SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ru5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 8 GLY A 441
ASN A 450
GLY A 440
VAL A 395
 None
 0.93A 1dbbH-4ru5A:
undetectable
1dbbL-4ru5A:
2.3		 1dbbH-4ru5A:
16.56
1dbbL-4ru5A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 11 LEU A 579
LEU A 581
ALA A 612
LEU A 625
MET A 597
 None
 1.05A 1g50A-4ru5A:
undetectable		 1g50A-4ru5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 9 ALA A 499
ASN A 532
SER A 504
ILE A 506
ILE A 529
 None
 1.50A 1j3jB-4ru5A:
undetectable		 1j3jB-4ru5A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 8 ARG A 497
TYR A 527
HIS A 421
TYR A 330
 None
 1.20A 1nx9A-4ru5A:
undetectable		 1nx9A-4ru5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 8 ARG A 497
TYR A 527
HIS A 421
TYR A 330
 None
 1.22A 1nx9B-4ru5A:
undetectable		 1nx9B-4ru5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 8 ARG A 497
TYR A 527
HIS A 421
TYR A 330
 None
 1.22A 1nx9C-4ru5A:
undetectable		 1nx9C-4ru5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 8 ARG A 497
TYR A 527
HIS A 421
TYR A 330
 None
 1.22A 1nx9D-4ru5A:
undetectable		 1nx9D-4ru5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 10 GLY A 368
VAL A 371
GLY A 370
VAL A 365
HIS A 421
 None
 1.24A 1pwyE-4ru5A:
undetectable		 1pwyE-4ru5A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 7 VAL A 389
VAL A 400
CYH A 486
CYH A 420
 None
 1.17A 1t46A-4ru5A:
undetectable		 1t46A-4ru5A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 HIS A 435
GLY A 491
PHE A 488
ASP A 473
TYR A 483
 None
 1.48A 1t69A-4ru5A:
undetectable		 1t69A-4ru5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 ALA A 430
ILE A 460
ILE A 415
VAL A 425
ILE A 481
 None
 1.14A 1xozA-4ru5A:
undetectable		 1xozA-4ru5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 LEU A 517
LEU A 559
GLY A 525
ARG A 497
LYS A 480
 None
 1.15A 1y4lA-4ru5A:
undetectable		 1y4lA-4ru5A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.27A 2pxcA-4ru5A:
undetectable		 2pxcA-4ru5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 SER A 511
GLY A 514
GLY A 519
THR A 520
VAL A 522
ILE A 548
 None
 1.39A 2wa2B-4ru5A:
undetectable		 2wa2B-4ru5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 10 ILE A 548
LEU A 494
GLY A 496
GLY A 524
GLN A 554
 None
 1.16A 2wd9C-4ru5A:
undetectable		 2wd9C-4ru5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 8 LEU A 610
LEU A 620
LYS A 644
ASN A 645
 None
 1.11A 2xn3A-4ru5A:
undetectable
2xn3B-4ru5A:
undetectable		 2xn3A-4ru5A:
19.74
2xn3B-4ru5A:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 ILE A 545
ILE A 546
GLY A 519
ALA A 516
LEU A 517
 None
 1.14A 2yvlA-4ru5A:
undetectable		 2yvlA-4ru5A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 ILE A 545
ILE A 546
GLY A 519
ALA A 516
LEU A 517
 None
 1.11A 2yvlB-4ru5A:
undetectable		 2yvlB-4ru5A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		3 / 3 GLY A 508
GLY A 538
GLY A 514
 None
 0.37A 3bogC-4ru5A:
undetectable		 3bogC-4ru5A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		3 / 3 GLY A 508
GLY A 538
GLY A 514
 None
 0.43A 3bogD-4ru5A:
undetectable		 3bogD-4ru5A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		3 / 3 ASP A 613
LEU A 620
GLN A 554
 None
 0.76A 3g4lA-4ru5A:
undetectable		 3g4lA-4ru5A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 LEU A 610
LEU A 579
LEU A 620
ASP A 614
ASP A 613
 None
 1.25A 3gwuA-4ru5A:
undetectable		 3gwuA-4ru5A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 GLY A 496
ASP A 479
GLY A 519
GLY A 525
ILE A 548
 None
 0.98A 3ku1G-4ru5A:
undetectable		 3ku1G-4ru5A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.26A 3p97A-4ru5A:
undetectable		 3p97A-4ru5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.21A 3p97C-4ru5A:
undetectable		 3p97C-4ru5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 VAL A 389
VAL A 400
VAL A 437
GLY A 414
LEU A 387
 None
 0.98A 3pghA-4ru5A:
undetectable		 3pghA-4ru5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 VAL A 389
VAL A 400
VAL A 437
GLY A 414
LEU A 387
 None
 1.00A 3pghC-4ru5A:
undetectable		 3pghC-4ru5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 6 VAL A 286
VAL A 320
ILE A 259
ARG A 451
 None
 0.99A 3pyyA-4ru5A:
undetectable		 3pyyA-4ru5A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 VAL A 389
VAL A 400
VAL A 437
GLY A 414
LEU A 387
 None
 1.03A 3rr3A-4ru5A:
undetectable		 3rr3A-4ru5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 VAL A 389
VAL A 400
VAL A 437
GLY A 414
LEU A 387
 None
 1.02A 3rr3B-4ru5A:
undetectable		 3rr3B-4ru5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 LEU A 387
ILE A 227
SER A 402
PRO A 354
VAL A 381
 None
 1.12A 3w1wA-4ru5A:
undetectable		 3w1wA-4ru5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.26A 4ctjA-4ru5A:
undetectable		 4ctjA-4ru5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.21A 4ctjC-4ru5A:
undetectable		 4ctjC-4ru5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.20A 4ctkC-4ru5A:
undetectable		 4ctkC-4ru5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 7 ASP A 380
SER A 353
HIS A 351
SER A 379
 None
 1.12A 4k7gB-4ru5A:
undetectable		 4k7gB-4ru5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 ASP A 628
HIS A 598
GLY A 629
GLY A 632
TYR A 678
 None
 1.11A 4lxzA-4ru5A:
undetectable		 4lxzA-4ru5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 ASP A 628
HIS A 598
GLY A 629
GLY A 632
TYR A 678
 None
 1.13A 4lxzC-4ru5A:
undetectable		 4lxzC-4ru5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 7 ILE A 546
LEU A 610
MET A 597
ALA A 562
ILE A 529
 None
 1.44A 4y03A-4ru5A:
undetectable		 4y03A-4ru5A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		3 / 3 VAL A 208
TYR A 197
ALA A 200
 None
 0.57A 4ybnA-4ru5A:
undetectable		 4ybnA-4ru5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 5 GLN A 655
ILE A 676
ILE A 718
TYR A 680
 None
 1.12A 5dnuA-4ru5A:
undetectable		 5dnuA-4ru5A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 5 GLN A 655
ILE A 676
ILE A 718
TYR A 680
 None
 1.07A 5dnvA-4ru5A:
undetectable		 5dnvA-4ru5A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.21A 5ec8C-4ru5A:
undetectable		 5ec8C-4ru5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.26A 5eifA-4ru5A:
undetectable		 5eifA-4ru5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.21A 5eifC-4ru5A:
undetectable		 5eifC-4ru5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.22A 5eiwC-4ru5A:
undetectable		 5eiwC-4ru5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.23A 5ekxB-4ru5A:
undetectable		 5ekxB-4ru5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 6 TYR A 384
ASP A 473
ILE A 417
TYR A 304
 None
 1.30A 5igyA-4ru5A:
undetectable		 5igyA-4ru5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 6 TYR A 304
ASP A 473
HIS A 475
ILE A 481
 None
 1.27A 5ih0A-4ru5A:
undetectable		 5ih0A-4ru5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		5 / 12 VAL A 389
VAL A 400
VAL A 437
GLY A 414
LEU A 387
 None
 1.08A 5iktA-4ru5A:
undetectable		 5iktA-4ru5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 8 GLN A 689
ALA A 735
SER A 692
HIS A 738
 None
 1.06A 5km8A-4ru5A:
undetectable
5km8B-4ru5A:
undetectable		 5km8A-4ru5A:
12.63
5km8B-4ru5A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.27A 5kqsA-4ru5A:
undetectable		 5kqsA-4ru5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		6 / 12 GLY A 491
GLY A 519
GLY A 470
THR A 520
VAL A 522
ILE A 548
 None
 1.26A 5njvB-4ru5A:
undetectable		 5njvB-4ru5A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		3 / 3 HIS A 475
ASP A 473
HIS A 435
 None
 0.70A 5oexA-4ru5A:
undetectable		 5oexA-4ru5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		3 / 3 HIS A 475
ASP A 473
HIS A 435
 None
 0.72A 5oexB-4ru5A:
undetectable		 5oexB-4ru5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		3 / 3 HIS A 475
ASP A 473
HIS A 435
 None
 0.76A 5oexC-4ru5A:
undetectable		 5oexC-4ru5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		3 / 3 HIS A 475
ASP A 473
HIS A 435
 None
 0.74A 5oexD-4ru5A:
undetectable		 5oexD-4ru5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 4 VAL A 373
VAL A 347
TYR A 376
GLN A 349
 None
 1.50A 5qggA-4ru5A:
undetectable		 5qggA-4ru5A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 4 VAL A 373
VAL A 347
TYR A 376
GLN A 349
 None
 1.46A 5qgqA-4ru5A:
undetectable		 5qgqA-4ru5A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 4 VAL A 373
VAL A 347
TYR A 376
GLN A 349
 None
 1.49A 5qhbA-4ru5A:
undetectable		 5qhbA-4ru5A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		3 / 3 TYR A 384
ALA A 438
TYR A 413
 None
 0.78A 5uunB-4ru5A:
undetectable		 5uunB-4ru5A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		4 / 4 ASP A 380
SER A 353
ASP A 239
HIS A 214
 None
 1.19A 5wyqB-4ru5A:
undetectable		 5wyqB-4ru5A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4ru5 TAILSPIKE GP27
(Pseudomonas
phage
phi297) 		3 / 3 TYR A 304
HIS A 475
MET A 474
 None
 1.10A 6af6A-4ru5A:
undetectable		 6af6A-4ru5A:
21.42