SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rsh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		5 / 11 PHE A 170
ILE A 167
ASN A 197
ASP A 187
LEU A 156
 None
 1.31A 1ju6A-4rshA:
undetectable		 1ju6A-4rshA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		5 / 11 PHE A 170
ILE A 167
ASN A 197
ASP A 187
LEU A 156
 None
 1.31A 1ju6D-4rshA:
undetectable		 1ju6D-4rshA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		5 / 12 THR A  64
GLY A 123
GLY A 121
VAL A 129
ALA A  97
 None
 1.04A 1nv8A-4rshA:
3.5		 1nv8A-4rshA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		4 / 7 GLY A  60
GLN A  95
ARG A 103
ILE A 118
 None
 1.08A 1rxcD-4rshA:
undetectable		 1rxcD-4rshA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		6 / 12 THR A  64
ILE A 126
GLY A 123
GLY A 121
VAL A 129
ALA A  97
 None
 1.48A 1sg9B-4rshA:
undetectable		 1sg9B-4rshA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		5 / 12 GLY A 220
TYR A 216
GLY A 215
ALA A 223
LEU A 227
 None
 1.04A 2plwA-4rshA:
2.0		 2plwA-4rshA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		4 / 6 GLY A  60
GLN A  95
ARG A 103
ILE A 118
 None
 1.10A 3kvvA-4rshA:
undetectable		 3kvvA-4rshA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		4 / 6 GLY A  60
GLN A  95
ARG A 103
ILE A 118
 None
 1.12A 3kvvB-4rshA:
undetectable		 3kvvB-4rshA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		4 / 6 GLY A  60
GLN A  95
ARG A 103
ILE A 118
 None
 1.10A 3kvvC-4rshA:
2.2		 3kvvC-4rshA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		4 / 6 GLY A  60
GLN A  95
ARG A 103
ILE A 118
 None
 1.12A 3kvvD-4rshA:
undetectable		 3kvvD-4rshA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		4 / 6 GLY A 220
VAL A  78
PRO A  76
GLY A  66
 None
 0.81A 4dxuA-4rshA:
undetectable		 4dxuA-4rshA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		4 / 7 GLY A 220
VAL A  78
PRO A  76
GLY A  66
 None
 0.81A 4forA-4rshA:
undetectable		 4forA-4rshA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 200
GLU A 207
GLY A 215
PHE A  63
LEU A 158
 None
 1.20A 4hytA-4rshA:
undetectable		 4hytA-4rshA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 200
GLU A 207
GLY A 215
PHE A  63
LEU A 158
 None
 1.20A 4hytC-4rshA:
undetectable		 4hytC-4rshA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		4 / 4 ALA A 155
VAL A 120
GLY A  91
THR A  64
 None
 1.06A 4ubeA-4rshA:
6.0		 4ubeA-4rshA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		4 / 7 PHE A 188
GLU A 221
SER A 224
VAL A  78
 None
 1.44A 5adlA-4rshA:
undetectable
5adlB-4rshA:
1.4		 5adlA-4rshA:
17.57
5adlB-4rshA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		5 / 11 PHE A 170
ILE A 167
ASN A 197
ASP A 187
LEU A 156
 None
 1.33A 5fctA-4rshA:
undetectable		 5fctA-4rshA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 4rsh LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Desulfitobacteri
um
hafniense) 		3 / 3 ILE A 167
THR A 166
PRO A 157
 None
 0.61A 6ncsA-4rshA:
3.6		 6ncsA-4rshA:
19.31