SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rs1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 VAL B 205
VAL B 207
TRP B 218
 None
 0.95A 1av2A-4rs1B:
undetectable
1av2B-4rs1B:
undetectable		 1av2A-4rs1B:
2.56
1av2B-4rs1B:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_1
(SERINE/THREONINE
PHOSPHATASE B2
FK506-BINDING
PROTEIN)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 4 TRP B 287
SER B 288
PHE B 199
GLU B 197
 None
 1.35A 1tcoA-4rs1B:
0.0		 1tcoA-4rs1B:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 VAL B 205
VAL B 207
TRP B 218
 None
 0.98A 1w5uA-4rs1B:
undetectable
1w5uB-4rs1B:
undetectable		 1w5uA-4rs1B:
2.56
1w5uB-4rs1B:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 VAL B 207
TRP B 218
VAL B 205
 None
 0.98A 2izqC-4rs1B:
undetectable
2izqD-4rs1B:
undetectable		 2izqC-4rs1B:
2.56
2izqD-4rs1B:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 7 LYS B  89
THR B  74
GLU B  76
THR B  44
VAL B  50
 None
 0.87A 3em0B-4rs1B:
undetectable		 3em0B-4rs1B:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 GLY B 158
ILE B 135
PHE B 105
PHE B 187
 None
 0.67A 3ko0B-4rs1B:
undetectable
3ko0J-4rs1B:
undetectable		 3ko0B-4rs1B:
18.62
3ko0J-4rs1B:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 GLY B 158
ILE B 135
PHE B 105
PHE B 187
 None
 0.79A 3ko0K-4rs1B:
undetectable
3ko0S-4rs1B:
undetectable		 3ko0K-4rs1B:
18.62
3ko0S-4rs1B:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR
(Homo
sapiens) 		5 / 12 HIS A  15
LEU A  77
TYR A  84
LEU A  55
ILE A  19
 None
 1.09A 3n8xB-4rs1A:
undetectable		 3n8xB-4rs1A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 PHE B 186
TYR B  92
LEU B  69
PHE B  21
 None
 1.01A 3rqwC-4rs1B:
2.7
3rqwD-4rs1B:
2.8		 3rqwC-4rs1B:
18.82
3rqwD-4rs1B:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR
(Homo
sapiens) 		4 / 8 PHE A  47
ILE A  19
TYR A  84
LEU A  55
 None
 0.97A 3rqwI-4rs1A:
undetectable
3rqwJ-4rs1A:
undetectable		 3rqwI-4rs1A:
15.61
3rqwJ-4rs1A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 PHE B 186
TYR B  92
LEU B  69
PHE B  21
 None
 1.00A 3rqwI-4rs1B:
1.9
3rqwJ-4rs1B:
undetectable		 3rqwI-4rs1B:
18.82
3rqwJ-4rs1B:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 TYR B  92
LEU B  69
PHE B  21
PHE B 186
 None
 1.01A 3rqwF-4rs1B:
2.1
3rqwJ-4rs1B:
undetectable		 3rqwF-4rs1B:
18.82
3rqwJ-4rs1B:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 ARG B 208
LEU B 215
ARG B 261
GLU B 259
 None
 1.47A 3zmdA-4rs1B:
undetectable
3zmdB-4rs1B:
undetectable		 3zmdA-4rs1B:
19.71
3zmdB-4rs1B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 GLN B 103
THR B 100
THR B 124
 None
 0.68A 4fu9A-4rs1B:
undetectable		 4fu9A-4rs1B:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 GLN B 103
THR B 100
THR B 124
 None
 0.69A 4fufA-4rs1B:
undetectable		 4fufA-4rs1B:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR
GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 7 ASN B 137
GLU A  51
GLU A  45
ARG B  65
 None
 0.80A 4mi4B-4rs1B:
undetectable
4mi4C-4rs1B:
undetectable		 4mi4B-4rs1B:
19.37
4mi4C-4rs1B:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR
GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 ASN B 137
GLU A  51
GLU A  45
ARG B  65
 None
 0.79A 4mj8B-4rs1B:
undetectable
4mj8C-4rs1B:
undetectable		 4mj8B-4rs1B:
19.15
4mj8C-4rs1B:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 TRP B 287
SER B 288
PHE B 199
GLU B 197
 None
 1.27A 5b8iA-4rs1B:
undetectable		 5b8iA-4rs1B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 ILE B 144
GLY B 166
ARG B 142
ARG B 170
LEU B 191
 None
 1.13A 5h5fA-4rs1B:
undetectable		 5h5fA-4rs1B:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 ASP B 162
ARG B 140
ASN B 137
ASN B 163
 None
 1.06A 5l6eA-4rs1B:
undetectable		 5l6eA-4rs1B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 8 ARG B 283
ASP B 257
GLY B 256
PHE B 232
 None
GOL  B 303 (-4.0A)
None
None
 0.74A 5x5qF-4rs1B:
undetectable		 5x5qF-4rs1B:
22.70