SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ro5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 4ro5 SAT DOMAIN FROM CAZM
(Chaetomium
globosum) 		5 / 11 SER A 367
VAL A  23
GLY A 153
LEU A  18
VAL A 237
 None
None
None
None
GOL  A 402 ( 4.9A)
 1.41A 1i9jH-4ro5A:
undetectable
1i9jL-4ro5A:
undetectable		 1i9jH-4ro5A:
20.79
1i9jL-4ro5A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4ro5 SAT DOMAIN FROM CAZM
(Chaetomium
globosum) 		5 / 12 PHE A  19
ALA A 161
ALA A 165
TYR A 313
ARG A 355
 None
 1.36A 1kt5A-4ro5A:
undetectable		 1kt5A-4ro5A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4ro5 SAT DOMAIN FROM CAZM
(Chaetomium
globosum) 		5 / 12 LEU A 338
ALA A 336
LEU A 158
LEU A 159
ILE A 191
 None
 1.08A 3olsB-4ro5A:
undetectable		 3olsB-4ro5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4ro5 SAT DOMAIN FROM CAZM
(Chaetomium
globosum) 		3 / 3 HIS A 382
ARG A 366
GLU A 365
 None
None
GOL  A 402 (-3.7A)
 1.19A 3qf1A-4ro5A:
0.0		 3qf1A-4ro5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4ro5 SAT DOMAIN FROM CAZM
(Chaetomium
globosum) 		4 / 5 ASP A 388
LEU A 122
ILE A 391
PRO A 392
 None
 1.09A 3s3vA-4ro5A:
undetectable		 3s3vA-4ro5A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4ro5 SAT DOMAIN FROM CAZM
(Chaetomium
globosum) 		5 / 12 LEU A 107
TYR A 116
VAL A 162
GLY A 177
PHE A 173
 None
 1.10A 3sglA-4ro5A:
undetectable		 3sglA-4ro5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 4ro5 SAT DOMAIN FROM CAZM
(Chaetomium
globosum) 		5 / 12 ALA A 253
SER A 255
LEU A 229
ILE A 225
VAL A 267
 None
 1.37A 5vlmB-4ro5A:
undetectable		 5vlmB-4ro5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4ro5 SAT DOMAIN FROM CAZM
(Chaetomium
globosum) 		5 / 12 GLY A 153
GLY A 157
ALA A 156
LEU A  18
PRO A 369
 None
None
GOL  A 401 (-3.5A)
None
None
 1.15A 6b3bA-4ro5A:
undetectable		 6b3bA-4ro5A:
22.00