SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ru1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		4 / 8 THR A 203
CYH A 191
TYR A 202
LEU A 179
 None
 1.41A 1uw6A-4ru1A:
undetectable
1uw6B-4ru1A:
undetectable		 1uw6A-4ru1A:
20.13
1uw6B-4ru1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		4 / 8 THR A 203
CYH A 191
TYR A 202
LEU A 179
 None
 1.47A 1uw6D-4ru1A:
undetectable
1uw6E-4ru1A:
undetectable		 1uw6D-4ru1A:
20.13
1uw6E-4ru1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		4 / 8 THR A 203
CYH A 191
TYR A 202
LEU A 179
 None
 1.43A 1uw6G-4ru1A:
undetectable
1uw6H-4ru1A:
undetectable		 1uw6G-4ru1A:
20.13
1uw6H-4ru1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		4 / 8 THR A 203
CYH A 191
TYR A 202
LEU A 179
 None
 1.43A 1uw6P-4ru1A:
undetectable
1uw6Q-4ru1A:
undetectable		 1uw6P-4ru1A:
20.13
1uw6Q-4ru1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		5 / 12 GLY A 200
ASP A 230
GLY A 164
ALA A 167
ALA A 257
 None
 1.03A 3sudD-4ru1A:
undetectable		 3sudD-4ru1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		5 / 11 ILE A 113
ALA A 135
GLY A 286
HIS A  57
GLU A  94
 None
None
None
INS  A 401 (-4.2A)
None
 1.45A 4j83A-4ru1A:
undetectable		 4j83A-4ru1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		3 / 3 ASP A 291
TYR A 287
TRP A 294
 None
 0.83A 4p7nA-4ru1A:
undetectable		 4p7nA-4ru1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		4 / 8 ARG A 190
GLU A 156
GLY A 312
PRO A 313
 INS  A 401 (-2.6A)
None
None
None
 1.01A 5kgpA-4ru1A:
undetectable		 5kgpA-4ru1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		4 / 8 ARG A 190
GLU A 156
GLY A 312
PRO A 313
 INS  A 401 (-2.6A)
None
None
None
 1.03A 5kgpB-4ru1A:
undetectable		 5kgpB-4ru1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		5 / 12 SER A 292
LEU A 293
THR A 311
ALA A 308
GLY A 139
 None
 1.14A 5veuA-4ru1A:
undetectable		 5veuA-4ru1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		5 / 12 ASP A 279
ARG A 190
ALA A 159
GLY A 153
GLY A 312
 None
INS  A 401 (-2.6A)
None
None
None
 0.97A 6clxA-4ru1A:
2.2		 6clxA-4ru1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4ru1 MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY
(Acidothermus
cellulolyticus) 		4 / 8 GLY A 193
GLN A 161
THR A 197
PHE A 259
 None
 0.96A 6eqpA-4ru1A:
2.8		 6eqpA-4ru1A:
12.67