SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rpd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		6 / 12 ALA A 484
ILE A 470
MET A 525
LEU A 249
PHE A 429
LEU A 448
 None
 1.38A 1dtlA-4rpdA:
undetectable		 1dtlA-4rpdA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 SER A 356
HIS A 299
ASP A 375
 None
 0.84A 2oxtA-4rpdA:
undetectable		 2oxtA-4rpdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		4 / 4 LEU A 447
ASP A 269
VAL A 453
THR A 276
 None
 1.20A 3cyxB-4rpdA:
undetectable		 3cyxB-4rpdA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 ASN A 441
ALA A 443
ARG A 430
 None
 0.81A 3tj7C-4rpdA:
undetectable
3tj7D-4rpdA:
undetectable		 3tj7C-4rpdA:
20.98
3tj7D-4rpdA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		5 / 12 ASN A 331
GLY A 334
PRO A 434
GLY A 442
ASN A 239
 None
 1.18A 3v3oB-4rpdA:
undetectable		 3v3oB-4rpdA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 ARG A 300
THR A 354
TRP A 355
 None
 1.26A 4d7hA-4rpdA:
undetectable		 4d7hA-4rpdA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		5 / 12 PHE A 359
LEU A 389
ILE A 332
ILE A 433
ALA A 330
 None
 1.16A 4enhA-4rpdA:
undetectable		 4enhA-4rpdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 ARG A 300
THR A 354
TRP A 355
 None
 1.22A 4uglA-4rpdA:
undetectable		 4uglA-4rpdA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 MET A 303
GLN A 304
ARG A 289
 None
 1.00A 5ewzB-4rpdA:
undetectable		 5ewzB-4rpdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 ARG A 300
THR A 354
TRP A 355
 None
 1.26A 5g6cA-4rpdA:
undetectable		 5g6cA-4rpdA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 MET A 303
GLN A 304
ARG A 289
 None
 1.02A 5m35B-4rpdA:
undetectable		 5m35B-4rpdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 MET A 303
GLN A 304
ARG A 289
 None
 1.05A 5m36A-4rpdA:
undetectable		 5m36A-4rpdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 MET A 303
GLN A 304
ARG A 289
 None
 1.03A 6fn9A-4rpdA:
undetectable		 6fn9A-4rpdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 MET A 303
GLN A 304
ARG A 289
 None
 1.04A 6fnaB-4rpdA:
undetectable		 6fnaB-4rpdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rpd CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 MET A 303
GLN A 304
ARG A 289
 None
 1.02A 6fnbA-4rpdA:
undetectable		 6fnbA-4rpdA:
18.58