SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rrj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.99A 1fbyA-4rrjA:
undetectable		 1fbyA-4rrjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.98A 1fbyB-4rrjA:
undetectable		 1fbyB-4rrjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.91A 1fm6A-4rrjA:
undetectable		 1fm6A-4rrjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.97A 1fm9A-4rrjA:
undetectable		 1fm9A-4rrjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.91A 1k74A-4rrjA:
undetectable		 1k74A-4rrjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.98A 1xdkE-4rrjA:
undetectable		 1xdkE-4rrjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.92A 1xiuA-4rrjA:
undetectable		 1xiuA-4rrjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.94A 1xlsA-4rrjA:
undetectable		 1xlsA-4rrjA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.94A 1xlsB-4rrjA:
undetectable		 1xlsB-4rrjA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.94A 1xlsC-4rrjA:
undetectable		 1xlsC-4rrjA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.94A 1xlsD-4rrjA:
undetectable		 1xlsD-4rrjA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.94A 2aclG-4rrjA:
undetectable		 2aclG-4rrjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 10 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.92A 3falC-4rrjA:
undetectable		 3falC-4rrjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 11 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.97A 3fc6A-4rrjA:
undetectable		 3fc6A-4rrjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.95A 3oapA-4rrjA:
undetectable		 3oapA-4rrjA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		4 / 6 ILE A  58
ARG A   2
MET A   1
THR A  41
 None
None
None
A3S  A 500 ( 4.5A)
 1.18A 3wg7A-4rrjA:
undetectable
3wg7J-4rrjA:
undetectable		 3wg7A-4rrjA:
15.58
3wg7J-4rrjA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		3 / 3 LEU A   4
ARG A 132
ARG A   2
 None
 0.97A 4yiaB-4rrjA:
undetectable		 4yiaB-4rrjA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.89A 5uanA-4rrjA:
undetectable		 5uanA-4rrjA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.92A 5z12B-4rrjA:
undetectable		 5z12B-4rrjA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.91A 5z12C-4rrjA:
undetectable		 5z12C-4rrjA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.95A 6a5yD-4rrjA:
undetectable		 6a5yD-4rrjA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rrj PROBABLE
THREONINE--TRNA
LIGASE 2
(Aeropyrum
pernix) 		5 / 12 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.93A 6a5zL-4rrjA:
undetectable		 6a5zL-4rrjA:
24.46