SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4roa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4roa SERPIN 2
(Anopheles
gambiae) 		5 / 12 LEU A 297
PHE A 386
PHE A 388
PRO A 407
TYR A 251
 None
 1.10A 1drfA-4roaA:
undetectable		 1drfA-4roaA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 4roa SERPIN 2
(Anopheles
gambiae) 		5 / 12 LEU A 330
ALA A  70
LEU A 191
LEU A  64
THR A  98
 None
 1.40A 2aa6B-4roaA:
undetectable		 2aa6B-4roaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 7 ARG A 384
LEU A 262
PHE A 260
PHE A 380
 None
 0.96A 2eimP-4roaA:
undetectable
2eimW-4roaA:
undetectable		 2eimP-4roaA:
20.50
2eimW-4roaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4roa SERPIN 2
(Anopheles
gambiae) 		5 / 12 LEU A 330
ALA A  70
LEU A 191
LEU A  64
THR A  98
 None
 1.44A 2oaxF-4roaA:
undetectable		 2oaxF-4roaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4roa SERPIN 2
(Anopheles
gambiae) 		3 / 3 LEU A 262
ASN A 381
ARG A 384
 None
 0.76A 2qhfA-4roaA:
undetectable		 2qhfA-4roaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4roa SERPIN 2
(Anopheles
gambiae) 		5 / 12 SER A 305
PHE A 125
ILE A 163
ASN A 164
HIS A 170
 None
 1.36A 2vdyA-4roaA:
39.6		 2vdyA-4roaA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 7 ARG A 384
LEU A 262
PHE A 260
PHE A 380
 None
 0.99A 3ag2C-4roaA:
undetectable		 3ag2C-4roaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 7 ARG A 384
LEU A 262
PHE A 260
PHE A 380
 None
 0.99A 3ag2P-4roaA:
undetectable
3ag2W-4roaA:
undetectable		 3ag2P-4roaA:
20.50
3ag2W-4roaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 7 ARG A 384
LEU A 262
PHE A 260
PHE A 380
 None
 1.04A 3asoP-4roaA:
undetectable
3asoW-4roaA:
undetectable		 3asoP-4roaA:
20.50
3asoW-4roaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 6 GLY A 357
TYR A 361
GLY A 199
ASN A 354
 None
 0.89A 3e9rA-4roaA:
undetectable		 3e9rA-4roaA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 6 GLY A 357
TYR A 361
GLY A 199
ASN A 354
 None
 0.88A 3e9rC-4roaA:
undetectable		 3e9rC-4roaA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4roa SERPIN 2
(Anopheles
gambiae) 		5 / 11 LEU A 191
THR A 190
VAL A 342
LEU A 312
PHE A  41
 None
 1.09A 3tbgA-4roaA:
undetectable		 3tbgA-4roaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4roa SERPIN 2
(Anopheles
gambiae) 		5 / 10 LEU A 191
THR A 190
VAL A 342
LEU A 312
PHE A  41
 None
 1.09A 3tbgC-4roaA:
undetectable		 3tbgC-4roaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 6 ARG A 384
LEU A 262
PHE A 260
PHE A 380
 None
 1.08A 3wg7C-4roaA:
undetectable
3wg7J-4roaA:
undetectable		 3wg7C-4roaA:
20.50
3wg7J-4roaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM0_B_KANB302_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4roa SERPIN 2
(Anopheles
gambiae) 		5 / 11 LEU A  66
THR A  65
TYR A 144
LEU A 106
VAL A  89
 None
 1.43A 4em0B-4roaA:
0.1		 4em0B-4roaA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4roa SERPIN 2
(Anopheles
gambiae) 		5 / 12 LEU A 297
PHE A 386
PHE A 388
PRO A 407
TYR A 251
 None
 1.08A 4m6kA-4roaA:
undetectable		 4m6kA-4roaA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 4roa SERPIN 2
(Anopheles
gambiae) 		3 / 3 MET A 258
GLN A 245
TYR A 236
 None
 1.10A 4udcA-4roaA:
undetectable		 4udcA-4roaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 4 VAL A 132
ILE A 189
ASN A 123
VAL A 151
 None
 1.20A 5ajqA-4roaA:
undetectable		 5ajqA-4roaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4roa SERPIN 2
(Anopheles
gambiae) 		5 / 12 PRO A 204
GLY A 199
ARG A 252
PHE A 197
LEU A 249
 None
 1.07A 5fa8A-4roaA:
undetectable		 5fa8A-4roaA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 8 PRO A  57
MET A 398
LEU A 273
ILE A 276
 None
 0.98A 5ieoA-4roaA:
1.4		 5ieoA-4roaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 6 ARG A 384
LEU A 262
PHE A 260
PHE A 380
 None
 1.04A 5x19P-4roaA:
undetectable		 5x19P-4roaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4roa SERPIN 2
(Anopheles
gambiae) 		4 / 5 ARG A 384
LEU A 262
PHE A 260
PHE A 380
 None
 1.07A 5x1bP-4roaA:
undetectable		 5x1bP-4roaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4roa SERPIN 2
(Anopheles
gambiae) 		5 / 11 ILE A 387
ALA A 401
LEU A  39
LEU A 242
ILE A 261
 None
 0.84A 5z6mA-4roaA:
undetectable		 5z6mA-4roaA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4roa SERPIN 2
(Anopheles
gambiae) 		3 / 3 PHE A 304
ASP A 303
LYS A 348
 None
 0.87A 6awtD-4roaA:
undetectable		 6awtD-4roaA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 4roa SERPIN 2
(Anopheles
gambiae) 		3 / 3 TYR A 259
PRO A 250
LEU A 249
 None
 0.95A 6beoA-4roaA:
undetectable		 6beoA-4roaA:
3.15