SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rsm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLN A  99
PRO A 164
GLU A 170
ASP A 101
 None
 1.04A 1dtlA-4rsmA:
undetectable		 1dtlA-4rsmA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ARG A 318
THR A 272
VAL A 273
ALA A 310
 None
 1.09A 1fo4B-4rsmA:
1.1		 1fo4B-4rsmA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASP A 249
GLY A 163
ALA A 140
ILE A 248
 3VB  A 401 (-2.7A)
None
None
None
 0.86A 2aofA-4rsmA:
undetectable		 2aofA-4rsmA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 5 SER A 238
ARG A 240
PRO A 215
GLY A 214
 None
 1.29A 2y7kB-4rsmA:
2.5		 2y7kB-4rsmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER A 238
ARG A 240
PRO A 215
GLY A 214
 None
 1.30A 2y7pA-4rsmA:
2.9		 2y7pA-4rsmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 7 VAL A 203
LYS A 207
ILE A 210
GLY A 214
 None
 0.75A 3bjwB-4rsmA:
undetectable		 3bjwB-4rsmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 254
SER A  46
VAL A 314
LEU A 229
ASP A 253
 None
 1.27A 3d91B-4rsmA:
undetectable		 3d91B-4rsmA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLN A 269
MET A 299
SER A  45
SER A  46
 3VB  A 401 (-3.1A)
None
3VB  A 401 ( 4.7A)
None
 1.04A 3pmzD-4rsmA:
undetectable		 3pmzD-4rsmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A 141
ILE A 177
GLN A 223
VAL A 246
 None
 1.08A 4d39B-4rsmA:
undetectable		 4d39B-4rsmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 245
GLY A 265
PHE A 263
MET A 148
ALA A 149
 None
 1.25A 4eb4B-4rsmA:
undetectable		 4eb4B-4rsmA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 7 VAL A  96
SER A  45
TYR A  42
LEU A 275
 None
3VB  A 401 ( 4.7A)
3VB  A 401 (-4.5A)
None
 1.21A 4hxyB-4rsmA:
undetectable		 4hxyB-4rsmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A 141
ILE A 177
GLN A 223
VAL A 246
 None
 1.06A 4kcnA-4rsmA:
undetectable		 4kcnA-4rsmA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PRO A 300
ALA A 310
ILE A 329
LEU A 275
GLY A 278
 None
 1.19A 4l9qB-4rsmA:
undetectable		 4l9qB-4rsmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLU A 341
ALA A 339
ALA A 276
ALA A 277
ILE A 329
 None
 1.10A 4lbgB-4rsmA:
4.1		 4lbgB-4rsmA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASN A 306
GLY A 250
ASN A 256
GLY A 228
SER A 267
 None
 1.26A 4obwC-4rsmA:
2.4		 4obwC-4rsmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASN A  72
ASP A  43
ASP A 200
 None
 0.83A 4obwD-4rsmA:
undetectable		 4obwD-4rsmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 232
LEU A 229
GLY A 230
LEU A 161
VAL A 246
 None
 1.21A 4olmA-4rsmA:
undetectable		 4olmA-4rsmA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A  93
ILE A  86
ASP A  83
VAL A  96
LEU A 103
 None
 1.44A 5jkwA-4rsmA:
undetectable		 5jkwA-4rsmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLU A 312
THR A 316
THR A 272
LEU A 268
 None
 1.50A 5v96A-4rsmA:
5.0		 5v96A-4rsmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 335
GLY A 336
LEU A 333
VAL A 291
GLY A 342
 None
 1.20A 6gngA-4rsmA:
3.5		 6gngA-4rsmA:
21.45