SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rtf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.14A 1c8lA-4rtfD:
undetectable		 1c8lA-4rtfD:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.10A 1gfzA-4rtfD:
undetectable		 1gfzA-4rtfD:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.09A 1l5qA-4rtfD:
undetectable		 1l5qA-4rtfD:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.08A 1l5qB-4rtfD:
undetectable		 1l5qB-4rtfD:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.04A 1l7xA-4rtfD:
undetectable		 1l7xA-4rtfD:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.06A 1l7xB-4rtfD:
undetectable		 1l7xB-4rtfD:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		5 / 12 ASP D 202
ASN D  13
GLY D 174
VAL D 345
ASP D   8
 None
None
None
None
ATP  D 601 (-3.6A)
 1.46A 2fqyA-4rtfD:
undetectable		 2fqyA-4rtfD:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 5 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.16A 3bcrA-4rtfD:
undetectable		 3bcrA-4rtfD:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.11A 3dd1A-4rtfD:
undetectable		 3dd1A-4rtfD:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.08A 3dd1B-4rtfD:
undetectable		 3dd1B-4rtfD:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.10A 3ddsA-4rtfD:
undetectable		 3ddsA-4rtfD:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.07A 3ddsB-4rtfD:
undetectable		 3ddsB-4rtfD:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.11A 3ddwA-4rtfD:
undetectable		 3ddwA-4rtfD:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 6 ASN D 123
PHE D 122
ALA D 125
GLY D  74
 None
 1.09A 3ddwB-4rtfD:
undetectable		 3ddwB-4rtfD:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		5 / 11 LEU D 224
LEU D 255
ASN D 254
ALA D 237
VAL D 209
 None
 1.16A 3e22B-4rtfD:
undetectable		 3e22B-4rtfD:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		5 / 11 LEU D 224
LEU D 255
ASN D 254
ALA D 237
VAL D 209
 None
 1.18A 3e22D-4rtfD:
undetectable		 3e22D-4rtfD:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 5 VAL D 213
LEU D 212
ILE D 258
ALA D 230
 None
 0.92A 3n8yB-4rtfD:
1.0		 3n8yB-4rtfD:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 4 ILE D 243
SER D 246
ASP D 205
ASP D 210
 None
 1.47A 4krhB-4rtfD:
undetectable		 4krhB-4rtfD:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		5 / 12 ASP D 177
ALA D 152
VAL D 311
SER D 179
THR D 117
 ATP  D 601 ( 4.5A)
None
None
None
None
 1.06A 4mm4B-4rtfD:
undetectable		 4mm4B-4rtfD:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		4 / 7 GLU D 147
THR D  11
GLY D  10
THR D  12
 ATP  D 601 (-2.6A)
ATP  D 601 (-3.3A)
ATP  D 601 (-3.0A)
None
 0.90A 4qwpB-4rtfD:
undetectable		 4qwpB-4rtfD:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		8 / 10 GLY D 173
GLY D 201
GLU D 239
LYS D 242
SER D 246
GLY D 315
SER D 316
ARG D 318
 None
 0.87A 5aqfA-4rtfD:
46.7		 5aqfA-4rtfD:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		6 / 10 GLY D 172
GLY D 201
SER D 246
GLY D 315
SER D 316
ARG D 318
 ATP  D 601 ( 3.9A)
None
None
None
None
None
 1.08A 5aqfC-4rtfD:
46.3		 5aqfC-4rtfD:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		8 / 10 GLY D 173
GLY D 201
GLU D 239
LYS D 242
SER D 246
GLY D 315
SER D 316
ARG D 318
 None
 0.84A 5aqfC-4rtfD:
46.3		 5aqfC-4rtfD:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		7 / 10 GLY D 172
GLY D 201
LYS D 242
SER D 246
GLY D 315
SER D 316
ARG D 318
 ATP  D 601 ( 3.9A)
None
None
None
None
None
None
 1.07A 5aqyA-4rtfD:
48.5		 5aqyA-4rtfD:
35.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		8 / 10 GLY D 173
GLY D 201
GLU D 239
LYS D 242
SER D 246
GLY D 315
SER D 316
ARG D 318
 None
 0.86A 5aqyA-4rtfD:
48.5		 5aqyA-4rtfD:
35.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		5 / 12 GLY D  10
SER D 179
VAL D 168
VAL D 313
ASP D 342
 ATP  D 601 (-3.0A)
None
None
None
None
 1.35A 6bxlB-4rtfD:
undetectable		 6bxlB-4rtfD:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4rtf CHAPERONE PROTEIN
DNAK
(Mycobacterium
tuberculosis) 		5 / 12 LEU D 351
GLY D 348
LEU D 139
ILE D 116
ASP D   8
 None
None
None
None
ATP  D 601 (-3.6A)
 1.24A 6bxmA-4rtfD:
undetectable		 6bxmA-4rtfD:
21.45