SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4rqb HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Staphylococcus
aureus) 		5 / 12 ILE A 130
ILE A 175
ILE A  24
LEU A  28
CYH A  25
 None
 1.14A 2qo5A-4rqbA:
undetectable		 2qo5A-4rqbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4rqb HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Staphylococcus
aureus) 		5 / 12 LEU A 113
GLY A 110
ARG A 140
ILE A 130
ASP A 135
 UNL  A 202 ( 4.1A)
UNL  A 202 ( 3.1A)
None
None
None
 1.06A 3gwwA-4rqbA:
undetectable		 3gwwA-4rqbA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4rqb HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Staphylococcus
aureus) 		3 / 3 TYR A 148
ASP A  99
ASP A  35
 None
 0.79A 3r24A-4rqbA:
2.7		 3r24A-4rqbA:
21.24