SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 12 GLY A  52
GLY A 449
GLY A 450
LEU A 116
LEU A 121
 None
 0.83A 1eizA-4rqoA:
undetectable		 1eizA-4rqoA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 12 GLY A  52
GLY A 449
GLY A 450
LEU A 116
LEU A 121
 None
 0.81A 1ej0A-4rqoA:
undetectable		 1ej0A-4rqoA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 11 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.16A 1gtnM-4rqoA:
undetectable
1gtnN-4rqoA:
undetectable		 1gtnM-4rqoA:
10.45
1gtnN-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.14A 1gtnU-4rqoA:
undetectable
1gtnV-4rqoA:
undetectable		 1gtnU-4rqoA:
10.45
1gtnV-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 11 VAL A 361
TYR A 317
LEU A 301
ILE A 316
ASP A 315
 None
 1.43A 1t6zB-4rqoA:
undetectable		 1t6zB-4rqoA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.12A 1utdT-4rqoA:
0.3
1utdU-4rqoA:
undetectable		 1utdT-4rqoA:
10.45
1utdU-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 12 ALA A 350
SER A 351
ALA A 407
ALA A 288
GLY A 327
 None
 1.14A 2igtA-4rqoA:
undetectable		 2igtA-4rqoA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 12 ALA A 350
SER A 351
ALA A 407
ALA A 288
GLY A 327
 None
 1.12A 2igtB-4rqoA:
undetectable		 2igtB-4rqoA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 12 TYR A 330
VAL A 428
LEU A 180
ALA A 356
SER A 352
 None
 1.44A 3apvA-4rqoA:
undetectable		 3apvA-4rqoA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		4 / 4 ILE A 214
PHE A   6
ILE A 211
THR A 287
 None
 1.05A 3ia4A-4rqoA:
undetectable		 3ia4A-4rqoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 12 VAL A  46
ILE A  67
ALA A  27
LEU A  31
LEU A  34
 None
 0.76A 3n8yB-4rqoA:
undetectable		 3n8yB-4rqoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 11 TYR A 146
THR A 154
ILE A 336
THR A  57
GLU A 457
 None
 1.48A 3qelA-4rqoA:
2.6
3qelB-4rqoA:
undetectable		 3qelA-4rqoA:
22.75
3qelB-4rqoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		3 / 3 LEU A 236
ARG A 399
ASN A 279
 None
SF4  A 500 ( 4.6A)
None
 0.65A 3qxvD-4rqoA:
undetectable		 3qxvD-4rqoA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		4 / 5 ASN A  28
ALA A  75
PRO A  76
ALA A  66
 None
 1.23A 3twpD-4rqoA:
undetectable		 3twpD-4rqoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		4 / 8 ALA A 132
THR A  43
LEU A  99
LEU A  71
 None
 0.86A 4ejgB-4rqoA:
undetectable		 4ejgB-4rqoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 11 LEU A 425
LEU A 329
CYH A 183
LEU A 179
ALA A 176
 None
 1.16A 4p65B-4rqoA:
undetectable
4p65D-4rqoA:
undetectable
4p65G-4rqoA:
undetectable
4p65H-4rqoA:
undetectable		 4p65B-4rqoA:
5.06
4p65D-4rqoA:
5.06
4p65G-4rqoA:
5.00
4p65H-4rqoA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		4 / 6 HIS A 228
GLY A 283
GLU A 278
ASN A 224
 None
 1.13A 4zbqA-4rqoA:
undetectable		 4zbqA-4rqoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.15A 5eeuO-4rqoA:
undetectable
5eeuP-4rqoA:
undetectable		 5eeuO-4rqoA:
10.45
5eeuP-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.17A 5eeuQ-4rqoA:
0.3
5eeuR-4rqoA:
undetectable		 5eeuQ-4rqoA:
10.45
5eeuR-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		4 / 8 GLY A 348
HIS A 380
ALA A 354
HIS A 379
 None
 0.90A 5eevL-4rqoA:
undetectable
5eevV-4rqoA:
undetectable		 5eevL-4rqoA:
10.45
5eevV-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.16A 5eevO-4rqoA:
undetectable
5eevP-4rqoA:
0.3		 5eevO-4rqoA:
10.45
5eevP-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.17A 5eevQ-4rqoA:
undetectable
5eevR-4rqoA:
undetectable		 5eevQ-4rqoA:
10.45
5eevR-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		4 / 8 GLY A 348
HIS A 380
ALA A 354
HIS A 379
 None
 0.90A 5eewL-4rqoA:
undetectable
5eewV-4rqoA:
undetectable		 5eewL-4rqoA:
10.45
5eewV-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.16A 5eewO-4rqoA:
undetectable
5eewP-4rqoA:
undetectable		 5eewO-4rqoA:
10.45
5eewP-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.17A 5eewQ-4rqoA:
undetectable
5eewR-4rqoA:
undetectable		 5eewQ-4rqoA:
10.45
5eewR-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.16A 5eexO-4rqoA:
undetectable
5eexP-4rqoA:
0.3		 5eexO-4rqoA:
10.45
5eexP-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.16A 5eeyO-4rqoA:
undetectable
5eeyP-4rqoA:
undetectable		 5eeyO-4rqoA:
10.45
5eeyP-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.16A 5eezO-4rqoA:
undetectable
5eezP-4rqoA:
undetectable		 5eezO-4rqoA:
10.45
5eezP-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.16A 5ef0O-4rqoA:
undetectable
5ef0P-4rqoA:
0.3		 5ef0O-4rqoA:
10.45
5ef0P-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.16A 5ef1O-4rqoA:
undetectable
5ef1P-4rqoA:
0.3		 5ef1O-4rqoA:
10.45
5ef1P-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.16A 5ef2O-4rqoA:
undetectable
5ef2P-4rqoA:
undetectable		 5ef2O-4rqoA:
10.45
5ef2P-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		4 / 8 GLY A 348
HIS A 380
ALA A 354
HIS A 379
 None
 0.90A 5ef3L-4rqoA:
undetectable
5ef3V-4rqoA:
undetectable		 5ef3L-4rqoA:
10.45
5ef3V-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 10 GLY A 403
ALA A 354
HIS A 379
ILE A 296
ALA A 355
 None
 1.16A 5ef3O-4rqoA:
undetectable
5ef3P-4rqoA:
undetectable		 5ef3O-4rqoA:
10.45
5ef3P-4rqoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		3 / 3 TRP A 201
GLU A 198
ASP A   7
 None
 0.99A 5gqbA-4rqoA:
undetectable		 5gqbA-4rqoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 12 VAL A 408
GLY A 357
GLU A 370
ALA A 191
ALA A 360
 None
 0.95A 5n5dA-4rqoA:
undetectable		 5n5dA-4rqoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 12 ALA A  27
GLU A  35
LEU A  33
ILE A 141
VAL A  46
 None
 1.27A 5vlmG-4rqoA:
1.7		 5vlmG-4rqoA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		4 / 5 HIS A 380
ALA A 350
SER A 351
GLY A 403
 None
 1.25A 5yodB-4rqoA:
undetectable		 5yodB-4rqoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		4 / 5 HIS A 380
ALA A 350
SER A 351
GLY A 403
 None
 1.27A 5yodD-4rqoA:
undetectable		 5yodD-4rqoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 9 ALA A 288
PHE A 152
GLY A 149
SER A  16
GLY A 292
 None
None
None
None
SF4  A 500 ( 4.2A)
 1.34A 6awoA-4rqoA:
undetectable		 6awoA-4rqoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4rqo L-SERINE DEHYDRATASE
(Legionella
pneumophila) 		5 / 9 ALA A 288
PHE A 152
GLY A 149
SER A  16
GLY A 292
 None
None
None
None
SF4  A 500 ( 4.2A)
 1.34A 6awqA-4rqoA:
undetectable		 6awqA-4rqoA:
21.11