SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 PHE A  59
THR A  58
ILE A  62
HIS A  28
 None
 0.96A 1ei6C-4rv2A:
undetectable		 1ei6C-4rv2A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 PHE A  59
THR A  58
ILE A  62
HIS A  28
 None
 0.95A 1ei6D-4rv2A:
undetectable		 1ei6D-4rv2A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.88A 1p7lD-4rv2A:
undetectable		 1p7lD-4rv2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.89A 1p7lC-4rv2A:
undetectable		 1p7lC-4rv2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.89A 1rg9B-4rv2A:
undetectable		 1rg9B-4rv2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.88A 1rg9A-4rv2A:
undetectable		 1rg9A-4rv2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.88A 1rg9D-4rv2A:
undetectable		 1rg9D-4rv2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.89A 1rg9C-4rv2A:
undetectable		 1rg9C-4rv2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4rv2 MAOC FAMILY PROTEIN
UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 7 HIS A  28
GLN A 136
PHE A  93
VAL B  80
 None
 1.15A 3jwqC-4rv2A:
undetectable		 3jwqC-4rv2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 7 PHE A  59
THR A  58
ILE A  62
HIS A  28
 None
 0.87A 3t01A-4rv2A:
undetectable		 3t01A-4rv2A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4rv2 MAOC FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY B  67
GLY B  64
LEU B  61
ALA B 137
PHE B 104
 None
 1.10A 3vywD-4rv2B:
undetectable		 3vywD-4rv2B:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.85A 4ndnB-4rv2A:
undetectable		 4ndnB-4rv2A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.95A 4ndnD-4rv2A:
undetectable		 4ndnD-4rv2A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 4rv2 MAOC FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY B  59
ALA B  57
LEU B  65
ASN B  29
SER B  34
 SO4  B 201 (-3.5A)
None
None
None
None
 1.25A 4pb1A-4rv2B:
undetectable		 4pb1A-4rv2B:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rv2 MAOC FAMILY PROTEIN
UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 7 PHE B 104
ILE B  20
GLY B  67
THR A  58
 None
 0.92A 4zdzA-4rv2B:
undetectable		 4zdzA-4rv2B:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rv2 MAOC FAMILY PROTEIN
UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU B  52
PHE B 104
ILE B  20
GLY B  67
THR A  58
 None
 1.01A 5eshA-4rv2B:
undetectable		 5eshA-4rv2B:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rv2 MAOC FAMILY PROTEIN
UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 7 PHE B 104
ILE B  20
GLY B  67
THR A  58
 None
 0.93A 5esmA-4rv2B:
undetectable		 5esmA-4rv2B:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
MAOC FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis;
Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY B  67
PRO A  54
THR B  71
THR A  58
 None
 1.19A 5h5fA-4rv2B:
undetectable		 5h5fA-4rv2B:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rv2 MAOC FAMILY PROTEIN
UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		6 / 12 PHE B 104
ILE B  20
PHE B 132
GLY B  67
THR A  58
THR A 141
 None
 1.23A 5jlcA-4rv2B:
undetectable		 5jlcA-4rv2B:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.91A 5t8sA-4rv2A:
undetectable		 5t8sA-4rv2A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.93A 6fbnA-4rv2A:
undetectable		 6fbnA-4rv2A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rv2 MAOC FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 TYR B  83
VAL B  11
PHE B 104
GLY B  68
 None
 1.37A 6hd4A-4rv2B:
undetectable		 6hd4A-4rv2B:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4rv2 MAOC FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN B  38
GLN B  49
PRO B  39
ILE B  40
 None
 0.93A 6hzpA-4rv2B:
undetectable		 6hzpA-4rv2B:
17.19