SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1B02_A_C2FA281_0 (PROTEIN (THYMIDYLATE SYNTHASE))	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 11	ALA A 188 TRP A 162 LEU A 287 LEU A 157 GLY A 156	None	1.15A	1b02A-4rvsA: undetectable	1b02A-4rvsA: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NH8_A_HISA289_0 (ATP PHOSPHORIBOSYLTRANSF ERASE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	4 / 5	ASP A 219 LEU A 159 ALA A 240 LEU A 241	None	1.14A	1nh8A-4rvsA: undetectable	1nh8A-4rvsA: 25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_A_SAMA300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 12	GLY A 261 GLY A 211 GLY A 213 THR A 209 LEU A 208	None	0.95A	2oxtA-4rvsA: 5.4	2oxtA-4rvsA: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCV_A_ASDA1224_1 (GLUTATHIONE S-TRANSFERASE A3)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	4 / 7	ALA A 120 LEU A 124 ALA A 284 PHE A 280	None	1.17A	2vcvA-4rvsA: undetectable	2vcvA-4rvsA: 22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VUF_A_FUAA2002_1 (SERUM ALBUMIN)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	4 / 9	ILE A 171 PHE A 201 ALA A 202 VAL A 205	None	0.70A	2vufA-4rvsA: undetectable	2vufA-4rvsA: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WA2_A_SAMA1248_0 (NON-STRUCTURAL PROTEIN 5)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 12	GLY A 261 GLY A 211 GLY A 213 THR A 209 LEU A 208	None	0.96A	2wa2A-4rvsA: 6.1	2wa2A-4rvsA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7K_C_SALC1302_1 (LYSR-TYPE REGULATORY PROTEIN)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 12	ILE A 5 PHE A 58 GLY A 61 HIS A 313 ARG A 48	None	1.17A	2y7kC-4rvsA: undetectable	2y7kC-4rvsA: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELU_A_SAMA4633_0 (METHYLTRANSFERASE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 12	GLY A 261 GLY A 211 GLY A 213 THR A 209 LEU A 208	None	1.10A	3eluA-4rvsA: 5.6	3eluA-4rvsA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K2H_B_LYAB513_1 (DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 12	ALA A 188 TRP A 162 LEU A 287 LEU A 157 GLY A 156	None	1.15A	3k2hB-4rvsA: undetectable	3k2hB-4rvsA: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SM2_A_478A126_2 (GAG-PRO-POL POLYPROTEIN)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 11	VAL A 205 GLY A 213 ALA A 234 LEU A 192 TYR A 218	None	1.03A	3sm2B-4rvsA: undetectable	3sm2B-4rvsA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SO9_A_017A100_2 (HIV-1 PROTEASE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 12	ASP A 144 VAL A 146 ILE A 158 THR A 172 VAL A 170	None	0.98A	3so9B-4rvsA: undetectable	3so9B-4rvsA: 15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRI_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	4 / 5	GLY A 151 THR A 160 ILE A 171 VAL A 170	None	0.75A	3wriA-4rvsA: undetectable	3wriA-4rvsA: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRI_B_CAMB502_0 (CAMPHOR 5-MONOOXYGENASE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	4 / 5	GLY A 151 THR A 160 ILE A 171 VAL A 170	None	0.76A	3wriB-4rvsA: undetectable	3wriB-4rvsA: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_B_ACTB701_0 (RNA (33-MER) RNA POLYMERASE 3D-POL)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	3 / 3	HIS A 313 GLY A 61 ILE A 60	None	0.64A	4k50A-4rvsA: undetectable	4k50A-4rvsA: 19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_J_ACTJ701_0 (RNA (33-MER) RNA POLYMERASE 3D-POL)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	3 / 3	HIS A 313 GLY A 61 ILE A 60	None	0.62A	4k50I-4rvsA: undetectable	4k50I-4rvsA: 19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MUB_A_OAQA302_0 (SULFOTRANSFERASE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 12	LEU A 134 VAL A 148 GLY A 222 PHE A 242 THR A 225	None	1.40A	4mubA-4rvsA: undetectable	4mubA-4rvsA: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O2B_B_LOCB503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA-2B CHAIN)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	3 / 3	SER A 232 ALA A 234 VAL A 235	None	0.61A	4o2bA-4rvsA: 3.1	4o2bA-4rvsA: 22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PGH_A_SAMA401_0 (CAFFEIC ACID O-METHYLTRANSFERASE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 11	SER A 229 GLY A 243 GLY A 220 THR A 225 VAL A 155	None	1.18A	4pghA-4rvsA: 2.4	4pghA-4rvsA: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVL_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 11	ALA A 186 ALA A 188 GLY A 154 GLY A 153 ALA A 152	None	1.04A	4qvlK-4rvsA: undetectable 4qvlL-4rvsA: undetectable	4qvlK-4rvsA: 22.35 4qvlL-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVL_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 11	ALA A 186 ALA A 188 GLY A 154 GLY A 153 ALA A 152	None	1.04A	4qvlY-4rvsA: undetectable 4qvlZ-4rvsA: undetectable	4qvlY-4rvsA: 22.35 4qvlZ-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVM_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 9	ALA A 186 ALA A 188 GLY A 154 GLY A 153 ALA A 152	None	1.05A	4qvmK-4rvsA: undetectable 4qvmL-4rvsA: undetectable	4qvmK-4rvsA: 22.06 4qvmL-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVM_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 10	ALA A 186 ALA A 188 GLY A 154 GLY A 153 ALA A 152	None	1.05A	4qvmY-4rvsA: undetectable 4qvmZ-4rvsA: undetectable	4qvmY-4rvsA: 22.06 4qvmZ-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	4 / 8	THR A 160 GLY A 153 GLY A 154 VAL A 155	None	0.79A	4qvvK-4rvsA: undetectable 4qvvL-4rvsA: undetectable	4qvvK-4rvsA: 20.72 4qvvL-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	4 / 8	THR A 160 GLY A 153 GLY A 154 VAL A 155	None	0.79A	4qvvY-4rvsA: undetectable 4qvvZ-4rvsA: undetectable	4qvvY-4rvsA: 20.72 4qvvZ-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW1_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 10	ALA A 186 ALA A 188 GLY A 154 GLY A 153 ALA A 152	None	1.06A	4qw1Y-4rvsA: undetectable 4qw1Z-4rvsA: undetectable	4qw1Y-4rvsA: 20.42 4qw1Z-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW3_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 10	ALA A 186 ALA A 188 GLY A 154 GLY A 153 ALA A 152	None	1.05A	4qw3K-4rvsA: undetectable 4qw3L-4rvsA: undetectable	4qw3K-4rvsA: 22.35 4qw3L-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW3_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 10	ALA A 186 ALA A 188 GLY A 154 GLY A 153 ALA A 152	None	1.05A	4qw3Y-4rvsA: undetectable 4qw3Z-4rvsA: undetectable	4qw3Y-4rvsA: 22.35 4qw3Z-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WCX_C_SAMC503_0 (BIOTIN AND THIAMIN SYNTHESIS ASSOCIATED)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 12	GLY A 292 GLU A 294 LEU A 166 ALA A 130 HIS A 131	None	1.22A	4wcxC-4rvsA: undetectable	4wcxC-4rvsA: 19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WCX_C_SAMC503_0 (BIOTIN AND THIAMIN SYNTHESIS ASSOCIATED)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 12	GLY A 292 GLU A 294 LEU A 166 LEU A 134 HIS A 131	None	1.21A	4wcxC-4rvsA: undetectable	4wcxC-4rvsA: 19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0X_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 9	ALA A 186 ALA A 188 GLY A 154 GLY A 153 ALA A 152	None	1.05A	5d0xK-4rvsA: undetectable 5d0xL-4rvsA: undetectable	5d0xK-4rvsA: 21.99 5d0xL-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0X_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 9	ALA A 186 ALA A 188 GLY A 154 GLY A 153 ALA A 152	None	1.05A	5d0xY-4rvsA: undetectable 5d0xZ-4rvsA: undetectable	5d0xY-4rvsA: 21.99 5d0xZ-4rvsA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EYP_B_LOCB502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	3 / 3	SER A 232 ALA A 234 VAL A 235	None	0.59A	5eypA-4rvsA: 3.1	5eypA-4rvsA: 22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I3C_A_AC2A301_1 (PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 9	SER A 324 GLY A 39 ALA A 312 VAL A 40 ILE A 38	None	1.36A	5i3cA-4rvsA: undetectable	5i3cA-4rvsA: 23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I3C_B_AC2B301_1 (PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 10	SER A 92 ALA A 121 VAL A 64 GLU A 63 ILE A 33	None	1.23A	5i3cB-4rvsA: undetectable	5i3cB-4rvsA: 23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CZM_A_HISA402_0 (ATP PHOSPHORIBOSYLTRANSF ERASE CATALYTIC SUBUNIT)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	5 / 10	LEU A 182 THR A 172 VAL A 191 ALA A 188 LEU A 157	None	1.12A	6czmA-4rvsA: undetectable 6czmC-4rvsA: undetectable	6czmA-4rvsA: 23.56 6czmC-4rvsA: 23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6D8P_B_ACTB804_0 (UNCHARACTERIZED PROTEIN)	4rvs	PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN) (Mycobacterium tuberculosis)	4 / 4	HIS A 149 VAL A 205 LEU A 147 ALA A 228	None	0.88A	6d8pB-4rvsA: 2.5	6d8pB-4rvsA: 17.74

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1B02_A_C2FA281_0","PROTEIN (THYMIDYLATE SYNTHASE)","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 188;TRP A 162;LEU A 287;LEU A 157;GLY A 156","None","1.15A","1b02A-4rvsA:undetectable","1b02A-4rvsA:21.29"],["1NH8_A_HISA289_0","ATP PHOSPHORIBOSYLTRANSFERASE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",4,"ASP A 219;LEU A 159;ALA A 240;LEU A 241","None","1.14A","1nh8A-4rvsA:undetectable","1nh8A-4rvsA:25.63"],["2OXT_A_SAMA300_0","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"GLY A 261;GLY A 211;GLY A 213;THR A 209;LEU A 208","None","0.95A","2oxtA-4rvsA:5.4","2oxtA-4rvsA:21.45"],["2VCV_A_ASDA1224_1","GLUTATHIONE S-TRANSFERASE A3","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",4,"ALA A 120;LEU A 124;ALA A 284;PHE A 280","None","1.17A","2vcvA-4rvsA:undetectable","2vcvA-4rvsA:22.80"],["2VUF_A_FUAA2002_1","SERUM ALBUMIN","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",4,"ILE A 171;PHE A 201;ALA A 202;VAL A 205","None","0.70A","2vufA-4rvsA:undetectable","2vufA-4rvsA:20.27"],["2WA2_A_SAMA1248_0","NON-STRUCTURAL PROTEIN 5","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"GLY A 261;GLY A 211;GLY A 213;THR A 209;LEU A 208","None","0.96A","2wa2A-4rvsA:6.1","2wa2A-4rvsA:21.97"],["2Y7K_C_SALC1302_1","LYSR-TYPE REGULATORY PROTEIN","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ILE A   5;PHE A  58;GLY A  61;HIS A 313;ARG A  48","None","1.17A","2y7kC-4rvsA:undetectable","2y7kC-4rvsA:20.43"],["3ELU_A_SAMA4633_0","METHYLTRANSFERASE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"GLY A 261;GLY A 211;GLY A 213;THR A 209;LEU A 208","None","1.10A","3eluA-4rvsA:5.6","3eluA-4rvsA:undetectable"],["3K2H_B_LYAB513_1","DIHYDROFOLATE REDUCTASE\/THYMIDYLATE SYNTHASE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 188;TRP A 162;LEU A 287;LEU A 157;GLY A 156","None","1.15A","3k2hB-4rvsA:undetectable","3k2hB-4rvsA:21.09"],["3SM2_A_478A126_2","GAG-PRO-POL POLYPROTEIN;GAG-PRO-POL POLYPROTEIN","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"VAL A 205;GLY A 213;ALA A 234;LEU A 192;TYR A 218","None","1.03A","3sm2B-4rvsA:undetectable","3sm2B-4rvsA:19.33"],["3SO9_A_017A100_2","HIV-1 PROTEASE;HIV-1 PROTEASE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ASP A 144;VAL A 146;ILE A 158;THR A 172;VAL A 170","None","0.98A","3so9B-4rvsA:undetectable","3so9B-4rvsA:15.20"],["3WRI_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",4,"GLY A 151;THR A 160;ILE A 171;VAL A 170","None","0.75A","3wriA-4rvsA:undetectable","3wriA-4rvsA:23.13"],["3WRI_B_CAMB502_0","CAMPHOR 5-MONOOXYGENASE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",4,"GLY A 151;THR A 160;ILE A 171;VAL A 170","None","0.76A","3wriB-4rvsA:undetectable","3wriB-4rvsA:23.13"],["4K50_B_ACTB701_0","RNA (33-MER);RNA POLYMERASE 3D-POL","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",3,"HIS A 313;GLY A  61;ILE A  60","None","0.64A","4k50A-4rvsA:undetectable","4k50A-4rvsA:19.53"],["4K50_J_ACTJ701_0","RNA (33-MER);RNA POLYMERASE 3D-POL","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",3,"HIS A 313;GLY A  61;ILE A  60","None","0.62A","4k50I-4rvsA:undetectable","4k50I-4rvsA:19.53"],["4MUB_A_OAQA302_0","SULFOTRANSFERASE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"LEU A 134;VAL A 148;GLY A 222;PHE A 242;THR A 225","None","1.40A","4mubA-4rvsA:undetectable","4mubA-4rvsA:20.30"],["4O2B_B_LOCB503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",3,"SER A 232;ALA A 234;VAL A 235","None","0.61A","4o2bA-4rvsA:3.1","4o2bA-4rvsA:22.84"],["4PGH_A_SAMA401_0","CAFFEIC ACID O-METHYLTRANSFERASE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"SER A 229;GLY A 243;GLY A 220;THR A 225;VAL A 155","None","1.18A","4pghA-4rvsA:2.4","4pghA-4rvsA:22.88"],["4QVL_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 186;ALA A 188;GLY A 154;GLY A 153;ALA A 152","None","1.04A","4qvlK-4rvsA:undetectable;4qvlL-4rvsA:undetectable","4qvlK-4rvsA:22.35;4qvlL-4rvsA:22.12"],["4QVL_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 186;ALA A 188;GLY A 154;GLY A 153;ALA A 152","None","1.04A","4qvlY-4rvsA:undetectable;4qvlZ-4rvsA:undetectable","4qvlY-4rvsA:22.35;4qvlZ-4rvsA:22.12"],["4QVM_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 186;ALA A 188;GLY A 154;GLY A 153;ALA A 152","None","1.05A","4qvmK-4rvsA:undetectable;4qvmL-4rvsA:undetectable","4qvmK-4rvsA:22.06;4qvmL-4rvsA:22.12"],["4QVM_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 186;ALA A 188;GLY A 154;GLY A 153;ALA A 152","None","1.05A","4qvmY-4rvsA:undetectable;4qvmZ-4rvsA:undetectable","4qvmY-4rvsA:22.06;4qvmZ-4rvsA:22.12"],["4QVV_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",4,"THR A 160;GLY A 153;GLY A 154;VAL A 155","None","0.79A","4qvvK-4rvsA:undetectable;4qvvL-4rvsA:undetectable","4qvvK-4rvsA:20.72;4qvvL-4rvsA:22.12"],["4QVV_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",4,"THR A 160;GLY A 153;GLY A 154;VAL A 155","None","0.79A","4qvvY-4rvsA:undetectable;4qvvZ-4rvsA:undetectable","4qvvY-4rvsA:20.72;4qvvZ-4rvsA:22.12"],["4QW1_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 186;ALA A 188;GLY A 154;GLY A 153;ALA A 152","None","1.06A","4qw1Y-4rvsA:undetectable;4qw1Z-4rvsA:undetectable","4qw1Y-4rvsA:20.42;4qw1Z-4rvsA:22.12"],["4QW3_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 186;ALA A 188;GLY A 154;GLY A 153;ALA A 152","None","1.05A","4qw3K-4rvsA:undetectable;4qw3L-4rvsA:undetectable","4qw3K-4rvsA:22.35;4qw3L-4rvsA:22.12"],["4QW3_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 186;ALA A 188;GLY A 154;GLY A 153;ALA A 152","None","1.05A","4qw3Y-4rvsA:undetectable;4qw3Z-4rvsA:undetectable","4qw3Y-4rvsA:22.35;4qw3Z-4rvsA:22.12"],["4WCX_C_SAMC503_0","BIOTIN AND THIAMIN SYNTHESIS ASSOCIATED","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"GLY A 292;GLU A 294;LEU A 166;ALA A 130;HIS A 131","None","1.22A","4wcxC-4rvsA:undetectable","4wcxC-4rvsA:19.96"],["4WCX_C_SAMC503_0","BIOTIN AND THIAMIN SYNTHESIS ASSOCIATED","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"GLY A 292;GLU A 294;LEU A 166;LEU A 134;HIS A 131","None","1.21A","4wcxC-4rvsA:undetectable","4wcxC-4rvsA:19.96"],["5D0X_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 186;ALA A 188;GLY A 154;GLY A 153;ALA A 152","None","1.05A","5d0xK-4rvsA:undetectable;5d0xL-4rvsA:undetectable","5d0xK-4rvsA:21.99;5d0xL-4rvsA:22.12"],["5D0X_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"ALA A 186;ALA A 188;GLY A 154;GLY A 153;ALA A 152","None","1.05A","5d0xY-4rvsA:undetectable;5d0xZ-4rvsA:undetectable","5d0xY-4rvsA:21.99;5d0xZ-4rvsA:22.12"],["5EYP_B_LOCB502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",3,"SER A 232;ALA A 234;VAL A 235","None","0.59A","5eypA-4rvsA:3.1","5eypA-4rvsA:22.84"],["5I3C_A_AC2A301_1","PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"SER A 324;GLY A  39;ALA A 312;VAL A  40;ILE A  38","None","1.36A","5i3cA-4rvsA:undetectable","5i3cA-4rvsA:23.55"],["5I3C_B_AC2B301_1","PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"SER A  92;ALA A 121;VAL A  64;GLU A  63;ILE A  33","None","1.23A","5i3cB-4rvsA:undetectable","5i3cB-4rvsA:23.55"],["6CZM_A_HISA402_0","ATP PHOSPHORIBOSYLTRANSFERASE CATALYTIC SUBUNIT","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",5,"LEU A 182;THR A 172;VAL A 191;ALA A 188;LEU A 157","None","1.12A","6czmA-4rvsA:undetectable;6czmC-4rvsA:undetectable","6czmA-4rvsA:23.56;6czmC-4rvsA:23.56"],["6D8P_B_ACTB804_0","UNCHARACTERIZED PROTEIN","4rvs","PROBABLE QUINONE REDUCTASE QOR (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN HOMOLOG PROTEIN)","Mycobacterium tuberculosis",4,"HIS A 149;VAL A 205;LEU A 147;ALA A 228","None","0.88A","6d8pB-4rvsA:2.5","6d8pB-4rvsA:17.74"]]