SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rqu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 7 GLY A 264
ALA A 199
THR A 261
ILE A 257
 None
 0.84A 1gtnA-4rquA:
undetectable
1gtnK-4rquA:
undetectable		 1gtnA-4rquA:
11.52
1gtnK-4rquA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 9 LEU A  46
ASP A  50
THR A 148
ILE A  41
ILE A 374
 None
 1.50A 1hzeA-4rquA:
undetectable
1hzeB-4rquA:
undetectable		 1hzeA-4rquA:
14.89
1hzeB-4rquA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 9 ILE A 374
LEU A  46
ASP A  50
THR A 148
ILE A  41
 None
 1.49A 1hzeA-4rquA:
undetectable
1hzeB-4rquA:
undetectable		 1hzeA-4rquA:
14.89
1hzeB-4rquA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 209
GLY A 213
LEU A 187
GLY A 178
VAL A 269
 None
None
None
ZN  A 401 ( 4.8A)
None
 1.01A 1jg2A-4rquA:
6.5		 1jg2A-4rquA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		3 / 3 ALA A  12
VAL A  23
TRP A  16
 None
 0.92A 1jnoA-4rquA:
undetectable		 1jnoA-4rquA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		3 / 3 ALA A  12
VAL A  23
TRP A  16
 None
 0.91A 1jnoB-4rquA:
undetectable		 1jnoB-4rquA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 4 SER A 180
LEU A 187
TYR A 325
GLY A 209
 None
 1.42A 1liiA-4rquA:
3.5		 1liiA-4rquA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 7 GLY A  73
MET A 377
ILE A  39
PRO A  93
 None
 1.08A 1rxcL-4rquA:
undetectable		 1rxcL-4rquA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 213
GLY A 182
GLY A 209
ALA A 211
PHE A 321
 None
 1.15A 2dpmA-4rquA:
3.8		 2dpmA-4rquA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 11 SER A 131
SER A 147
ALA A  13
VAL A  27
ILE A 135
 None
 1.03A 2nnhA-4rquA:
undetectable		 2nnhA-4rquA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		3 / 3 TYR A 338
GLU A 237
ASP A 233
 None
 0.86A 3bxoA-4rquA:
6.8		 3bxoA-4rquA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 5 GLY A  97
GLU A  98
GLY A 158
PRO A 327
 None
 1.05A 3onnA-4rquA:
5.1		 3onnA-4rquA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 4 LEU A 179
ILE A 371
GLY A 209
PHE A 238
 None
 1.08A 4dc3A-4rquA:
3.8		 4dc3A-4rquA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 7 GLY A  73
MET A 377
ILE A  39
PRO A  93
 None
 1.03A 4e1vB-4rquA:
undetectable		 4e1vB-4rquA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 209
ALA A 211
VAL A 240
LEU A 203
ILE A 371
 None
 1.24A 4pd9A-4rquA:
undetectable		 4pd9A-4rquA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 6 GLY A 323
THR A 181
SER A 180
GLY A 178
 None
None
None
ZN  A 401 ( 4.8A)
 0.90A 5k4pA-4rquA:
undetectable		 5k4pA-4rquA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		5 / 12 PHE A 321
VAL A 295
GLU A  70
THR A 146
GLY A  68
 None
None
ZN  A 401 ( 4.5A)
None
None
 1.36A 5xiqD-4rquA:
undetectable		 5xiqD-4rquA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 203
LEU A 208
ALA A 210
ALA A 211
 None
 0.84A 6a7jA-4rquA:
undetectable		 6a7jA-4rquA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 8 HIS A  35
GLY A  97
LEU A 116
GLU A 101
 None
 0.70A 6mdqA-4rquA:
undetectable		 6mdqA-4rquA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4rqu ALCOHOL
DEHYDROGENASE
(Arabidopsis
thaliana) 		4 / 7 GLY A 158
HIS A 127
GLU A  80
GLY A  81
 None
 0.86A 6n7fA-4rquA:
4.2		 6n7fA-4rquA:
13.51