SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 8 ILE A 491
MET A 546
VAL A 175
GLY A 492
 None
 1.00A 1dzmA-4rulA:
undetectable		 1dzmA-4rulA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 4 ILE A 491
MET A 546
VAL A 175
GLY A 492
 None
 1.04A 1e06B-4rulA:
undetectable		 1e06B-4rulA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 8 ARG A 173
GLY A  72
TRP A  79
PHE A 571
 SO4  A1005 (-3.1A)
None
None
None
 1.00A 1fapB-4rulA:
undetectable		 1fapB-4rulA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 8 THR A 667
GLY A 684
CYH A 683
THR A 688
 None
None
ZN  A1002 (-2.3A)
None
 0.88A 1h4oB-4rulA:
undetectable		 1h4oB-4rulA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 11 MET A 546
SER A 549
ALA A 562
LEU A 564
ALA A 167
 None
 1.41A 1jb0B-4rulA:
undetectable		 1jb0B-4rulA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 8 THR A 667
GLY A 684
CYH A 683
THR A 688
 None
None
ZN  A1002 (-2.3A)
None
 0.88A 1oc3A-4rulA:
undetectable		 1oc3A-4rulA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 6 ASN A 548
ARG A 168
ILE A 491
GLY A 492
 None
 1.03A 1oniA-4rulA:
undetectable
1oniB-4rulA:
undetectable		 1oniA-4rulA:
10.45
1oniB-4rulA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 6 ASN A 548
ARG A 168
ILE A 491
GLY A 492
 None
 1.04A 1oniD-4rulA:
undetectable
1oniF-4rulA:
undetectable		 1oniD-4rulA:
10.45
1oniF-4rulA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 7 ILE A 491
GLY A 492
ASN A 548
ARG A 168
 None
 0.95A 1oniG-4rulA:
undetectable
1oniI-4rulA:
undetectable		 1oniG-4rulA:
10.45
1oniI-4rulA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		6 / 12 VAL A   8
ILE A 142
ILE A 147
PHE A 139
VAL A  27
LEU A  21
 None
 1.24A 1qhsA-4rulA:
undetectable		 1qhsA-4rulA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		3 / 3 TRP A  79
PHE A 568
TRP A  76
 None
 1.39A 1r15C-4rulA:
undetectable		 1r15C-4rulA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		3 / 3 TRP A  79
PHE A 568
TRP A  76
 None
 1.38A 1r15F-4rulA:
undetectable		 1r15F-4rulA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		3 / 3 TRP A  79
PHE A 568
TRP A  76
 None
 1.39A 1r15G-4rulA:
undetectable		 1r15G-4rulA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		3 / 3 TRP A  79
PHE A 568
TRP A  76
 None
 1.37A 1r15H-4rulA:
undetectable		 1r15H-4rulA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 12 VAL A 268
LEU A 413
VAL A 415
LEU A 234
THR A 226
 None
 0.66A 2aw1A-4rulA:
undetectable		 2aw1A-4rulA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 8 VAL A 268
VAL A 415
LEU A 234
THR A 226
 None
 0.74A 2gehA-4rulA:
undetectable		 2gehA-4rulA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		3 / 3 LEU A 594
MET A 592
MET A 669
 None
 0.90A 2vavF-4rulA:
undetectable		 2vavF-4rulA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 12 SER A  29
VAL A   8
PHE A 151
ILE A  17
ASN A  18
 None
 1.42A 2vdyB-4rulA:
undetectable		 2vdyB-4rulA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		3 / 3 ARG A 207
ARG A 476
PRO A 474
 None
 1.10A 2wljA-4rulA:
undetectable		 2wljA-4rulA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 6 LEU A 234
THR A 226
ARG A 271
LEU A 422
 None
 0.92A 2wm3A-4rulA:
undetectable		 2wm3A-4rulA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 8 LEU A 564
ARG A 169
GLY A 176
MET A 178
 None
SO4  A1005 (-2.7A)
None
None
 1.15A 3hcrA-4rulA:
2.7		 3hcrA-4rulA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 7 LEU A 564
ARG A 169
GLY A 176
MET A 178
 None
SO4  A1005 (-2.7A)
None
None
 1.05A 3hcrB-4rulA:
2.7		 3hcrB-4rulA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 11 MET A 546
SER A 549
ALA A 562
LEU A 564
ALA A 167
 None
 1.40A 3pcqB-4rulA:
undetectable		 3pcqB-4rulA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 10 TYR A 312
ILE A 317
ASN A 140
ILE A 368
ALA A 308
 None
 1.31A 3u6tA-4rulA:
undetectable		 3u6tA-4rulA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 5 SER A 499
GLU A 115
THR A 496
ASP A 113
 None
 1.42A 3zs3A-4rulA:
undetectable		 3zs3A-4rulA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 8 ASN A 514
LYS A 472
ASN A 654
THR A 653
 None
 1.17A 4d1yA-4rulA:
undetectable
4d1yB-4rulA:
undetectable		 4d1yA-4rulA:
12.00
4d1yB-4rulA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 10 VAL A 268
LEU A 413
VAL A 415
LEU A 234
THR A 226
 None
 0.75A 4e3hA-4rulA:
undetectable		 4e3hA-4rulA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 12 VAL A 268
LEU A 413
VAL A 415
LEU A 234
THR A 226
 None
 0.69A 4k13A-4rulA:
undetectable		 4k13A-4rulA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 12 VAL A 268
LEU A 413
VAL A 415
LEU A 234
THR A 226
 None
 0.68A 4m2wA-4rulA:
undetectable		 4m2wA-4rulA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 12 LEU A 182
ALA A 193
MET A 538
SER A 198
MET A 587
 None
 1.41A 4udaA-4rulA:
undetectable		 4udaA-4rulA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_G_AZMG402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 12 VAL A 268
LEU A 413
VAL A 415
LEU A 234
THR A 226
 None
 0.68A 4xiwG-4rulA:
undetectable		 4xiwG-4rulA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 4 GLY A 315
LEU A 289
PHE A 284
ILE A 394
 None
 0.99A 4xv2A-4rulA:
undetectable		 4xv2A-4rulA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		3 / 3 ARG A 493
ASN A 548
ASP A 541
 None
 0.85A 5gwxA-4rulA:
undetectable		 5gwxA-4rulA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 12 ASN A 326
GLN A 402
THR A 288
GLY A 281
GLN A 354
 None
 1.26A 5oj0A-4rulA:
undetectable		 5oj0A-4rulA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		4 / 8 VAL A 268
VAL A 415
LEU A 234
THR A 226
 None
 0.63A 5tt3F-4rulA:
undetectable		 5tt3F-4rulA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4rul DNA TOPOISOMERASE 1
(Escherichia
coli) 		5 / 11 ILE A 394
ALA A 400
GLY A 281
PHE A 284
ALA A 292
 None
 1.15A 6ieyA-4rulA:
undetectable
6ieyB-4rulA:
undetectable		 6ieyA-4rulA:
17.94
6ieyB-4rulA:
17.94