SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rqq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLN H   6
SER H   7
TYR H  90
GLN L  38
 None
 1.48A 1eiiA-4rqqH:
undetectable		 1eiiA-4rqqH:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU L 135
ALA H 142
SER H 137
THR H 140
 None
 1.08A 1ictB-4rqqL:
undetectable		 1ictB-4rqqL:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
LIGHT CHAIN
(Homo
sapiens) 		5 / 11 ARG L  42
VAL L  58
GLY L  57
ALA L  55
LEU L  47
 None
 1.21A 2bxgA-4rqqL:
undetectable		 2bxgA-4rqqL:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU H 194
GLY H 195
ALA H 130
PRO H 131
 None
 0.48A 3huoA-4rqqH:
undetectable		 3huoA-4rqqH:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
LIGHT CHAIN
(Homo
sapiens) 		3 / 3 LYS L  39
ARG L  61
LEU L  47
 None
 1.40A 3v4tE-4rqqL:
undetectable		 3v4tE-4rqqL:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 193
GLY H 139
THR H 140
ALA H 141
THR H 136
 None
 1.04A 4qvyH-4rqqH:
undetectable		 4qvyH-4rqqH:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 193
GLY H 139
THR H 140
ALA H 141
THR H 136
 None
 1.04A 4qvyV-4rqqH:
undetectable
4qvyW-4rqqH:
undetectable		 4qvyV-4rqqH:
20.61
4qvyW-4rqqH:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 193
GLY H 139
THR H 140
ALA H 141
THR H 136
 None
 1.02A 5d0xV-4rqqH:
undetectable		 5d0xV-4rqqH:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 193
GLY H 139
THR H 140
ALA H 141
THR H 136
 None
 0.98A 5l5fH-4rqqH:
undetectable
5l5fI-4rqqH:
undetectable		 5l5fH-4rqqH:
20.61
5l5fI-4rqqH:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 193
GLY H 139
THR H 140
ALA H 141
THR H 136
 None
 0.98A 5l5fV-4rqqH:
undetectable
5l5fW-4rqqH:
undetectable		 5l5fV-4rqqH:
20.61
5l5fW-4rqqH:
20.15