SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rtb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 10 ALA A 248
ASP A 249
ILE A   5
GLY A 243
PHE A 187
 None
None
None
None
SAM  A 501 (-4.3A)
 1.21A 1d4sA-4rtbA:
undetectable		 1d4sA-4rtbA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 4 ILE A  30
LEU A 238
VAL A  16
ILE A  43
 None
 0.88A 1fm6D-4rtbA:
undetectable		 1fm6D-4rtbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 4 ILE A 148
LEU A 176
VAL A 163
ILE A 161
 None
 0.85A 1fm6D-4rtbA:
undetectable		 1fm6D-4rtbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 PHE A  61
ALA A 291
VAL A  16
LEU A 242
HIS A 284
 None
 1.04A 1hbpA-4rtbA:
undetectable		 1hbpA-4rtbA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 ILE A  30
LEU A 241
MET A 296
LEU A  60
ASP A 236
 None
 1.48A 1mrlA-4rtbA:
undetectable
1mrlB-4rtbA:
undetectable		 1mrlA-4rtbA:
20.04
1mrlB-4rtbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		3 / 3 CYH A 372
ARG A 128
CYH A 375
 None
CL  A 503 (-3.0A)
None
 1.36A 1p9gA-4rtbA:
undetectable		 1p9gA-4rtbA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 6 PHE A  79
ALA A  80
LEU A 130
SER A 325
 None
None
None
CL  A 507 (-4.7A)
 1.05A 1sbrA-4rtbA:
undetectable
1sbrB-4rtbA:
undetectable		 1sbrA-4rtbA:
17.11
1sbrB-4rtbA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		3 / 3 LEU A 428
TYR A 427
GLN A 430
 None
 0.63A 2wekA-4rtbA:
undetectable		 2wekA-4rtbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 8 TYR A  94
LEU A 234
ALA A 230
HIS A 200
 SAM  A 501 (-4.5A)
None
None
None
 1.08A 2wekA-4rtbA:
undetectable		 2wekA-4rtbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 7 TYR A 250
LEU A 251
ASN A 213
TYR A 173
 None
 1.36A 4f8yC-4rtbA:
undetectable
4f8yD-4rtbA:
undetectable		 4f8yC-4rtbA:
16.81
4f8yD-4rtbA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 9 ILE A 245
ILE A 289
MET A 296
ILE A  47
VAL A  16
 None
 1.17A 4nptA-4rtbA:
undetectable		 4nptA-4rtbA:
14.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		6 / 12 TYR A  94
CYH A  95
LYS A 205
LEU A 234
LEU A 267
ALA A 270
 SAM  A 501 (-4.5A)
SF4  A 502 ( 2.7A)
SAM  A 501 (-3.3A)
None
SAM  A 501 (-4.4A)
SAM  A 501 ( 3.7A)
 1.43A 4rtbA-4rtbA:
71.5		 4rtbA-4rtbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		12 / 12 TYR A  94
CYH A  95
VAL A 132
ASN A 164
LEU A 186
PHE A 187
LYS A 205
LEU A 231
LEU A 267
LYS A 268
ALA A 270
PHE A 347
 SAM  A 501 (-4.5A)
SF4  A 502 ( 2.7A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.5A)
None
SAM  A 501 (-4.3A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.4A)
None
SAM  A 501 ( 3.7A)
SAM  A 501 (-4.8A)
 0.01A 4rtbA-4rtbA:
71.5		 4rtbA-4rtbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		3 / 3 GLU A 189
ARG A 211
GLN A 346
 SAM  A 501 (-2.4A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.1A)
 0.01A 4rtbA-4rtbA:
71.5		 4rtbA-4rtbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		8 / 12 TYR A  94
GLY A 134
GLU A 135
PHE A 187
LEU A 231
PRO A 265
LEU A 267
ALA A 270
 SAM  A 501 (-4.5A)
SF4  A 502 ( 3.9A)
None
SAM  A 501 (-4.3A)
SAM  A 501 (-4.1A)
None
SAM  A 501 (-4.4A)
SAM  A 501 ( 3.7A)
 0.39A 4wcxC-4rtbA:
46.2		 4wcxC-4rtbA:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 6 CYH A  95
ASN A 164
LEU A 186
GLU A 189
LYS A 205
 SF4  A 502 ( 2.7A)
SAM  A 501 (-3.5A)
None
SAM  A 501 (-2.4A)
SAM  A 501 (-3.3A)
 0.40A 4wcxC-4rtbA:
46.2		 4wcxC-4rtbA:
43.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 ALA A  64
VAL A  67
TYR A  72
SER A 322
GLY A 320
 None
 1.21A 4xnxA-4rtbA:
undetectable		 4xnxA-4rtbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 TYR A  94
CYH A  95
LEU A 186
ARG A 211
TYR A  83
 SAM  A 501 (-4.5A)
SF4  A 502 ( 2.7A)
None
SAM  A 501 (-2.7A)
None
 0.95A 5fepA-4rtbA:
34.1		 5fepA-4rtbA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 12 TYR A  94
CYH A  95
LEU A 186
ARG A 211
TYR A  83
 SAM  A 501 (-4.5A)
SF4  A 502 ( 2.7A)
None
SAM  A 501 (-2.7A)
None
 0.99A 5fesA-4rtbA:
34.0		 5fesA-4rtbA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		3 / 3 TYR A 335
ARG A 329
THR A 330
 None
 0.99A 5z84J-4rtbA:
undetectable		 5z84J-4rtbA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4rtb HYDG PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 8 VAL A  19
ILE A  43
THR A  12
TYR A  13
 None
 0.94A 6cduG-4rtbA:
undetectable
6cduH-4rtbA:
undetectable		 6cduG-4rtbA:
21.29
6cduH-4rtbA:
21.29