SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4run'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4run ODORANT-BINDING
PROTEIN 2A
(Homo
sapiens) 		3 / 3 ALA A  41
VAL A  39
TRP A  14
 None
 0.88A 1tkqB-4runA:
undetectable		 1tkqB-4runA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 4run ODORANT-BINDING
PROTEIN 2A
(Homo
sapiens) 		5 / 12 GLU A   8
TYR A  95
THR A  92
LEU A  89
LEU A 131
 None
 1.42A 2mjiA-4runA:
undetectable		 2mjiA-4runA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4run ODORANT-BINDING
PROTEIN 2A
(Homo
sapiens) 		5 / 12 LEU A 113
ALA A 124
GLU A 127
PHE A 128
LEU A 131
 None
 0.87A 4i1rA-4runA:
undetectable		 4i1rA-4runA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4run ODORANT-BINDING
PROTEIN 2A
(Homo
sapiens) 		4 / 4 LYS A 130
LEU A 131
GLU A 127
LEU A  89
 None
 1.41A 4k4yE-4runA:
undetectable		 4k4yE-4runA:
17.80