SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		5 / 10 GLY A  47
SER A 123
MET A 124
LEU A 207
HIS A 234
 None
 0.76A 1a8uB-4rotA:
13.7		 1a8uB-4rotA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		5 / 12 TYR A 166
GLY A  47
SER A 123
GLY A 147
LEU A 207
 None
 1.13A 1igxA-4rotA:
undetectable		 1igxA-4rotA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		4 / 7 TYR A 166
TRP A  81
TYR A 127
GLY A 121
 None
 1.33A 1mxgA-4rotA:
undetectable		 1mxgA-4rotA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		5 / 12 ILE A   6
ALA A   5
LEU A  99
PHE A 106
PHE A 107
 None
 1.37A 1y0xX-4rotA:
undetectable		 1y0xX-4rotA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		5 / 12 TYR A  82
GLY A 121
GLY A 125
TYR A 127
LEU A  42
 None
 1.05A 3vywA-4rotA:
undetectable		 3vywA-4rotA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4rot ESTERASE A
(Streptococcus
pyogenes) 		3 / 3 ASP A  38
LYS A  37
ASP A  36
 None
 0.68A 4a7tA-4rotA:
undetectable		 4a7tA-4rotA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		4 / 6 ASN A 240
ARG A 259
TYR A 254
LEU A 247
 None
 1.34A 4f8yA-4rotA:
2.7
4f8yB-4rotA:
undetectable		 4f8yA-4rotA:
22.30
4f8yB-4rotA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		5 / 12 LEU A  45
GLY A 121
LEU A 246
VAL A  72
THR A  59
 None
 1.21A 4olmA-4rotA:
undetectable		 4olmA-4rotA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		5 / 12 ALA A 129
GLY A 147
GLY A 126
GLY A  47
ALA A 199
 None
 1.18A 5c0oE-4rotA:
undetectable		 5c0oE-4rotA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		4 / 4 LEU A  65
TYR A 141
PRO A  40
ILE A  71
 None
 1.13A 5esgA-4rotA:
undetectable		 5esgA-4rotA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		5 / 11 THR A 195
VAL A 245
LEU A 246
ALA A 133
GLN A 242
 None
 1.35A 6dryA-4rotA:
undetectable		 6dryA-4rotA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 4rot ESTERASE A
(Streptococcus
pyogenes) 		4 / 5 ILE A  22
SER A   3
ALA A  60
LEU A 243
 None
 0.94A 6dwnA-4rotA:
undetectable		 6dwnA-4rotA:
16.34