SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 6 HIS B  65
GLY B  63
TYR B  48
TYR B  62
GLU B  50
 FAD  B 401 (-3.5A)
FAD  B 401 (-3.5A)
None
None
None
 1.41A 1dmaB-4rphB:
undetectable		 1dmaB-4rphB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY B  14
GLU B  38
ARG B  39
ASP B 224
THR B 244
 FAD  B 401 (-3.3A)
FAD  B 401 (-2.6A)
None
FAD  B 401 (-3.5A)
FAD  B 401 (-4.6A)
 0.91A 1jg3B-4rphB:
undetectable		 1jg3B-4rphB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU B 108
GLN B 101
PHE B 157
LEU B 153
 None
 0.93A 1v54P-4rphB:
undetectable
1v54W-4rphB:
undetectable		 1v54P-4rphB:
19.55
1v54W-4rphB:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		3 / 3 GLY B  45
GLU B  38
ASN B  46
 FAD  B 401 (-3.0A)
FAD  B 401 (-2.6A)
FAD  B 401 ( 4.0A)
 0.61A 1zq9A-4rphB:
undetectable		 1zq9A-4rphB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE B  67
VAL B  78
TRP B 207
 None
 0.84A 2cc8A-4rphB:
undetectable		 2cc8A-4rphB:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE B  67
VAL B  78
TRP B 207
 None
 0.84A 2ccbA-4rphB:
undetectable		 2ccbA-4rphB:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU B 108
GLN B 101
PHE B 157
LEU B 153
 None
 0.93A 2eikC-4rphB:
undetectable
2eikJ-4rphB:
undetectable		 2eikC-4rphB:
19.55
2eikJ-4rphB:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 7 HIS B  65
HIS B 294
ARG B 292
TYR B 328
 FAD  B 401 (-3.5A)
None
GDU  B 402 (-2.7A)
GDU  B 402 ( 4.6A)
 1.32A 2vmyA-4rphB:
undetectable
2vmyB-4rphB:
undetectable		 2vmyA-4rphB:
21.91
2vmyB-4rphB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 8 TYR B 328
HIS B  65
HIS B 294
ARG B 292
 GDU  B 402 ( 4.6A)
FAD  B 401 (-3.5A)
None
GDU  B 402 (-2.7A)
 1.26A 2vmyA-4rphB:
undetectable
2vmyB-4rphB:
undetectable		 2vmyA-4rphB:
21.91
2vmyB-4rphB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE B  67
VAL B  78
TRP B 207
 None
 0.84A 2vx9A-4rphB:
undetectable		 2vx9A-4rphB:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU B 108
GLN B 101
PHE B 157
LEU B 153
 None
 0.93A 3ag2C-4rphB:
undetectable		 3ag2C-4rphB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU B 108
GLN B 101
PHE B 157
LEU B 153
 None
 0.97A 3ag2P-4rphB:
undetectable
3ag2W-4rphB:
undetectable		 3ag2P-4rphB:
19.55
3ag2W-4rphB:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU B 108
GLN B 101
PHE B 157
LEU B 153
 None
 0.93A 3ag4P-4rphB:
undetectable
3ag4W-4rphB:
undetectable		 3ag4P-4rphB:
19.55
3ag4W-4rphB:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU B 108
GLN B 101
PHE B 157
LEU B 153
 None
 0.90A 3asnC-4rphB:
undetectable
3asnJ-4rphB:
undetectable		 3asnC-4rphB:
19.55
3asnJ-4rphB:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY B  16
GLY B  14
ALA B  47
THR B 205
LEU B 208
 FAD  B 401 (-3.4A)
FAD  B 401 (-3.3A)
None
None
None
 0.99A 3p2kB-4rphB:
undetectable		 3p2kB-4rphB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR B 185
THR B 186
PHE B 187
LEU B 108
 None
 1.31A 3qelC-4rphB:
2.5		 3qelC-4rphB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 7 ASN B 140
ALA B 175
THR B 179
LEU B 148
 None
 0.97A 3t3sC-4rphB:
undetectable		 3t3sC-4rphB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA B  93
PHE B 102
ASN B 284
ALA B 156
 None
GDU  B 402 (-3.9A)
GDU  B 402 (-3.6A)
None
 0.90A 3t3sD-4rphB:
undetectable		 3t3sD-4rphB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 10 HIS B 300
MET B 369
PHE B  17
GLY B  16
GLY B 203
 None
FAD  B 401 (-4.4A)
None
FAD  B 401 (-3.4A)
None
 1.31A 3v3oD-4rphB:
11.7		 3v3oD-4rphB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY B  63
TYR B  48
TYR B  62
GLU B  50
 FAD  B 401 (-3.5A)
None
None
None
 1.33A 4ae1B-4rphB:
undetectable		 4ae1B-4rphB:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 8 TRP B 225
ARG B 229
VAL B 241
VAL B 355
 None
 0.87A 4em2A-4rphB:
undetectable		 4em2A-4rphB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 6 GLN B 276
ILE B 312
PHE B 296
PHE B 299
 None
 1.13A 4fgkA-4rphB:
undetectable		 4fgkA-4rphB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 6 ASN B 210
MET B 369
ILE B 217
VAL B 219
 None
FAD  B 401 (-4.4A)
None
None
 0.78A 4olmA-4rphB:
undetectable		 4olmA-4rphB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 6 TYR B  62
HIS B  42
GLY B  44
GLU B  38
 None
None
None
FAD  B 401 (-2.6A)
 1.25A 4zbqA-4rphB:
undetectable		 4zbqA-4rphB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY B 362
TYR B 250
THR B 244
GLY B  14
PHE B 226
 None
None
FAD  B 401 (-4.6A)
FAD  B 401 (-3.3A)
FAD  B 401 (-4.4A)
 1.06A 5d4uB-4rphB:
undetectable		 5d4uB-4rphB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.91A 5n0oA-4rphB:
undetectable		 5n0oA-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.91A 5n0oB-4rphB:
undetectable		 5n0oB-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.88A 5n0rA-4rphB:
undetectable		 5n0rA-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.90A 5n0sA-4rphB:
undetectable		 5n0sA-4rphB:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.90A 5n0tA-4rphB:
undetectable		 5n0tA-4rphB:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.89A 5n0tB-4rphB:
undetectable		 5n0tB-4rphB:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.91A 5n0wA-4rphB:
undetectable		 5n0wA-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.92A 5n0xA-4rphB:
undetectable		 5n0xA-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE B 126
GLY B 150
PHE B 157
VAL B 158
ALA B 122
 None
None
None
GDU  B 402 (-3.2A)
None
 0.92A 5n0xB-4rphB:
undetectable		 5n0xB-4rphB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY B  14
GLY B 245
PRO B 246
GLY B 362
 FAD  B 401 (-3.3A)
FAD  B 401 (-3.4A)
None
None
 0.66A 6ag0C-4rphB:
undetectable		 6ag0C-4rphB:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR B 161
GLU B 315
TYR B  87
HIS B 294
 GDU  B 402 (-3.7A)
FAD  B 401 ( 4.1A)
None
None
 1.24A 6ep4A-4rphB:
undetectable		 6ep4A-4rphB:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 4rph UDP-GALACTOPYRANOSE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR B 328
GLU B 315
TYR B  87
HIS B 294
 GDU  B 402 ( 4.6A)
FAD  B 401 ( 4.1A)
None
None
 1.35A 6ep4A-4rphB:
undetectable		 6ep4A-4rphB:
11.17