SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rt6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 4 THR A  34
PRO A  32
THR A  33
PRO A  54
 None
 1.21A 1a7yA-4rt6A:
undetectable
1a7yC-4rt6A:
undetectable		 1a7yA-4rt6A:
1.82
1a7yC-4rt6A:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
HEMOPEXIN
(Haemophilus
influenzae;
Oryctolagus
cuniculus) 		4 / 8 GLY B 135
THR B 150
LEU A 552
ASP A 551
 None
 0.83A 1aegA-4rt6B:
undetectable		 1aegA-4rt6B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 9 PHE A 471
ILE A 430
ASP A 374
GLY A 399
ASN A 397
 None
 1.17A 1i00B-4rt6A:
undetectable		 1i00B-4rt6A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 10 ASP A 511
LEU A 597
GLY A 512
TYR A 509
ALA A 557
 None
 1.46A 1ju6C-4rt6A:
undetectable		 1ju6C-4rt6A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 11 ASP A 511
LEU A 597
GLY A 512
TYR A 509
ALA A 557
 None
 1.46A 1ju6D-4rt6A:
undetectable		 1ju6D-4rt6A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 8 SER A 410
ASN A 438
GLY A 442
GLY A 388
 None
 0.73A 1me7A-4rt6A:
undetectable		 1me7A-4rt6A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
HEMOPEXIN
(Haemophilus
influenzae;
Oryctolagus
cuniculus) 		5 / 12 LEU B 137
HIS A 560
ASP B 148
LEU A 552
PHE B 146
 None
 1.30A 1uobA-4rt6B:
undetectable		 1uobA-4rt6B:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 7 ILE A 642
ILE A 746
ILE A 794
PHE A 682
 None
 0.88A 1uwjA-4rt6A:
undetectable		 1uwjA-4rt6A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 11 VAL A 375
ILE A 401
LEU A 395
LEU A 358
LEU A 393
 None
 1.26A 2a15A-4rt6A:
undetectable		 2a15A-4rt6A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 LEU A 255
ILE A 279
ILE A 301
ASN A 365
LEU A 361
 None
 1.01A 2bdmA-4rt6A:
undetectable		 2bdmA-4rt6A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 9 PHE A 150
ASN A 141
ILE A 145
ALA A 147
VAL A 100
 None
 1.30A 2drdA-4rt6A:
undetectable		 2drdA-4rt6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 SER A 519
ASP A 511
GLY A 513
TYR A 509
ALA A 557
 None
 1.31A 2kceA-4rt6A:
undetectable		 2kceA-4rt6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 5 LEU A 358
ALA A 363
ILE A 383
SER A 391
 None
 1.14A 2othA-4rt6A:
undetectable		 2othA-4rt6A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		3 / 3 PHE A 182
SER A 175
LEU A 153
 None
 0.81A 2w1bA-4rt6A:
undetectable		 2w1bA-4rt6A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 9 VAL A  90
GLY A  89
GLY A 137
LEU A 153
ALA A 105
 None
 0.94A 2z0yB-4rt6A:
undetectable		 2z0yB-4rt6A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 9 VAL A 158
VAL A  90
GLY A  89
GLY A 137
ALA A 105
 None
 0.97A 2z0yB-4rt6A:
undetectable		 2z0yB-4rt6A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 7 VAL A  82
LEU A  76
ILE A  36
ASN A  62
 None
 1.05A 3avpA-4rt6A:
undetectable		 3avpA-4rt6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rt6 HEMOPEXIN
(Oryctolagus
cuniculus) 		5 / 10 ILE B  88
ALA B  76
ALA B  77
PHE B 138
ALA B 122
 None
 1.03A 3falA-4rt6B:
undetectable		 3falA-4rt6B:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 10 LEU A 358
VAL A 375
ILE A 401
ILE A 432
PHE A 416
 None
 1.22A 3kz7A-4rt6A:
undetectable		 3kz7A-4rt6A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLN A 254
GLY A 356
ALA A 357
SER A 360
LEU A 361
 None
 1.01A 3ln1A-4rt6A:
undetectable		 3ln1A-4rt6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLN A 254
GLY A 356
ALA A 357
SER A 360
LEU A 361
 None
 0.99A 3ln1B-4rt6A:
undetectable		 3ln1B-4rt6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 6 PHE A 124
TYR A  83
VAL A  13
THR A  33
 None
 1.29A 3ltwA-4rt6A:
undetectable		 3ltwA-4rt6A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 5 PHE A 682
MET A 629
ASN A 630
PHE A 673
 None
 1.15A 3octA-4rt6A:
undetectable		 3octA-4rt6A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLY A 491
ASP A 511
TYR A 509
LYS A 494
ILE A 580
 None
 1.18A 3opeA-4rt6A:
undetectable		 3opeA-4rt6A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLY A 711
ASP A 726
ARG A 683
GLY A 708
ALA A 730
 None
 1.18A 3sueB-4rt6A:
undetectable		 3sueB-4rt6A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLY A 711
ASP A 726
ARG A 683
GLY A 708
ALA A 730
 None
 1.17A 3sueD-4rt6A:
undetectable		 3sueD-4rt6A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
HEMOPEXIN
(Haemophilus
influenzae;
Oryctolagus
cuniculus) 		3 / 3 ARG A 785
PRO B 195
PHE A 789
 None
 0.87A 3thrC-4rt6A:
undetectable		 3thrC-4rt6A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 5 TYR A 523
SER A 515
ASP A 511
ILE A 580
 None
 1.31A 3uj7B-4rt6A:
undetectable		 3uj7B-4rt6A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 4rt6 HEMOPEXIN
(Oryctolagus
cuniculus) 		4 / 5 ASP B  34
GLU B  50
GLY B  72
ASP B  75
 None
 1.41A 3w9tD-4rt6B:
undetectable		 3w9tD-4rt6B:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 9 ILE A 601
GLY A 631
VAL A 594
GLY A 628
ARG A 531
 None
 1.31A 4acaB-4rt6A:
undetectable
4acaC-4rt6A:
undetectable		 4acaB-4rt6A:
21.09
4acaC-4rt6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 PHE A 471
ILE A 430
ASP A 374
GLY A 399
ASN A 397
 None
 1.19A 4eb4A-4rt6A:
undetectable		 4eb4A-4rt6A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 PHE A 471
ILE A 430
ASP A 374
GLY A 399
ASN A 397
 None
 1.18A 4eb4B-4rt6A:
undetectable		 4eb4B-4rt6A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 10 PHE A 471
ILE A 430
ASP A 374
GLY A 399
ASN A 397
 None
 1.19A 4eb4D-4rt6A:
undetectable		 4eb4D-4rt6A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 11 LEU A 361
PHE A 305
LEU A 358
VAL A 375
VAL A 299
 None
 1.50A 4mk4B-4rt6A:
undetectable		 4mk4B-4rt6A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 ASP A 484
GLY A 592
PHE A 593
ASP A 619
THR A 622
 None
 1.11A 4mm8A-4rt6A:
undetectable		 4mm8A-4rt6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 8 PHE A 180
TYR A  83
PHE A 182
ILE A 164
 None
 0.99A 4qoiA-4rt6A:
undetectable
4qoiB-4rt6A:
undetectable		 4qoiA-4rt6A:
13.01
4qoiB-4rt6A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 6 LEU A 627
LEU A 589
ILE A 510
PHE A 508
 None
 1.12A 4y4dA-4rt6A:
undetectable		 4y4dA-4rt6A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLY A 491
ASP A 511
TYR A 509
LYS A 494
ILE A 580
 None
 1.30A 4ynpA-4rt6A:
undetectable		 4ynpA-4rt6A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 8 SER A 385
GLY A 412
ILE A 437
GLY A 442
 None
 0.85A 5alcL-4rt6A:
undetectable		 5alcL-4rt6A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 PHE A 269
LEU A 248
ILE A 213
SER A 259
VAL A 202
 None
 1.46A 5h1eA-4rt6A:
undetectable		 5h1eA-4rt6A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLN A 254
GLY A 356
ALA A 357
SER A 360
LEU A 361
 None
 0.83A 5kirA-4rt6A:
undetectable		 5kirA-4rt6A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLN A 254
GLY A 356
ALA A 357
SER A 360
LEU A 361
 None
 0.90A 5kirB-4rt6A:
undetectable		 5kirB-4rt6A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 9 VAL A 594
ILE A 642
LEU A 627
ILE A 640
ALA A 502
 None
 0.99A 5nunA-4rt6A:
undetectable		 5nunA-4rt6A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 4rt6 HEMOPEXIN
(Oryctolagus
cuniculus) 		3 / 3 LYS B  54
TRP B  53
SER B  55
 None
 1.21A 5nwwA-4rt6B:
undetectable		 5nwwA-4rt6B:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 6 ARG A 808
PHE A 781
ILE A 704
THR A 702
 None
 1.08A 5vceA-4rt6A:
undetectable		 5vceA-4rt6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 5 PHE A 415
PHE A 416
LEU A 439
LEU A 528
 None
 1.34A 5veuH-4rt6A:
undetectable		 5veuH-4rt6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 6 ILE A 608
ILE A 690
LEU A 699
PHE A 778
 None
 0.94A 5vkqA-4rt6A:
undetectable
5vkqB-4rt6A:
undetectable		 5vkqA-4rt6A:
20.34
5vkqB-4rt6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 6 PHE A 778
ILE A 608
ILE A 690
LEU A 699
 None
 0.90A 5vkqA-4rt6A:
undetectable
5vkqD-4rt6A:
undetectable		 5vkqA-4rt6A:
20.34
5vkqD-4rt6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
HEMOPEXIN
(Haemophilus
influenzae;
Oryctolagus
cuniculus) 		3 / 3 THR B 151
THR B 153
ARG A 516
 None
 0.99A 5wm2A-4rt6B:
undetectable		 5wm2A-4rt6B:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 PHE A 471
ILE A 430
ASP A 374
GLY A 399
ASN A 397
 None
 1.13A 5x66A-4rt6A:
undetectable
5x66B-4rt6A:
undetectable		 5x66A-4rt6A:
15.16
5x66B-4rt6A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 9 ASP A 511
LEU A 597
GLY A 512
TYR A 509
ALA A 557
 None
 1.37A 5x66C-4rt6A:
undetectable		 5x66C-4rt6A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 10 PHE A 471
ILE A 430
ASP A 374
GLY A 399
ASN A 397
 None
 1.12A 5x66D-4rt6A:
undetectable		 5x66D-4rt6A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 8 ILE A 510
LEU A 497
ALA A 502
LEU A 589
 None
 0.82A 5y7pE-4rt6A:
undetectable		 5y7pE-4rt6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 7 SER A 410
SER A 385
GLY A 388
LEU A 362
 None
 0.94A 6btxA-4rt6A:
undetectable		 6btxA-4rt6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		4 / 6 ASP A 309
ASN A 364
LEU A 321
SER A 389
 None
 1.18A 6ekuA-4rt6A:
undetectable		 6ekuA-4rt6A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 LEU A 596
ILE A 601
GLY A 631
ILE A 510
ILE A 580
 None
 0.92A 6emuB-4rt6A:
undetectable		 6emuB-4rt6A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 LEU A 370
ILE A 335
GLY A 372
ASP A 328
ILE A 327
 None
 1.09A 6emuC-4rt6A:
undetectable		 6emuC-4rt6A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		5 / 12 LEU A 596
ILE A 601
GLY A 631
ILE A 510
ILE A 580
 None
 0.92A 6emuC-4rt6A:
undetectable		 6emuC-4rt6A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN
(Haemophilus
influenzae) 		3 / 3 ASP A 529
LEU A 528
ARG A 468
 None
 0.84A 7dfrA-4rt6A:
undetectable		 7dfrA-4rt6A:
10.46