SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rs3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 144
GLY A 250
ASP A 137
SER A 168
ILE A 171
 None
None
XYL  A 401 ( 4.8A)
None
None
 1.19A 1q8jB-4rs3A:
2.0		 1q8jB-4rs3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 250
ASP A 137
SER A 168
ILE A 171
GLY A 163
 None
XYL  A 401 ( 4.8A)
None
None
None
 1.11A 1q8jB-4rs3A:
2.0		 1q8jB-4rs3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASP A 249
GLY A 163
ALA A 140
ILE A 248
 XYL  A 401 (-2.7A)
None
None
None
 0.85A 2aofA-4rs3A:
undetectable		 2aofA-4rs3A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 141
GLY A 163
GLY A 169
GLY A 174
ASN A  73
 None
None
XYL  A 401 ( 3.8A)
ACT  A 433 (-3.5A)
None
 0.94A 3eluA-4rs3A:
undetectable		 3eluA-4rs3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 141
GLY A 163
GLY A 169
GLY A 174
ASN A  73
 None
None
XYL  A 401 ( 3.8A)
ACT  A 433 (-3.5A)
None
 0.88A 3elwA-4rs3A:
undetectable		 3elwA-4rs3A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  37
ILE A  94
VAL A 120
LEU A 333
PRO A 295
 None
 1.18A 3em0B-4rs3A:
undetectable		 3em0B-4rs3A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 141
GLY A 163
GLY A 169
GLY A 174
ASN A  73
 None
None
XYL  A 401 ( 3.8A)
ACT  A 433 (-3.5A)
None
 0.90A 3embA-4rs3A:
undetectable		 3embA-4rs3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLN A 269
MET A 299
SER A  45
SER A  46
 XYL  A 401 (-3.1A)
None
XYL  A 401 ( 4.8A)
CL  A 418 ( 4.3A)
 1.06A 3pmzD-4rs3A:
undetectable		 3pmzD-4rs3A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A 141
ILE A 177
GLN A 223
VAL A 246
 None
ACT  A 433 ( 3.8A)
None
None
 1.02A 4d39B-4rs3A:
undetectable		 4d39B-4rs3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 245
GLY A 265
PHE A 263
MET A 148
ALA A 149
 None
 1.26A 4eb4B-4rs3A:
undetectable		 4eb4B-4rs3A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 167
GLY A 166
ASN A 121
VAL A  96
GLN A  78
 None
None
XYL  A 401 (-3.0A)
None
None
 1.18A 4fgkA-4rs3A:
4.7
4fgkB-4rs3A:
3.7		 4fgkA-4rs3A:
23.96
4fgkB-4rs3A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ILE A 187
LEU A 152
LYS A 155
ASN A 157
 None
None
CL  A 425 (-3.5A)
CL  A 425 (-3.7A)
 0.95A 4g19A-4rs3A:
undetectable		 4g19A-4rs3A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A 141
ILE A 177
GLN A 223
VAL A 246
 None
ACT  A 433 ( 3.8A)
None
None
 0.99A 4kcnA-4rs3A:
undetectable		 4kcnA-4rs3A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 232
LEU A 229
GLY A 230
LEU A 161
VAL A 246
 None
 1.22A 4olmA-4rs3A:
undetectable		 4olmA-4rs3A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ILE A  86
LEU A  85
ILE A 115
LEU A 117
 None
 0.78A 4zvcA-4rs3A:
undetectable
4zvcB-4rs3A:
undetectable		 4zvcA-4rs3A:
14.83
4zvcB-4rs3A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ILE A 115
LEU A 117
ILE A  86
LEU A  85
 None
 0.78A 4zvcA-4rs3A:
undetectable
4zvcB-4rs3A:
undetectable		 4zvcA-4rs3A:
14.83
4zvcB-4rs3A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A  93
ILE A  86
ASP A  83
VAL A  41
LEU A 103
 None
 1.30A 5jkwA-4rs3A:
undetectable		 5jkwA-4rs3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A  93
ILE A  86
ASP A  83
VAL A  96
LEU A 103
 None
 1.43A 5jkwA-4rs3A:
undetectable		 5jkwA-4rs3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 322
GLY A  54
VAL A 273
SER A 276
 None
 0.92A 5m8rC-4rs3A:
undetectable		 5m8rC-4rs3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A  94
ALA A 282
LEU A 279
ILE A  64
 None
 0.85A 5mvmB-4rs3A:
undetectable
5mvmC-4rs3A:
undetectable		 5mvmB-4rs3A:
12.99
5mvmC-4rs3A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A  51
GLN A  78
TRP A  68
ASP A 249
 None
None
None
XYL  A 401 (-2.7A)
 1.09A 5vlmE-4rs3A:
undetectable		 5vlmE-4rs3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A  51
GLN A  78
TRP A  68
ASP A 249
 None
None
None
XYL  A 401 (-2.7A)
 1.01A 5vlmH-4rs3A:
undetectable		 5vlmH-4rs3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLN A  78
ASN A  69
VAL A  95
LEU A 118
 None
 1.25A 5xdhA-4rs3A:
undetectable
5xdhC-4rs3A:
undetectable		 5xdhA-4rs3A:
15.46
5xdhC-4rs3A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 326
ALA A  61
GLN A 330
 None
 0.69A 6gb9A-4rs3A:
3.3		 6gb9A-4rs3A:
21.34