 268
GLY A 269
ALA A 266
SER A 270
 None
 0.86A 3u9hA-4rnzA:
undetectable		 3u9hA-4rnzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 HIS A 268
GLY A 269
ALA A 266
SER A 270
 None
 0.82A 3u9hB-4rnzA:
undetectable		 3u9hB-4rnzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 HIS A 268
GLY A 269
ALA A 266
SER A 270
 None
 0.85A 4bjcA-4rnzA:
undetectable		 4bjcA-4rnzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 10 HIS A 339
HIS A 306
ASP A 263
HIS A 341
PRO A 258
 None
None
ZN  A 501 (-2.1A)
ZN  A 501 (-3.1A)
None
 1.28A 4bz6A-4rnzA:
undetectable		 4bz6A-4rnzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 HIS A 339
HIS A 306
ASP A 263
HIS A 341
PRO A 258
 None
None
ZN  A 501 (-2.1A)
ZN  A 501 (-3.1A)
None
 1.27A 4bz6A-4rnzA:
undetectable
4bz6B-4rnzA:
undetectable		 4bz6A-4rnzA:
20.71
4bz6B-4rnzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 HIS A 339
HIS A 306
ASP A 263
HIS A 341
PRO A 258
 None
None
ZN  A 501 (-2.1A)
ZN  A 501 (-3.1A)
None
 1.25A 4bz6C-4rnzA:
undetectable		 4bz6C-4rnzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 10 HIS A 339
HIS A 306
ASP A 263
HIS A 341
PRO A 258
 None
None
ZN  A 501 (-2.1A)
ZN  A 501 (-3.1A)
None
 1.27A 4bz6D-4rnzA:
undetectable		 4bz6D-4rnzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 9 TYR A 264
THR A 233
LEU A 354
GLY A 355
VAL A 344
 None
 1.23A 4c9kA-4rnzA:
undetectable		 4c9kA-4rnzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 7 HIS A 268
GLY A 269
ALA A 266
SER A 270
 None
 0.80A 4hyfA-4rnzA:
undetectable		 4hyfA-4rnzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 HIS A 268
GLY A 269
ALA A 266
SER A 270
 None
 0.79A 4hyfB-4rnzA:
undetectable		 4hyfB-4rnzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 HIS A 268
GLY A 269
ALA A 266
SER A 270
 None
 0.82A 4hyfC-4rnzA:
undetectable		 4hyfC-4rnzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		3 / 3 VAL A 293
GLY A 284
LYS A 291
 None
 0.79A 4k50I-4rnzA:
undetectable		 4k50I-4rnzA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 GLY A 355
ILE A 357
ILE A 351
LEU A 302
ILE A 272
 None
 1.07A 4pd4C-4rnzA:
undetectable		 4pd4C-4rnzA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		3 / 3 ARG A 183
ASP A 184
ARG A 128
 GOL  A 508 ( 3.8A)
None
None
 0.63A 4wq4B-4rnzA:
undetectable		 4wq4B-4rnzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		3 / 3 HIS A 390
HIS A 408
HIS A 406
 NI  A 502 ( 3.4A)
NI  A 502 (-3.2A)
NI  A 502 ( 3.3A)
 0.29A 5migA-4rnzA:
undetectable		 5migA-4rnzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 LEU A 171
ALA A 199
VAL A 172
TYR A 208
 None
 1.00A 5nu7A-4rnzA:
undetectable		 5nu7A-4rnzA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 ALA A  98
ASN A  58
LEU A  95
GLY A  53
LEU A  68
 None
 1.24A 5x24A-4rnzA:
undetectable		 5x24A-4rnzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 10 ALA A  98
LEU A  55
TYR A  85
THR A  87
LEU A  51
 None
 0.92A 6f5uA-4rnzA:
undetectable
6f5uB-4rnzA:
undetectable		 6f5uA-4rnzA:
13.24
6f5uB-4rnzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 6 ILE A 295
TYR A 304
VAL A 320
SER A 276
 None
 1.23A 6f6jA-4rnzA:
undetectable		 6f6jA-4rnzA:
undetectable