SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ruh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A  98
LEU A 162
PHE A 424
LEU A  85
VAL A  52
 None
 1.13A 1fduA-4ruhA:
2.4		 1fduA-4ruhA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 SER A 359
PHE A 216
GLU A 355
GLY A 354
 None
 1.15A 1icuA-4ruhA:
2.2
1icuB-4ruhA:
undetectable		 1icuA-4ruhA:
18.70
1icuB-4ruhA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 SER A 359
PHE A 216
GLU A 355
GLY A 354
 None
 1.14A 1kqbC-4ruhA:
undetectable
1kqbD-4ruhA:
undetectable		 1kqbC-4ruhA:
17.93
1kqbD-4ruhA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 PHE A 216
GLU A 355
GLY A 354
SER A 359
 None
 1.16A 1kqbC-4ruhA:
undetectable
1kqbD-4ruhA:
undetectable		 1kqbC-4ruhA:
17.93
1kqbD-4ruhA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 10 LEU A 118
GLY A 135
ASP A 133
ASP A 132
GLY A 438
 None
None
MN  A 502 ( 4.8A)
MN  A 503 (-2.4A)
None
 0.98A 1t7iA-4ruhA:
undetectable		 1t7iA-4ruhA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A 129
SER A 130
GLY A 135
VAL A  31
ILE A  41
 None
 1.15A 2b25B-4ruhA:
undetectable		 2b25B-4ruhA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 11 VAL A 353
GLY A 354
LEU A 344
ARG A 343
SER A 417
 None
None
None
BES  A 501 (-2.5A)
BES  A 501 (-4.4A)
 1.24A 2bxgA-4ruhA:
undetectable		 2bxgA-4ruhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 8 LEU A 199
LEU A 305
ASP A 283
ARG A 308
 None
 1.08A 2j2pA-4ruhA:
undetectable
2j2pB-4ruhA:
undetectable		 2j2pA-4ruhA:
19.87
2j2pB-4ruhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 7 VAL A 404
THR A 403
PHE A 405
LYS A 203
 None
 1.22A 2kotA-4ruhA:
undetectable		 2kotA-4ruhA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 118
GLY A 135
ASP A 133
ASP A 132
GLY A 438
 None
None
MN  A 502 ( 4.8A)
MN  A 503 (-2.4A)
None
 1.01A 3cyxA-4ruhA:
undetectable		 3cyxA-4ruhA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 11 SER A 471
ALA A 143
ILE A 154
VAL A 158
VAL A 156
 None
 0.94A 3kw4A-4ruhA:
undetectable		 3kw4A-4ruhA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 10 LEU A 118
GLY A 135
ASP A 133
ASP A 132
GLY A 438
 None
None
MN  A 502 ( 4.8A)
MN  A 503 (-2.4A)
None
 1.05A 3oxwA-4ruhA:
undetectable		 3oxwA-4ruhA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A 123
ASN A 452
LEU A 451
THR A 117
LEU A 118
 None
 1.12A 3p2kB-4ruhA:
undetectable		 3p2kB-4ruhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 118
GLY A 135
ASP A 133
ASP A 132
GLY A 438
 None
None
MN  A 502 ( 4.8A)
MN  A 503 (-2.4A)
None
 1.01A 3pwrA-4ruhA:
undetectable		 3pwrA-4ruhA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 6 ILE A 457
ILE A 206
MET A 462
TRP A 140
 None
 1.26A 3welA-4ruhA:
undetectable		 3welA-4ruhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 7 LEU A 473
ASP A 475
TYR A 466
HIS A 393
 None
 1.18A 4arcA-4ruhA:
undetectable		 4arcA-4ruhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 9 LEU A 118
GLY A 135
ASP A 133
ASP A 132
GLY A 438
 None
None
MN  A 502 ( 4.8A)
MN  A 503 (-2.4A)
None
 1.07A 4dqcB-4ruhA:
undetectable		 4dqcB-4ruhA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 7 ASP A 132
GLU A 167
HIS A 445
GLU A 166
 MN  A 503 (-2.4A)
MN  A 503 (-1.9A)
MN  A 503 ( 3.3A)
BES  A 501 (-2.9A)
 1.09A 4hvrA-4ruhA:
undetectable		 4hvrA-4ruhA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 5 ASN A 455
GLY A 438
ASP A 112
ASP A 441
 None
 1.15A 4n48B-4ruhA:
undetectable		 4n48B-4ruhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 4 ASN A 455
GLY A 438
ASP A 112
ASP A 441
 None
 1.11A 4n49A-4ruhA:
undetectable		 4n49A-4ruhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 10 LEU A 118
GLY A 135
ASP A 133
ASP A 132
GLY A 438
 None
None
MN  A 502 ( 4.8A)
MN  A 503 (-2.4A)
None
 1.00A 4njtB-4ruhA:
undetectable		 4njtB-4ruhA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		7 / 11 HIS A  99
ASP A 132
GLU A 166
GLU A 167
GLY A 415
GLY A 416
HIS A 445
 MN  A 502 ( 3.6A)
MN  A 503 (-2.4A)
BES  A 501 (-2.9A)
MN  A 503 (-1.9A)
None
BES  A 501 (-3.6A)
MN  A 503 ( 3.3A)
 0.64A 4pqaA-4ruhA:
33.6		 4pqaA-4ruhA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 9 LEU A 118
GLY A 135
ASP A 133
ASP A 132
GLY A 438
 None
None
MN  A 502 ( 4.8A)
MN  A 503 (-2.4A)
None
 0.98A 4q1wA-4ruhA:
undetectable		 4q1wA-4ruhA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 451
VAL A 437
PRO A 136
SER A  30
GLY A 164
 None
 1.37A 5f9zB-4ruhA:
undetectable		 5f9zB-4ruhA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		3 / 3 ARG A 159
ILE A  96
PHE A 160
 None
 0.68A 5kirA-4ruhA:
undetectable		 5kirA-4ruhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 451
VAL A 437
PRO A 136
SER A  30
GLY A 164
 None
 1.32A 6mn8A-4ruhA:
undetectable		 6mn8A-4ruhA:
21.35