SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ro1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4ro1 DIS3-LIKE
EXONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU B 656
VAL B 476
VAL B 536
GLY B 477
LEU B 608
 None
 1.47A 1fk9A-4ro1B:
undetectable		 1fk9A-4ro1B:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4ro1 DIS3-LIKE
EXONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU B 656
VAL B 476
VAL B 536
GLY B 477
LEU B 608
 None
 1.20A 1lwfA-4ro1B:
undetectable		 1lwfA-4ro1B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4ro1 DIS3-LIKE
EXONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU B 514
ILE B 775
ARG B 770
ILE B 769
 None
 0.80A 2q8hA-4ro1B:
undetectable		 2q8hA-4ro1B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4ro1 DIS3-LIKE
EXONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU B 407
ASN B 405
SER B 818
PHE B 822
 None
 1.49A 3i9jB-4ro1B:
undetectable		 3i9jB-4ro1B:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ro1 DIS3-LIKE
EXONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 7 GLU B 663
HIS B 664
VAL B 536
ALA B 657
 None
 1.02A 3kp6B-4ro1B:
2.4		 3kp6B-4ro1B:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ro1 DIS3-LIKE
EXONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		3 / 3 PRO B 635
ASP B 630
GLU B 829
 None
 0.89A 3v4tC-4ro1B:
undetectable		 3v4tC-4ro1B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 4ro1 DIS3-LIKE
EXONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 9 ARG B 562
LEU B 460
ALA B 481
ASP B 482
LEU B 518
 None
 1.35A 3wsjA-4ro1B:
undetectable		 3wsjA-4ro1B:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4ro1 DIS3-LIKE
EXONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU B 408
GLY B 412
VAL B 814
SER B 811
VAL B 504
 None
 1.16A 4qd3A-4ro1B:
undetectable		 4qd3A-4ro1B:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4ro1 DIS3-LIKE
EXONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 4 ARG B 659
GLU B 663
GLU B 546
ARG B 550
 None
 0.83A 6fk2A-4ro1B:
undetectable		 6fk2A-4ro1B:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 4ro1 DIS3-LIKE
EXONUCLEASE 2
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS B 803
ASN B 805
TYR B 740
GLU B 809
 None
 1.48A 6gneA-4ro1B:
undetectable		 6gneA-4ro1B:
20.50