SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 8 ILE A 322
LEU A 345
LYS A 330
GLY A 331
None
None
3YN  A 503 (-2.9A)
None
1.07A 1os6A-4rvhA:
undetectable
1os6A-4rvhA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 10 PHE A 203
SER A 201
LEU A 196
PHE A 156
VAL A 174
None
1.47A 1q23E-4rvhA:
undetectable
1q23E-4rvhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 11 VAL A 312
ILE A 322
LEU A 345
LEU A 334
LEU A 335
None
1.19A 2a15A-4rvhA:
undetectable
2a15A-4rvhA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
3 / 3 SER A 234
HIS A 226
ASP A 220
None
3YN  A 503 (-4.5A)
None
0.76A 2oxtA-4rvhA:
6.8
2oxtA-4rvhA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 7 TRP A  21
SER A 234
CYH A  59
SER A 228
None
None
ZN  A 501 (-2.3A)
None
1.28A 2xz5A-4rvhA:
undetectable
2xz5B-4rvhA:
undetectable
2xz5A-4rvhA:
18.47
2xz5B-4rvhA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 5 ALA A 373
GLN A 376
ILE A 378
ARG A 321
CSO  A 349 ( 3.9A)
None
None
None
1.26A 2z0aA-4rvhA:
undetectable
2z0aA-4rvhA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 4 GLU A 112
GLY A 133
THR A 151
GLU A 150
None
1.00A 3e9xA-4rvhA:
1.5
3e9xA-4rvhA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 12 ILE A 113
GLY A 114
PRO A 136
ALA A 137
PHE A 156
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.0A)
SAH  A 502 ( 3.8A)
None
0.70A 3jayA-4rvhA:
undetectable
3jayA-4rvhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
6 / 12 ILE A 113
GLY A 114
ASP A 135
PRO A 136
ALA A 137
PHE A 156
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-2.7A)
SAH  A 502 (-4.0A)
SAH  A 502 ( 3.8A)
None
0.67A 3jb1A-4rvhA:
8.7
3jb1A-4rvhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
6 / 12 ILE A 113
GLY A 114
PRO A 136
ALA A 137
PHE A 156
VAL A 179
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.0A)
SAH  A 502 ( 3.8A)
None
SAH  A 502 (-4.2A)
0.82A 3jb2A-4rvhA:
7.0
3jb2A-4rvhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
6 / 12 ILE A 113
GLY A 114
PRO A 136
ALA A 137
PHE A 156
VAL A 179
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.0A)
SAH  A 502 ( 3.8A)
None
SAH  A 502 (-4.2A)
0.55A 3jb3A-4rvhA:
8.1
3jb3A-4rvhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 9 ALA A 190
LEU A 238
VAL A 263
ILE A 230
ILE A 205
None
1.23A 3jw3B-4rvhA:
2.5
3jw3B-4rvhA:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
7 / 12 TYR A  77
TYR A  79
GLU A 112
ILE A 113
PHE A 155
PHE A 156
ILE A 183
SAH  A 502 (-4.3A)
3YN  A 503 (-3.4A)
None
SAH  A 502 (-4.7A)
SAH  A 502 (-4.8A)
None
SAH  A 502 (-4.2A)
0.50A 3ndiA-4rvhA:
54.3
3ndiA-4rvhA:
39.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 5 LEU A 360
LEU A 384
GLY A 326
GLY A 324
None
None
CSO  A 349 ( 3.0A)
None
0.76A 3si7C-4rvhA:
undetectable
3si7D-4rvhA:
1.6
3si7C-4rvhA:
21.33
3si7D-4rvhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 10 PHE A 203
SER A 201
LEU A 196
PHE A 156
VAL A 174
None
1.50A 3u9fI-4rvhA:
undetectable
3u9fI-4rvhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 10 PHE A 203
SER A 201
LEU A 196
PHE A 156
VAL A 174
None
1.50A 3u9fR-4rvhA:
undetectable
3u9fR-4rvhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 12 LEU A 197
ILE A 183
ILE A 113
VAL A 174
LEU A 111
None
SAH  A 502 (-4.2A)
SAH  A 502 (-4.7A)
None
None
1.10A 3w67B-4rvhA:
undetectable
3w67B-4rvhA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 5 PHE A 180
LEU A  61
GLY A 231
ILE A 205
VAL A 261
None
1.37A 3wrkA-4rvhA:
undetectable
3wrkA-4rvhA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 12 GLY A 114
ILE A 134
VAL A 179
HIS A 182
ILE A 183
SAH  A 502 (-3.5A)
None
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
0.70A 4ax8A-4rvhA:
12.6
4ax8A-4rvhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 12 GLY A 114
ILE A 134
VAL A 179
HIS A 182
ILE A 183
SAH  A 502 (-3.5A)
None
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
0.66A 4azvA-4rvhA:
13.2
4azvA-4rvhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 7 ILE A 322
LEU A 345
LYS A 330
GLY A 331
None
None
3YN  A 503 (-2.9A)
None
1.06A 4hbfA-4rvhA:
undetectable
4hbfA-4rvhA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 7 ILE A 322
LEU A 345
LYS A 330
GLY A 331
None
None
3YN  A 503 (-2.9A)
None
1.02A 4hc3A-4rvhA:
undetectable
4hc3A-4rvhA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 8 LEU A  51
VAL A  68
TYR A 223
LEU A  64
None
1.15A 4q0bA-4rvhA:
undetectable
4q0bA-4rvhA:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVD_A_ACTA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 4 ALA A 373
LYS A 374
TYR A 381
GLU A 396
CSO  A 349 ( 3.9A)
None
None
None
0.16A 4rvdA-4rvhA:
67.3
4rvdA-4rvhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 12 ILE A 113
GLY A 114
ALA A 141
PHE A 156
ARG A 177
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
None
None
SAH  A 502 (-3.4A)
1.07A 4rvdA-4rvhA:
67.3
4rvdA-4rvhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
12 / 12 TYR A  74
TYR A  77
ILE A 113
GLY A 114
PRO A 136
ALA A 137
PHE A 156
ARG A 177
HIS A 178
VAL A 179
HIS A 182
ILE A 183
SAH  A 502 (-3.6A)
SAH  A 502 (-4.3A)
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.0A)
SAH  A 502 ( 3.8A)
None
SAH  A 502 (-3.4A)
3YN  A 503 (-4.3A)
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
0.10A 4rvdA-4rvhA:
67.3
4rvdA-4rvhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVG_A_ACTA504_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 4 ALA A 373
LYS A 374
TYR A 381
GLU A 396
CSO  A 349 ( 3.9A)
None
None
None
0.11A 4rvgA-4rvhA:
68.7
4rvgA-4rvhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
6 / 12 THR A  81
ILE A 113
GLY A 114
ALA A 141
PHE A 156
ARG A 177
SAH  A 502 (-2.8A)
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
None
None
SAH  A 502 (-3.4A)
1.22A 4rvgA-4rvhA:
68.7
4rvgA-4rvhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
12 / 12 TYR A  74
THR A  81
ILE A 113
GLY A 114
ASN A 116
PRO A 136
ALA A 137
PHE A 156
ARG A 177
VAL A 179
HIS A 182
ILE A 183
SAH  A 502 (-3.6A)
SAH  A 502 (-2.8A)
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.0A)
SAH  A 502 (-4.0A)
SAH  A 502 ( 3.8A)
None
SAH  A 502 (-3.4A)
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
0.12A 4rvgA-4rvhA:
68.7
4rvgA-4rvhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 11 ARG A 177
ALA A 123
VAL A  95
HIS A  90
VAL A  94
SAH  A 502 (-3.4A)
None
None
None
None
1.26A 5eb5A-4rvhA:
undetectable
5eb5A-4rvhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 10 ARG A 177
ALA A 123
VAL A  95
HIS A  90
VAL A  94
SAH  A 502 (-3.4A)
None
None
None
None
1.18A 5eb5B-4rvhA:
undetectable
5eb5B-4rvhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 12 GLY A 103
VAL A 110
THR A 131
VAL A  97
ALA A  96
None
0.95A 5kocA-4rvhA:
13.0
5kocA-4rvhA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 7 HIS A  90
HIS A 178
VAL A 254
SER A 258
None
3YN  A 503 (-4.3A)
None
None
1.03A 5m8rA-4rvhA:
undetectable
5m8rA-4rvhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 8 HIS A  90
HIS A 178
VAL A 254
SER A 258
None
3YN  A 503 (-4.3A)
None
None
1.02A 5m8rB-4rvhA:
undetectable
5m8rB-4rvhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 12 ASP A 135
LEU A 244
PHE A 239
ILE A 230
ALA A 181
SAH  A 502 (-2.7A)
None
None
None
None
1.16A 5vc0A-4rvhA:
undetectable
5vc0A-4rvhA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
4 / 6 GLU A 283
TYR A 209
GLY A 257
GLY A 256
None
0.89A 5x7pB-4rvhA:
undetectable
5x7pB-4rvhA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus)
5 / 12 GLY A 257
GLY A 256
GLY A 176
HIS A 226
GLU A 112
None
None
None
3YN  A 503 (-4.5A)
None
0.99A 6gngB-4rvhA:
2.8
6gngB-4rvhA:
22.52