SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rs2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		5 / 12 LEU A 100
LEU A  77
PHE A 120
VAL A  57
ALA A  58
 None
COA  A 200 ( 4.4A)
None
None
None
 1.06A 1tlsA-4rs2A:
undetectable		 1tlsA-4rs2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		5 / 12 LEU A 100
LEU A  77
PHE A 120
VAL A  57
ALA A  58
 None
COA  A 200 ( 4.4A)
None
None
None
 1.13A 1tsnA-4rs2A:
undetectable		 1tsnA-4rs2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		5 / 10 ALA A  58
VAL A  31
ILE A  14
GLY A  55
VAL A  79
 None
None
None
None
COA  A 200 (-4.4A)
 1.09A 3oxvB-4rs2A:
undetectable		 3oxvB-4rs2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		5 / 11 ALA A  58
VAL A  31
ILE A  14
GLY A  55
VAL A  79
 None
None
None
None
COA  A 200 (-4.4A)
 1.04A 3oxvD-4rs2A:
undetectable		 3oxvD-4rs2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		4 / 6 ARG A  35
TYR A  56
PRO A  76
LEU A  34
 None
 1.33A 3tgvB-4rs2A:
undetectable		 3tgvB-4rs2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		4 / 5 ARG A  35
TYR A  56
PRO A  76
LEU A  34
 None
 1.39A 3tgvC-4rs2A:
undetectable		 3tgvC-4rs2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		4 / 6 ARG A  35
TYR A  56
PRO A  76
LEU A  34
 None
 1.40A 3tgvD-4rs2A:
undetectable		 3tgvD-4rs2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		4 / 7 ILE A  14
GLU A   6
HIS A 163
VAL A  62
 None
 0.99A 4a97A-4rs2A:
undetectable		 4a97A-4rs2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		4 / 7 ILE A  14
GLU A   6
HIS A 163
VAL A  62
 None
 0.91A 4a97D-4rs2A:
undetectable		 4a97D-4rs2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		4 / 7 ILE A  14
GLU A   6
HIS A 163
VAL A  62
 None
 0.96A 4a97H-4rs2A:
undetectable		 4a97H-4rs2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		5 / 12 GLY A  55
TYR A  83
LEU A  18
GLY A  13
ILE A  14
 None
 1.01A 5d4uD-4rs2A:
undetectable		 5d4uD-4rs2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		4 / 7 THR A  41
LEU A  42
VAL A  45
TYR A  56
 None
 0.77A 5ov9A-4rs2A:
undetectable		 5ov9A-4rs2A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		4 / 8 THR A  41
LEU A  42
VAL A  45
TYR A  56
 None
 0.74A 5ov9B-4rs2A:
undetectable		 5ov9B-4rs2A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4rs2 PREDICTED
ACYLTRANSFERASE WITH
ACYL-COA
N-ACYLTRANSFERASE
DOMAIN
(Escherichia
coli) 		3 / 3 ASP A  15
ARG A  19
ASP A  33
 None
 0.87A 5zvgA-4rs2A:
undetectable		 5zvgA-4rs2A:
20.73