SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4rv0 NUCLEAR PROTEIN
LOCALIZATION PROTEIN
4 HOMOLOG
(Drosophila
melanogaster) 		4 / 8 TYR B  31
GLU B  54
PHE B  46
VAL B  34
 None
 0.98A 2fl5E-4rv0B:
undetectable
2fl5F-4rv0B:
undetectable		 2fl5E-4rv0B:
16.19
2fl5F-4rv0B:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94
(Drosophila
melanogaster) 		3 / 3 SER A  70
ASP A  76
ASP A  44
 None
 0.81A 2plwA-4rv0A:
undetectable		 2plwA-4rv0A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94
(Drosophila
melanogaster) 		4 / 5 VAL A  84
VAL A  85
PHE A 160
ARG A  60
 None
 1.36A 3bjwH-4rv0A:
undetectable		 3bjwH-4rv0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 4rv0 NUCLEAR PROTEIN
LOCALIZATION PROTEIN
4 HOMOLOG
(Drosophila
melanogaster) 		5 / 11 LEU B  62
GLY B  64
ILE B   6
LYS B   5
PRO B  23
 None
 1.37A 3bjwE-4rv0B:
undetectable		 3bjwE-4rv0B:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94
(Drosophila
melanogaster) 		4 / 5 VAL A  84
VAL A  85
PHE A 160
ARG A  60
 None
 1.28A 3bjwB-4rv0A:
undetectable		 3bjwB-4rv0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94
(Drosophila
melanogaster) 		4 / 5 ARG A 141
ILE A  67
VAL A 105
THR A 177
 None
 1.25A 3eigA-4rv0A:
undetectable		 3eigA-4rv0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94
(Drosophila
melanogaster) 		4 / 7 ILE A 113
PHE A 136
ASP A 147
THR A  64
 None
 1.11A 4mmcA-4rv0A:
undetectable		 4mmcA-4rv0A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94
(Drosophila
melanogaster) 		5 / 9 LEU A  48
THR A  64
VAL A  85
VAL A  36
LEU A  89
 None
 1.28A 4wnvA-4rv0A:
undetectable		 4wnvA-4rv0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94
(Drosophila
melanogaster) 		5 / 12 GLY A  16
VAL A  54
LEU A  48
VAL A  36
ILE A  79
 None
 1.00A 5vopA-4rv0A:
undetectable		 5vopA-4rv0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94
(Drosophila
melanogaster) 		4 / 6 ARG A  80
ARG A  86
ASP A  71
ASP A  31
 None
SO4  A 201 (-3.5A)
None
None
 1.15A 5zw4A-4rv0A:
undetectable		 5zw4A-4rv0A:
21.15