SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ruw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		3 / 3 ALA A 195
VAL A 181
TRP A 124
 None
 0.93A 1av2A-4ruwA:
undetectable
1av2B-4ruwA:
undetectable		 1av2A-4ruwA:
3.08
1av2B-4ruwA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		3 / 3 TRP A 124
ALA A 195
VAL A 181
 None
 0.85A 1av2C-4ruwA:
undetectable
1av2D-4ruwA:
undetectable		 1av2C-4ruwA:
3.08
1av2D-4ruwA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 7 GLY A 141
PRO A 140
SER A 142
ALA A 137
 None
 0.99A 1gxsA-4ruwA:
undetectable
1gxsB-4ruwA:
undetectable		 1gxsA-4ruwA:
19.78
1gxsB-4ruwA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 12 HIS A 104
GLY A 105
HIS A 134
LEU A 139
PRO A 140
 ZN  A 501 (-3.1A)
None
ZN  A 501 (-3.2A)
None
None
 1.27A 1mj2C-4ruwA:
undetectable
1mj2D-4ruwA:
undetectable		 1mj2C-4ruwA:
11.71
1mj2D-4ruwA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 12 HIS A 104
GLY A 105
HIS A 134
LEU A 139
PRO A 140
 ZN  A 501 (-3.1A)
None
ZN  A 501 (-3.2A)
None
None
 1.27A 1mjoC-4ruwA:
undetectable
1mjoD-4ruwA:
undetectable		 1mjoC-4ruwA:
11.71
1mjoD-4ruwA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		3 / 3 ALA A 195
VAL A 181
TRP A 124
 None
 0.95A 1w5uA-4ruwA:
undetectable
1w5uB-4ruwA:
undetectable		 1w5uA-4ruwA:
3.08
1w5uB-4ruwA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 4 SER A 361
ASP A 302
ARG A 326
ASP A  52
 None
 1.20A 2bm9C-4ruwA:
undetectable		 2bm9C-4ruwA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 11 LEU A 435
LEU A 380
SER A 361
LEU A 360
LEU A 416
 None
 1.11A 2ceoA-4ruwA:
undetectable		 2ceoA-4ruwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 6 HIS A 318
ASN A 234
THR A 275
PRO A 274
 None
None
None
GOL  A 502 ( 4.6A)
 1.49A 2ez7A-4ruwA:
undetectable		 2ez7A-4ruwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 5 VAL A 191
VAL A  55
ASP A  87
SER A 150
 None
 1.28A 2x45A-4ruwA:
undetectable		 2x45A-4ruwA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 12 GLY A 273
GLY A 271
ASP A 269
LEU A 319
TYR A 294
 None
None
GOL  A 503 (-3.0A)
None
None
 1.17A 2zw9B-4ruwA:
undetectable		 2zw9B-4ruwA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 5 GLN A 213
THR A 180
HIS A 194
LEU A 229
 None
 1.36A 3ce6A-4ruwA:
undetectable		 3ce6A-4ruwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 7 LEU A 435
LEU A 350
SER A 353
THR A 405
 None
 1.00A 3lm8A-4ruwA:
undetectable
3lm8C-4ruwA:
undetectable		 3lm8A-4ruwA:
16.52
3lm8C-4ruwA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 6 THR A 238
ASN A 365
GLY A 346
ASP A 345
 None
 1.31A 3w9tE-4ruwA:
undetectable		 3w9tE-4ruwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 12 VAL A 225
VAL A 183
LEU A 179
VAL A 159
VAL A 228
 None
 1.09A 4ib4A-4ruwA:
undetectable		 4ib4A-4ruwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 8 LEU A 325
THR A  57
LEU A  53
VAL A  90
 None
 0.98A 4ik6B-4ruwA:
undetectable		 4ik6B-4ruwA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 12 VAL A 376
ASP A 372
SER A 397
ARG A 265
THR A 374
 None
 1.47A 4kyaB-4ruwA:
undetectable		 4kyaB-4ruwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 12 VAL A 376
ASP A 372
SER A 397
ARG A 265
THR A 374
 None
 1.44A 4kyaD-4ruwA:
undetectable		 4kyaD-4ruwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 12 VAL A 376
ASP A 372
SER A 397
ARG A 265
THR A 374
 None
 1.43A 4kyaH-4ruwA:
undetectable		 4kyaH-4ruwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 11 THR A 128
SER A 143
GLN A 107
GLY A 126
ASP A 106
 None
 1.49A 4qvnH-4ruwA:
undetectable
4qvnI-4ruwA:
undetectable		 4qvnH-4ruwA:
20.40
4qvnI-4ruwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 10 THR A 128
SER A 143
GLN A 107
GLY A 126
ASP A 106
 None
 1.48A 4qvnV-4ruwA:
undetectable
4qvnW-4ruwA:
undetectable		 4qvnV-4ruwA:
20.40
4qvnW-4ruwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 11 THR A 128
SER A 143
GLN A 107
GLY A 126
ASP A 106
 None
 1.48A 4qvqH-4ruwA:
undetectable
4qvqI-4ruwA:
undetectable		 4qvqH-4ruwA:
20.40
4qvqI-4ruwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 11 THR A 128
SER A 143
GLN A 107
GLY A 126
ASP A 106
 None
 1.47A 4qvqV-4ruwA:
undetectable
4qvqW-4ruwA:
undetectable		 4qvqV-4ruwA:
20.40
4qvqW-4ruwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 5 SER A 199
ARG A 175
LEU A 206
ASP A 209
 None
 1.47A 4xdtA-4ruwA:
undetectable		 4xdtA-4ruwA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 6 ILE A 235
VAL A 217
PHE A 296
ARG A 265
 None
 1.12A 4xe5A-4ruwA:
undetectable		 4xe5A-4ruwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 9 THR A 275
LEU A 233
GLY A 231
THR A  57
VAL A 321
 None
 1.28A 5cp4A-4ruwA:
undetectable		 5cp4A-4ruwA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 12 HIS A 197
ASP A 232
ASN A 234
ILE A 292
HIS A 318
 None
 0.20A 5dv4A-4ruwA:
23.9		 5dv4A-4ruwA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 6 HIS A 194
LEU A 178
HIS A 220
LEU A 218
 None
 1.14A 5hrqD-4ruwA:
undetectable
5hrqG-4ruwA:
undetectable
5hrqH-4ruwA:
undetectable		 5hrqD-4ruwA:
4.90
5hrqG-4ruwA:
3.26
5hrqH-4ruwA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		4 / 8 LEU A  91
ALA A  79
VAL A 147
GLN A 107
 None
 0.98A 5nu7A-4ruwA:
undetectable		 5nu7A-4ruwA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
(Beutenbergia
cavernae) 		5 / 9 PHE A 154
GLY A 156
VAL A 181
GLY A 158
LEU A 179
 None
 1.41A 5wm2A-4ruwA:
undetectable		 5wm2A-4ruwA:
10.55