SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4roe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 169
LEU A 172
VAL A 173
VAL A 217
LEU A 269
 None
 1.17A 1db1A-4roeA:
undetectable		 1db1A-4roeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 123
PHE A 149
GLY A 136
ALA A 137
LEU A 172
 None
 1.08A 1fe2A-4roeA:
undetectable		 1fe2A-4roeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 159
LEU A 160
LEU A 162
GLN A 128
LEU A 117
 None
 1.43A 1sqnA-4roeA:
undetectable		 1sqnA-4roeA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 159
LEU A 160
LEU A 162
GLN A 128
LEU A 117
 None
 1.44A 2w8yB-4roeA:
undetectable		 2w8yB-4roeA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 119
CYH A 120
ALA A 100
LEU A 162
VAL A 164
 None
 0.93A 3adsB-4roeA:
undetectable		 3adsB-4roeA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 119
CYH A 120
ALA A 100
LEU A 162
VAL A 164
 None
 0.92A 3adxB-4roeA:
undetectable		 3adxB-4roeA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		4 / 6 THR A 227
SER A 246
ASP A 257
THR A 230
 None
 1.12A 3q70A-4roeA:
undetectable		 3q70A-4roeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 156
ILE A 106
ALA A 100
VAL A  76
LEU A  79
 None
 1.29A 3s79A-4roeA:
undetectable		 3s79A-4roeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 210
ILE A 297
VAL A 293
ALA A 271
LEU A 269
 None
 1.27A 4m11A-4roeA:
undetectable		 4m11A-4roeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 210
ILE A 297
VAL A 293
LEU A 300
LEU A 269
 None
 1.20A 4m11A-4roeA:
undetectable		 4m11A-4roeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		4 / 7 ILE A 156
PHE A 149
GLY A 119
MET A 135
 None
 0.85A 4zdzA-4roeA:
1.6		 4zdzA-4roeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 ILE A 156
PHE A 149
GLY A 119
MET A 135
 None
 0.86A 5esjA-4roeA:
undetectable		 5esjA-4roeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 156
ILE A 106
ALA A 100
VAL A  76
LEU A  79
 None
 1.26A 5jkvA-4roeA:
undetectable		 5jkvA-4roeA:
21.00