SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rsi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 626
LEU A 552
VAL A 527
GLY A 528
ILE A 612
 None
 1.24A 2a1oB-4rsiA:
undetectable		 2a1oB-4rsiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 692
ASP B 715
ALA B 778
ILE B 742
 None
 0.82A 2aofB-4rsiB:
undetectable		 2aofB-4rsiB:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 697
VAL A 700
THR A 701
ASP A 484
 None
 0.93A 2qblA-4rsiA:
undetectable		 2qblA-4rsiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 624
GLY A 549
GLY A 550
ASN A 554
 None
 0.73A 2qr2A-4rsiA:
undetectable
2qr2B-4rsiA:
undetectable		 2qr2A-4rsiA:
19.46
2qr2B-4rsiA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 680
LEU A 552
VAL A 504
VAL A 526
ILE A 625
 None
 1.14A 2vn0A-4rsiA:
undetectable		 2vn0A-4rsiA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 THR B 820
VAL A 576
VAL A 527
VAL A 526
 None
 0.95A 2z97A-4rsiB:
undetectable		 2z97A-4rsiB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 693
ASP B 703
ILE B 706
ASP B 715
LEU B 713
 None
 1.34A 3iv6B-4rsiB:
undetectable		 3iv6B-4rsiB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Saccharomyces
cerevisiae) 		4 / 5 HIS B 873
THR B 871
GLU B 877
ASP B 884
 None
 1.27A 3tm4A-4rsiB:
undetectable		 3tm4A-4rsiB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Saccharomyces
cerevisiae) 		4 / 5 HIS B 873
THR B 871
GLU B 877
ASP B 884
 None
 1.29A 3tm4B-4rsiB:
undetectable		 3tm4B-4rsiB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG B 653
GLN B 646
GLU A 498
 None
 0.88A 4tvtA-4rsiB:
undetectable		 4tvtA-4rsiB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 THR A 637
TYR A 659
THR A 642
VAL B 721
 None
 1.29A 5ov9B-4rsiA:
undetectable		 5ov9B-4rsiA:
20.22