SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 12 LEU A  12
SER A  33
ILE A  32
LEU A  59
ILE A  81
 HEZ  A1003 ( 4.9A)
None
None
None
None
 0.88A 1dhiA-4rv7A:
undetectable		 1dhiA-4rv7A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 12 LEU A  12
SER A  33
ILE A  32
LEU A  59
ILE A  81
 HEZ  A1003 ( 4.9A)
None
None
None
None
 0.88A 1dhjA-4rv7A:
undetectable		 1dhjA-4rv7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 12 ILE A  54
ALA A  82
GLN A   9
ILE A 117
LEU A 153
 None
None
HEZ  A1003 (-4.2A)
None
HEZ  A1003 (-4.9A)
 1.21A 1dlsA-4rv7A:
undetectable		 1dlsA-4rv7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 12 LEU A  12
SER A  33
ILE A  32
LEU A  59
ILE A  81
 HEZ  A1003 ( 4.9A)
None
None
None
None
 0.86A 1draA-4rv7A:
undetectable		 1draA-4rv7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 12 LEU A  12
SER A  33
ILE A  32
LEU A  59
ILE A  81
 HEZ  A1003 ( 4.9A)
None
None
None
None
 0.88A 1drbA-4rv7A:
undetectable		 1drbA-4rv7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 12 LEU A  12
SER A  33
ILE A  32
LEU A  59
ILE A  81
 HEZ  A1003 ( 4.9A)
None
None
None
None
 0.86A 2drcA-4rv7A:
undetectable		 2drcA-4rv7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 11 LEU A  58
ILE A  44
GLY A  47
ALA A  52
ILE A  81
 None
 0.92A 2idwA-4rv7A:
undetectable		 2idwA-4rv7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		4 / 6 ARG A 103
PHE A  63
PRO A  65
THR A  67
 ATP  A1001 (-3.5A)
None
None
None
 1.35A 2m2oB-4rv7A:
undetectable		 2m2oB-4rv7A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 12 ILE A  32
ILE A 128
SER A 129
LEU A 149
ILE A  16
 None
 1.18A 3cd2A-4rv7A:
undetectable		 3cd2A-4rv7A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 12 LEU A  12
SER A  33
ILE A  32
LEU A  59
ILE A  81
 HEZ  A1003 ( 4.9A)
None
None
None
None
 0.86A 3drcA-4rv7A:
undetectable		 3drcA-4rv7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 9 LEU A  50
ILE A  16
ILE A  60
ALA A  84
ILE A  81
 None
 1.02A 3el0B-4rv7A:
undetectable		 3el0B-4rv7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 9 LEU A  58
ILE A  44
GLY A  47
ALA A  52
ILE A  81
 None
 1.04A 3el0B-4rv7A:
undetectable		 3el0B-4rv7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 10 ILE A  44
SER A 129
ARG A 103
ALA A  30
ALA A 107
 None
None
ATP  A1001 (-3.5A)
None
None
 1.39A 3lw5B-4rv7A:
undetectable		 3lw5B-4rv7A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 11 ASP A  41
VAL A 113
ILE A 110
LYS A  77
ILE A  75
 None
 1.28A 3o5rA-4rv7A:
undetectable		 3o5rA-4rv7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 10 ASP A  41
VAL A 113
ILE A 110
LYS A  77
ILE A  75
 None
 1.41A 4laxA-4rv7A:
undetectable		 4laxA-4rv7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 10 ASP A  41
VAL A 113
ILE A 110
LYS A  77
ILE A  75
 None
 1.42A 4nnrB-4rv7A:
undetectable		 4nnrB-4rv7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4rv7 DIADENYLATE CYCLASE
(Listeria
monocytogenes) 		5 / 12 ILE A  32
PHE A  63
GLY A  72
ALA A  85
ILE A  81
 None
None
ATP  A1001 (-3.3A)
None
None
 1.10A 6dwnD-4rv7A:
undetectable		 6dwnD-4rv7A:
19.46