SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 169
ALA A 168
ALA A 164
THR A 162
VAL A 146
 None
 1.00A 1cbsA-4rr5A:
undetectable		 1cbsA-4rr5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A  73
LEU A  70
ILE A  69
ILE A  66
LEU A 290
 None
 0.99A 1xdkF-4rr5A:
undetectable		 1xdkF-4rr5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 SER A 217
VAL A 100
LEU A  95
 None
 0.61A 1yajG-4rr5A:
undetectable		 1yajG-4rr5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 GLY A 161
GLU A 145
ILE A 159
ALA A 126
VAL A 158
 None
 1.36A 2drdA-4rr5A:
2.0		 2drdA-4rr5A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 169
ALA A 168
ALA A 164
THR A 162
VAL A 146
 None
 1.02A 2fr3A-4rr5A:
undetectable		 2fr3A-4rr5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A 113
GLY A 240
GLY A   9
MET A 125
 ACT  A 301 (-3.3A)
None
None
None
 0.91A 2y6rB-4rr5A:
undetectable		 2y6rB-4rr5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		4 / 4 VAL A 146
PHE A 191
PHE A 187
VAL A 183
 None
None
ACT  A 301 ( 4.6A)
None
 1.41A 3rv5C-4rr5A:
undetectable
3rv5D-4rr5A:
undetectable		 3rv5C-4rr5A:
14.73
3rv5D-4rr5A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 GLY A 161
GLU A 145
ASN A 143
ILE A 159
ALA A 126
 None
 1.36A 5entC-4rr5A:
4.1		 5entC-4rr5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A  97
GLN A  10
PHE A   7
THR A  59
GLU A  91
 None
ACT  A 301 ( 4.7A)
None
None
None
 1.04A 5hfjC-4rr5A:
undetectable		 5hfjC-4rr5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A  97
GLN A  10
PHE A   7
THR A  59
GLU A  91
 None
ACT  A 301 ( 4.7A)
None
None
None
 1.08A 5hfjG-4rr5A:
undetectable		 5hfjG-4rr5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 243
PRO A 221
ASN A 250
 None
 0.97A 5jwaA-4rr5A:
undetectable
5jwaH-4rr5A:
undetectable		 5jwaA-4rr5A:
18.16
5jwaH-4rr5A:
18.16