SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 12 GLY A 145
HIS A  61
LEU A  57
ALA A 167
PHE A 150
 None
 1.05A 1eqbA-4rv4A:
undetectable		 1eqbA-4rv4A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 12 GLY A 145
HIS A  61
LEU A  57
ALA A 167
PHE A 150
 None
 1.06A 1eqbB-4rv4A:
undetectable		 1eqbB-4rv4A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 12 GLY A 145
HIS A  61
LEU A  57
ALA A 167
PHE A 150
 None
 1.05A 1eqbC-4rv4A:
undetectable		 1eqbC-4rv4A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 12 GLY A 145
HIS A  61
LEU A  57
ALA A 167
PHE A 150
 None
 1.05A 1eqbD-4rv4A:
undetectable		 1eqbD-4rv4A:
19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 8 ALA A  74
GLY A  75
THR A  71
ARG A  38
GLU A 120
 PRP  A 301 (-3.3A)
None
PRP  A 301 ( 4.7A)
PRP  A 301 (-3.7A)
PRP  A 301 (-2.9A)
 1.21A 3rglA-4rv4A:
undetectable		 3rglA-4rv4A:
30.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 12 ALA A  74
HIS A  78
GLY A  70
LYS A 105
ALA A 135
 PRP  A 301 (-3.3A)
None
None
None
None
 1.17A 3tm4A-4rv4A:
undetectable		 3tm4A-4rv4A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 12 ALA A  74
HIS A  78
GLY A  70
LYS A 105
ALA A 135
 PRP  A 301 (-3.3A)
None
None
None
None
 1.12A 3tm4B-4rv4A:
undetectable		 3tm4B-4rv4A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		4 / 6 ALA A 129
GLY A 157
SER A 170
ILE A 146
 None
 0.72A 4r21A-4rv4A:
undetectable		 4r21A-4rv4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
anthracis) 		5 / 12 LEU A 136
VAL A 166
LYS A 160
ALA A 164
ILE A 146
 None
 1.19A 4x1kD-4rv4A:
undetectable		 4x1kD-4rv4A:
18.18