SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ru4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 5 GLY A 382
LEU A 407
THR A 406
VAL A 278
 None
None
NA  A 804 ( 4.8A)
None
 0.78A 1ekjF-4ru4A:
undetectable
1ekjG-4ru4A:
undetectable		 1ekjF-4ru4A:
16.86
1ekjG-4ru4A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 4 ILE A 317
LEU A 309
VAL A 348
ILE A 350
 None
 0.78A 1fm6D-4ru4A:
undetectable		 1fm6D-4ru4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 6 TYR A 623
VAL A 539
ILE A 538
LEU A 633
 None
 1.19A 1j96A-4ru4A:
undetectable		 1j96A-4ru4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 7 TYR A 623
VAL A 539
ILE A 538
LEU A 633
 None
 1.09A 1j96B-4ru4A:
undetectable		 1j96B-4ru4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 4 PHE A 442
ASP A 497
PHE A 498
VAL A 478
 None
 1.49A 1w0fA-4ru4A:
undetectable		 1w0fA-4ru4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 8 PHE A 303
SER A 305
ALA A 287
LEU A 288
 None
 1.07A 2o01A-4ru4A:
undetectable		 2o01A-4ru4A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 6 PHE A 589
TRP A 518
GLY A 573
GLY A 574
 None
 0.81A 2qr2A-4ru4A:
undetectable
2qr2B-4ru4A:
undetectable		 2qr2A-4ru4A:
16.33
2qr2B-4ru4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 5 TRP A 518
GLY A 573
GLY A 574
PHE A 589
 None
 0.93A 2qr2A-4ru4A:
undetectable
2qr2B-4ru4A:
undetectable		 2qr2A-4ru4A:
16.33
2qr2B-4ru4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		5 / 12 LEU A 227
GLN A 228
SER A 265
ILE A 378
LEU A 279
 None
 1.45A 3ia4A-4ru4A:
undetectable		 3ia4A-4ru4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		3 / 3 ASN A 430
ASP A 433
ARG A 329
 None
 0.90A 3k13A-4ru4A:
undetectable		 3k13A-4ru4A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 7 TYR A 707
PHE A 703
VAL A 701
GLY A 683
 None
 0.89A 3kmoB-4ru4A:
undetectable		 3kmoB-4ru4A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		5 / 12 GLY A 389
ALA A 411
ASN A 430
ILE A 380
LEU A 391
 None
 1.28A 4azsA-4ru4A:
undetectable		 4azsA-4ru4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		5 / 12 GLY A 389
ASN A 409
ILE A 380
LEU A 391
ILE A 267
 None
 1.13A 4aztA-4ru4A:
undetectable		 4aztA-4ru4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		6 / 12 GLY A 389
ASN A 409
ILE A 380
LEU A 391
SER A 280
ILE A 267
 None
 1.48A 4azvA-4ru4A:
undetectable		 4azvA-4ru4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 8 SER A 506
LEU A 590
LEU A 550
SER A 524
 None
 0.58A 4iklA-4ru4A:
undetectable
4iklB-4ru4A:
undetectable		 4iklA-4ru4A:
10.98
4iklB-4ru4A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 8 HIS A 238
ALA A 376
SER A 265
ASP A 261
 None
 0.99A 4k0bB-4ru4A:
undetectable		 4k0bB-4ru4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 8 HIS A 238
ALA A 376
SER A 265
ASP A 261
 None
 1.01A 4l7iB-4ru4A:
undetectable		 4l7iB-4ru4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		5 / 9 PHE A 589
ILE A 540
GLY A 574
SER A 615
VAL A 578
 None
 1.24A 4r20B-4ru4A:
undetectable		 4r20B-4ru4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 7 THR A 464
GLY A 500
ALA A 502
ILE A 523
 None
 0.74A 4txnA-4ru4A:
undetectable		 4txnA-4ru4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 7 THR A 464
GLY A 500
ALA A 502
ILE A 523
 None
 0.81A 4txnB-4ru4A:
undetectable		 4txnB-4ru4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 7 THR A 464
GLY A 500
ALA A 502
ILE A 523
 None
 0.80A 4txnC-4ru4A:
undetectable		 4txnC-4ru4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 7 THR A 464
GLY A 500
ALA A 502
ILE A 523
 None
 0.79A 4txnD-4ru4A:
undetectable		 4txnD-4ru4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		5 / 12 TYR A 623
VAL A 539
ILE A 538
LEU A 633
LEU A 601
 None
 1.19A 4yvpB-4ru4A:
undetectable		 4yvpB-4ru4A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		5 / 11 VAL A 395
GLY A 448
GLY A 449
MET A 480
ILE A 423
 None
 1.20A 4zvmA-4ru4A:
undetectable
4zvmB-4ru4A:
undetectable		 4zvmA-4ru4A:
16.33
4zvmB-4ru4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 5 PHE A 442
ILE A 423
GLY A 448
ILE A 440
 None
 0.86A 5dzkB-4ru4A:
undetectable
5dzkI-4ru4A:
undetectable
5dzkW-4ru4A:
undetectable		 5dzkB-4ru4A:
16.06
5dzkI-4ru4A:
14.72
5dzkW-4ru4A:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		5 / 12 GLY A 260
GLY A 242
SER A 241
ASP A 243
ARG A 268
 None
 1.07A 5hikA-4ru4A:
undetectable		 5hikA-4ru4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		5 / 12 TYR A 318
VAL A 470
GLU A 336
ALA A 364
GLY A 360
 None
 1.05A 5igjA-4ru4A:
undetectable		 5igjA-4ru4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		5 / 12 LEU A 682
ALA A 764
PHE A 703
ARG A 685
LEU A 742
 None
 1.15A 5nd7B-4ru4A:
undetectable		 5nd7B-4ru4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 8 ASP A 497
HIS A 460
HIS A 494
HIS A 499
 None
 0.92A 5nekD-4ru4A:
undetectable		 5nekD-4ru4A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		3 / 3 HIS A 499
ASP A 497
HIS A 460
 None
 0.65A 5oexA-4ru4A:
undetectable		 5oexA-4ru4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		3 / 3 HIS A 499
ASP A 497
HIS A 460
 None
 0.67A 5oexB-4ru4A:
undetectable		 5oexB-4ru4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		3 / 3 HIS A 499
ASP A 497
HIS A 460
 None
 0.71A 5oexC-4ru4A:
undetectable		 5oexC-4ru4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		3 / 3 HIS A 499
ASP A 497
HIS A 460
 None
 0.68A 5oexD-4ru4A:
undetectable		 5oexD-4ru4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		3 / 3 TYR A 456
ASP A 437
ASP A 488
 None
 0.83A 5x6yA-4ru4A:
undetectable		 5x6yA-4ru4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		4 / 7 LEU A 545
THR A 584
TYR A 332
PHE A 328
 None
 0.94A 5zsfA-4ru4A:
2.4
5zsfB-4ru4A:
3.9		 5zsfA-4ru4A:
9.35
5zsfB-4ru4A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4ru4 TAIL SPIKE PROTEIN
GP49
(Pseudomonas
virus
LKA1) 		5 / 10 LEU A 390
GLY A 249
ILE A 250
ILE A 378
ILE A 380
 None
 1.13A 6ebpD-4ru4A:
undetectable		 6ebpD-4ru4A:
10.77