SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rpf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 12 LEU A 153
ALA A  22
LEU A 300
HIS A 215
ILE A 211
 None
 1.15A 1s9pA-4rpfA:
undetectable		 1s9pA-4rpfA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 11 ARG A 246
ALA A 249
ALA A 245
LEU A 266
GLU A 232
 None
 1.13A 2bxeB-4rpfA:
undetectable		 2bxeB-4rpfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 12 LEU A  20
ILE A 161
ILE A  10
SER A   9
PHE A  17
 None
 1.18A 2ejtA-4rpfA:
undetectable		 2ejtA-4rpfA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 11 ILE A 211
GLY A 204
HIS A 203
LEU A  20
GLY A 209
 None
 1.40A 2fn1A-4rpfA:
undetectable		 2fn1A-4rpfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		3 / 3 PHE A 210
CYH A 214
PHE A 168
 None
 1.09A 3cr5X-4rpfA:
undetectable		 3cr5X-4rpfA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 12 ALA A 100
SER A  99
ILE A  64
LEU A 107
GLY A 106
 CIT  A 401 (-3.8A)
CIT  A 401 (-2.8A)
None
None
None
 1.11A 3k2hA-4rpfA:
undetectable		 3k2hA-4rpfA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 12 ALA A 100
SER A  99
ILE A  64
LEU A 107
GLY A 106
 CIT  A 401 (-3.8A)
CIT  A 401 (-2.8A)
None
None
None
 1.11A 3k2hB-4rpfA:
undetectable		 3k2hB-4rpfA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 12 GLY A 281
ALA A 248
ALA A 249
CYH A 257
ASP A 251
 None
 1.06A 3keeA-4rpfA:
undetectable		 3keeA-4rpfA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		3 / 3 ASP A  18
ASN A  12
SER A 137
 None
 0.80A 3lslA-4rpfA:
undetectable
3lslD-4rpfA:
undetectable		 3lslA-4rpfA:
20.29
3lslD-4rpfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		3 / 3 SER A 137
ASP A  18
ASN A  12
 None
 0.88A 3lslA-4rpfA:
undetectable
3lslD-4rpfA:
undetectable		 3lslA-4rpfA:
20.29
3lslD-4rpfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 12 ALA A 100
SER A  99
ILE A  64
LEU A 107
GLY A 106
 CIT  A 401 (-3.8A)
CIT  A 401 (-2.8A)
None
None
None
 1.08A 3nrrA-4rpfA:
undetectable		 3nrrA-4rpfA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 12 ALA A 100
SER A  99
ILE A  64
LEU A 107
GLY A 106
 CIT  A 401 (-3.8A)
CIT  A 401 (-2.8A)
None
None
None
 1.09A 3nrrB-4rpfA:
undetectable		 3nrrB-4rpfA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 12 ILE A 259
SER A 262
GLY A  95
SER A 183
THR A 184
 None
CIT  A 401 (-3.0A)
CIT  A 401 (-3.3A)
None
CIT  A 401 (-2.9A)
 1.39A 3r75A-4rpfA:
undetectable		 3r75A-4rpfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 12 ILE A 259
SER A 262
GLY A  95
SER A 183
THR A 184
 None
CIT  A 401 (-3.0A)
CIT  A 401 (-3.3A)
None
CIT  A 401 (-2.9A)
 1.40A 3r75B-4rpfA:
undetectable		 3r75B-4rpfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 11 GLY A  16
ALA A 256
VAL A  13
MET A 151
ILE A 211
 None
 1.06A 4j4vA-4rpfA:
undetectable		 4j4vA-4rpfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 11 GLY A  95
ARG A 188
ALA A 185
VAL A 182
ILE A 259
 CIT  A 401 (-3.3A)
None
None
None
None
 1.31A 4j4vA-4rpfA:
undetectable		 4j4vA-4rpfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 11 GLY A  16
ALA A 256
VAL A  13
MET A 151
ILE A 211
 None
 1.14A 4j4vD-4rpfA:
undetectable
4j4vE-4rpfA:
undetectable		 4j4vD-4rpfA:
21.43
4j4vE-4rpfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 11 PHE A  52
LEU A  96
ARG A  51
PRO A  26
VAL A  24
 None
 1.42A 4mk4B-4rpfA:
undetectable		 4mk4B-4rpfA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		4 / 6 TYR A 287
GLU A 232
THR A 236
LEU A 239
 None
 1.12A 4qztA-4rpfA:
undetectable		 4qztA-4rpfA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		4 / 5 PHE A  44
PRO A  81
ALA A  83
PHE A 113
 None
 1.29A 4z4cA-4rpfA:
undetectable		 4z4cA-4rpfA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		4 / 5 PHE A  44
PRO A  81
ALA A  83
PHE A 113
 None
 1.26A 4z4dA-4rpfA:
undetectable		 4z4dA-4rpfA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		4 / 5 PHE A  44
PRO A  81
ALA A  83
PHE A 113
 None
 1.24A 4z4eA-4rpfA:
undetectable		 4z4eA-4rpfA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 11 GLY A 304
ASP A 301
ALA A  23
TYR A 147
VAL A 104
 None
 1.44A 5c8tB-4rpfA:
undetectable		 5c8tB-4rpfA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		4 / 6 GLY A  11
SER A 260
GLY A  95
ASN A 142
 None
None
CIT  A 401 (-3.3A)
CIT  A 401 (-3.3A)
 0.80A 5k4pA-4rpfA:
undetectable		 5k4pA-4rpfA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		4 / 7 SER A  94
PRO A 178
TYR A 287
PHE A 294
 CIT  A 401 (-3.6A)
None
None
None
 1.24A 5l1fC-4rpfA:
undetectable		 5l1fC-4rpfA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		4 / 5 SER A  54
VAL A  53
LYS A  55
PRO A  91
 None
 1.46A 6fi4A-4rpfA:
undetectable
6fi4B-4rpfA:
undetectable		 6fi4A-4rpfA:
22.74
6fi4B-4rpfA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 9 GLY A 263
GLY A  95
TYR A 287
VAL A  24
GLU A 232
 None
CIT  A 401 (-3.3A)
None
None
None
 1.45A 6gnfA-4rpfA:
undetectable		 6gnfA-4rpfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		4 / 6 ILE A 190
ALA A 185
ARG A 188
ASP A  18
 None
 1.17A 6hu9m-4rpfA:
undetectable
6hu9q-4rpfA:
undetectable		 6hu9m-4rpfA:
21.58
6hu9q-4rpfA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4rpf HOMOSERINE KINASE
(Yersinia
pestis) 		5 / 12 LYS A   3
LEU A 308
THR A  30
ALA A 105
ASP A  34
 None
 1.31A 6ie8A-4rpfA:
undetectable		 6ie8A-4rpfA:
20.38