SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rpc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		4 / 5 HIS A 238
LEU A 183
LEU A 142
GLY A  28
 None
 1.02A 1a4lB-4rpcA:
undetectable		 1a4lB-4rpcA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 115
SER A 224
ILE A 223
LEU A 191
ILE A 104
 None
 1.01A 1draA-4rpcA:
undetectable		 1draA-4rpcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		4 / 6 SER A 203
ILE A 256
ALA A  88
ALA A 103
 None
 0.84A 1w0gA-4rpcA:
undetectable		 1w0gA-4rpcA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 MET A 155
ASP A 162
LEU A 147
ILE A 170
PHE A  29
 None
 1.41A 1xomA-4rpcA:
undetectable		 1xomA-4rpcA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 9 GLY A  26
ALA A  27
SER A  93
LEU A  94
HIS A 238
 None
 0.79A 1y7iA-4rpcA:
14.3		 1y7iA-4rpcA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 9 GLY A  26
SER A  93
LEU A  94
TYR A 187
HIS A 238
 None
 1.27A 1y7iA-4rpcA:
14.3		 1y7iA-4rpcA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 9 GLY A  26
SER A  93
TYR A 187
PHE A 138
HIS A 238
 None
 1.34A 1y7iA-4rpcA:
14.3		 1y7iA-4rpcA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 115
SER A 224
ILE A 223
LEU A 191
ILE A 104
 None
 1.00A 2drcA-4rpcA:
undetectable		 2drcA-4rpcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 10 MET A  64
ARG A 176
ALA A 135
LEU A 179
ALA A 178
 None
 1.50A 2wseB-4rpcA:
undetectable		 2wseB-4rpcA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 9 MET A  64
ARG A 176
ALA A 135
LEU A 179
ALA A 178
 None
 1.50A 2wsfB-4rpcA:
undetectable		 2wsfB-4rpcA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		4 / 6 SER A  93
ARG A 188
GLY A 122
GLU A 125
 None
 1.14A 3k9fA-4rpcA:
undetectable
3k9fB-4rpcA:
undetectable
3k9fD-4rpcA:
3.8		 3k9fA-4rpcA:
19.05
3k9fB-4rpcA:
19.05
3k9fD-4rpcA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 115
SER A 224
ILE A 223
LEU A 191
ILE A 104
 None
 1.01A 3tq9A-4rpcA:
undetectable		 3tq9A-4rpcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 115
SER A  97
SER A 224
ILE A 223
LEU A 191
 None
 0.85A 4ky8A-4rpcA:
undetectable		 4ky8A-4rpcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 115
SER A  97
SER A 224
ILE A 223
LEU A 191
 None
 0.88A 4ky8B-4rpcA:
undetectable		 4ky8B-4rpcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 115
SER A  97
SER A 224
ILE A 223
LEU A 191
 None
 1.04A 4ky8C-4rpcA:
undetectable		 4ky8C-4rpcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 115
SER A  97
SER A 224
ILE A 223
LEU A 191
 None
 0.88A 4ky8D-4rpcA:
undetectable		 4ky8D-4rpcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 115
SER A  97
SER A 224
ILE A 223
LEU A 191
 None
 0.89A 4ky8E-4rpcA:
undetectable		 4ky8E-4rpcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 ILE A  24
ALA A  71
THR A 127
SER A  97
LEU A  94
 None
 1.44A 4qztC-4rpcA:
undetectable		 4qztC-4rpcA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		4 / 6 ILE A  50
PRO A  51
ILE A 108
VAL A  83
 None
 0.98A 4zj8A-4rpcA:
3.3		 4zj8A-4rpcA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		3 / 3 ALA A 137
ASN A 140
LEU A 141
 None
 0.32A 5i1nB-4rpcA:
undetectable		 5i1nB-4rpcA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		3 / 3 ALA A 137
ASN A 140
LEU A 141
 None
 0.20A 5i1oC-4rpcA:
undetectable		 5i1oC-4rpcA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		3 / 3 ALA A 137
ASN A 140
LEU A 141
 None
 0.20A 5i1pA-4rpcA:
undetectable		 5i1pA-4rpcA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4rpc PUTATIVE ALPHA/BETA
HYDROLASE
(Desulfitobacteri
um
hafniense) 		5 / 12 VAL A  92
LEU A 147
HIS A 238
LEU A 166
LEU A 183
 None
 1.01A 6b0iB-4rpcA:
undetectable		 6b0iB-4rpcA:
15.45