SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rvw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 8 LEU A  84
SER A 124
ASN A 127
ASP A  95
 None
 0.86A 1ig3A-4rvwA:
undetectable
1ig3B-4rvwA:
undetectable		 1ig3A-4rvwA:
17.66
1ig3B-4rvwA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 7 ASP A  95
LEU A  84
SER A 124
ASN A 127
 None
 0.86A 1ig3A-4rvwA:
undetectable
1ig3B-4rvwA:
undetectable		 1ig3A-4rvwA:
17.66
1ig3B-4rvwA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 12 GLY A  67
GLY A  66
ASN A  48
TYR A 191
ASP A  51
 None
 1.17A 1likA-4rvwA:
undetectable		 1likA-4rvwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 4 ARG A 232
LEU A  49
ASN A  48
VAL A 104
 None
 1.18A 1lqtA-4rvwA:
undetectable		 1lqtA-4rvwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 4 ARG A 232
LEU A  49
ASN A  48
VAL A 104
 None
 1.17A 1lqtB-4rvwA:
undetectable		 1lqtB-4rvwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 4 ARG A 232
LEU A  49
ASN A  48
VAL A 104
 None
 1.18A 1lquA-4rvwA:
undetectable		 1lquA-4rvwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 4 ARG A 232
LEU A  49
ASN A  48
VAL A 104
 None
 1.16A 1lquB-4rvwA:
undetectable		 1lquB-4rvwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 6 VAL A 119
THR A 120
LEU A 115
ARG A 116
 None
 1.09A 1s8fB-4rvwA:
undetectable		 1s8fB-4rvwA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 12 LEU A 537
ALA A 536
LEU A 535
ASN A 534
LYS A 476
 None
 1.17A 1sa1A-4rvwA:
undetectable
1sa1B-4rvwA:
undetectable		 1sa1A-4rvwA:
19.57
1sa1B-4rvwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 12 LEU A 537
ALA A 536
LEU A 535
ASN A 534
LYS A 476
 None
 1.18A 1sa1C-4rvwA:
undetectable
1sa1D-4rvwA:
undetectable		 1sa1C-4rvwA:
19.57
1sa1D-4rvwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 ARG A 307
ARG A 337
ILE A 304
 None
 0.81A 1uobA-4rvwA:
undetectable		 1uobA-4rvwA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 HIS A 677
ASP A 702
ASN A 160
 None
 0.86A 1wg8B-4rvwA:
undetectable		 1wg8B-4rvwA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 ARG A 201
SER A  69
TYR A  64
 None
 0.77A 1x70A-4rvwA:
3.4		 1x70A-4rvwA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 12 ALA A 135
LEU A  42
ILE A  37
ILE A  36
LEU A  53
 None
 1.18A 1xdkB-4rvwA:
undetectable		 1xdkB-4rvwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 6 SER A 462
GLU A 515
SER A 489
GLN A 491
 None
 1.08A 2cl5B-4rvwA:
undetectable		 2cl5B-4rvwA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 6 LEU A 397
HIS A 499
GLU A 506
HIS A 100
 None
ZN  A 801 (-3.0A)
None
ZN  A 801 (-3.0A)
 0.83A 2ow9A-4rvwA:
undetectable		 2ow9A-4rvwA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 8 LEU A 131
ARG A 358
SER A 482
VAL A 410
 None
 1.19A 2qd2A-4rvwA:
undetectable		 2qd2A-4rvwA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 8 SER A 217
VAL A 148
GLY A 147
MET A 143
 None
 1.15A 2qd3A-4rvwA:
undetectable		 2qd3A-4rvwA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 PRO A 194
ASN A 706
ARG A 724
 None
 0.85A 2qeuB-4rvwA:
undetectable		 2qeuB-4rvwA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 9 THR A 504
VAL A 569
GLY A 497
MET A 396
GLU A 492
 None
 1.46A 2w98A-4rvwA:
undetectable		 2w98A-4rvwA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 5 LEU A 397
HIS A 499
GLU A 506
HIS A 100
 None
ZN  A 801 (-3.0A)
None
ZN  A 801 (-3.0A)
 0.77A 3kecA-4rvwA:
undetectable		 3kecA-4rvwA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 6 GLU A 582
THR A 480
ALA A 536
ALA A 523
 None
 1.21A 3ns1C-4rvwA:
undetectable		 3ns1C-4rvwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 LYS A 370
ARG A 368
LYS A 476
 None
 1.34A 3okxA-4rvwA:
undetectable		 3okxA-4rvwA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 12 LEU A 640
GLY A  55
GLY A 599
SER A 598
ALA A  61
 None
 1.15A 3ou7B-4rvwA:
undetectable		 3ou7B-4rvwA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 6 LEU A 397
HIS A 499
GLU A 506
HIS A 100
 None
ZN  A 801 (-3.0A)
None
ZN  A 801 (-3.0A)
 0.88A 4a7bA-4rvwA:
undetectable		 4a7bA-4rvwA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 12 ARG A 486
ILE A  59
GLY A  78
GLY A 130
LEU A 131
 None
 0.99A 4e1gB-4rvwA:
undetectable		 4e1gB-4rvwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 11 HIS A 499
ILE A 304
GLY A  65
GLY A  66
ASN A  48
 ZN  A 801 (-3.0A)
None
None
None
None
 1.33A 4fglA-4rvwA:
undetectable
4fglB-4rvwA:
undetectable		 4fglA-4rvwA:
14.40
4fglB-4rvwA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 ASP A 305
ARG A 307
ASP A 208
 None
 0.89A 4fp9F-4rvwA:
undetectable		 4fp9F-4rvwA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 5 LEU A  53
ARG A 116
PRO A 636
SER A 713
 None
 1.45A 4kmmB-4rvwA:
undetectable		 4kmmB-4rvwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 5 SER A 166
GLY A 153
ARG A  43
GLU A 151
 None
 1.30A 4r82A-4rvwA:
undetectable
4r82B-4rvwA:
undetectable		 4r82A-4rvwA:
14.43
4r82B-4rvwA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 7 ALA A 384
ASP A  95
GLY A  91
GLU A  89
 None
 0.90A 5bs8A-4rvwA:
undetectable
5bs8C-4rvwA:
undetectable
5bs8D-4rvwA:
undetectable		 5bs8A-4rvwA:
21.56
5bs8C-4rvwA:
21.56
5bs8D-4rvwA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 7 ALA A 384
ASP A  95
GLY A  91
GLU A  89
 None
 0.91A 5bs8A-4rvwA:
undetectable
5bs8B-4rvwA:
undetectable
5bs8C-4rvwA:
undetectable		 5bs8A-4rvwA:
21.56
5bs8B-4rvwA:
16.64
5bs8C-4rvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 7 SER A 209
ARG A  43
GLY A 167
GLU A 151
 None
 0.98A 5btaA-4rvwA:
undetectable
5btaC-4rvwA:
undetectable
5btaD-4rvwA:
undetectable		 5btaA-4rvwA:
21.69
5btaC-4rvwA:
21.69
5btaD-4rvwA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 6 SER A 209
ARG A  43
GLY A 167
GLU A 151
 None
 0.95A 5btaA-4rvwA:
undetectable
5btaB-4rvwA:
undetectable
5btaC-4rvwA:
undetectable		 5btaA-4rvwA:
21.69
5btaB-4rvwA:
16.64
5btaC-4rvwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 6 SER A 209
ARG A  43
GLY A 167
GLU A 151
 None
 0.99A 5btcA-4rvwA:
undetectable
5btcC-4rvwA:
undetectable
5btcD-4rvwA:
undetectable		 5btcA-4rvwA:
21.69
5btcC-4rvwA:
21.69
5btcD-4rvwA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 6 SER A 209
ARG A  43
GLY A 167
GLU A 151
 None
 0.96A 5btcA-4rvwA:
undetectable
5btcB-4rvwA:
undetectable
5btcC-4rvwA:
undetectable		 5btcA-4rvwA:
21.69
5btcB-4rvwA:
16.64
5btcC-4rvwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 7 ALA A 384
ASP A  95
GLY A  91
GLU A  89
 None
 0.88A 5btdA-4rvwA:
undetectable
5btdB-4rvwA:
undetectable
5btdC-4rvwA:
undetectable		 5btdA-4rvwA:
21.56
5btdB-4rvwA:
16.64
5btdC-4rvwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 7 ALA A 384
ASP A  95
GLY A  91
GLU A  89
 None
 0.88A 5btdA-4rvwA:
undetectable
5btdC-4rvwA:
undetectable
5btdD-4rvwA:
undetectable		 5btdA-4rvwA:
21.56
5btdC-4rvwA:
21.56
5btdD-4rvwA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 7 SER A 209
ARG A  43
GLY A 167
GLU A 151
 None
 0.94A 5btfA-4rvwA:
undetectable
5btfB-4rvwA:
undetectable
5btfC-4rvwA:
undetectable		 5btfA-4rvwA:
21.69
5btfB-4rvwA:
16.64
5btfC-4rvwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 7 SER A 209
ARG A  43
GLY A 167
GLU A 151
 None
 1.00A 5btfA-4rvwA:
undetectable
5btfC-4rvwA:
undetectable
5btfD-4rvwA:
undetectable		 5btfA-4rvwA:
21.69
5btfC-4rvwA:
21.69
5btfD-4rvwA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 7 ALA A 384
ASP A  95
GLY A  91
GLU A  89
 None
 0.90A 5btgA-4rvwA:
undetectable
5btgC-4rvwA:
undetectable
5btgD-4rvwA:
undetectable		 5btgA-4rvwA:
21.56
5btgC-4rvwA:
21.56
5btgD-4rvwA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 12 LEU A  84
GLY A  88
SER A 406
GLU A 427
LEU A 131
 None
 1.32A 5czyA-4rvwA:
undetectable		 5czyA-4rvwA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 8 VAL A 193
ALA A 192
GLY A 159
GLY A 189
 None
 0.91A 5e26C-4rvwA:
undetectable
5e26D-4rvwA:
undetectable		 5e26C-4rvwA:
19.65
5e26D-4rvwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 5 SER A 462
GLU A 515
SER A 489
GLN A 491
 None
 1.09A 5fhrB-4rvwA:
undetectable		 5fhrB-4rvwA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 8 ASN A 414
GLU A 325
HIS A 363
THR A  31
 None
 1.36A 5hqaA-4rvwA:
undetectable		 5hqaA-4rvwA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 ARG A 195
PRO A 194
ASN A 703
 None
 1.08A 5jwaA-4rvwA:
undetectable
5jwaH-4rvwA:
undetectable		 5jwaA-4rvwA:
20.95
5jwaH-4rvwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 8 THR A 120
THR A 480
THR A  31
SER A  33
 None
 0.91A 5l4eA-4rvwA:
undetectable
5l4eB-4rvwA:
undetectable
5l4eC-4rvwA:
undetectable
5l4eD-4rvwA:
undetectable
5l4eE-4rvwA:
undetectable		 5l4eA-4rvwA:
18.58
5l4eB-4rvwA:
18.58
5l4eC-4rvwA:
18.58
5l4eD-4rvwA:
18.58
5l4eE-4rvwA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 4 SER A 714
ALA A 711
GLN A 664
THR A 674
 None
 1.42A 5n0rA-4rvwA:
undetectable		 5n0rA-4rvwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 4 SER A 714
ALA A 711
GLN A 664
THR A 674
 None
 1.42A 5n0sA-4rvwA:
undetectable		 5n0sA-4rvwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 4 SER A 714
ALA A 711
GLN A 664
THR A 674
 None
 1.41A 5n0wA-4rvwA:
undetectable		 5n0wA-4rvwA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 4 SER A 714
ALA A 711
GLN A 664
THR A 674
 None
 1.43A 5n0xA-4rvwA:
undetectable		 5n0xA-4rvwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 HIS A  86
ASP A 133
HIS A  87
 ZN  A 802 (-3.6A)
None
ZN  A 802 (-3.2A)
 0.76A 5n1tW-4rvwA:
undetectable		 5n1tW-4rvwA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NVP_A_ACAA18_1
(ENVELOPE
GLYCOPROTEIN,GP41)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 12 SER A  33
ASN A 468
LEU A 479
GLU A 521
LEU A 522
 None
 0.96A 5nvpA-4rvwA:
undetectable		 5nvpA-4rvwA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NVP_A_ACAA18_1
(ENVELOPE
GLYCOPROTEIN,GP41)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 12 SER A  33
LYS A 476
LEU A 479
GLU A 521
LEU A 522
 None
 1.26A 5nvpA-4rvwA:
undetectable		 5nvpA-4rvwA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 ARG A 486
PRO A 488
TYR A 545
 None
 1.08A 5tzoB-4rvwA:
undetectable		 5tzoB-4rvwA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 12 ALA A 135
LEU A  42
ILE A  37
ILE A  36
LEU A  53
 None
 1.27A 5uanB-4rvwA:
undetectable		 5uanB-4rvwA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 6 ILE A 359
LEU A 361
PHE A 324
HIS A 363
 None
 0.99A 5vkqA-4rvwA:
undetectable
5vkqB-4rvwA:
undetectable		 5vkqA-4rvwA:
17.88
5vkqB-4rvwA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 6 ILE A 359
LEU A 361
PHE A 324
HIS A 363
 None
 0.97A 5vkqA-4rvwA:
undetectable
5vkqD-4rvwA:
undetectable		 5vkqA-4rvwA:
17.88
5vkqD-4rvwA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 GLY A  67
ASN A  48
ARG A 232
 None
 0.44A 5w7bD-4rvwA:
undetectable		 5w7bD-4rvwA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 TYR A 311
ASP A 231
ASP A 335
 None
 0.76A 5x6yA-4rvwA:
undetectable		 5x6yA-4rvwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 5 PRO A  71
VAL A 132
GLY A 583
VAL A  56
 None
 1.02A 6ak3B-4rvwA:
undetectable		 6ak3B-4rvwA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 ARG A 486
LYS A  82
ARG A 232
 None
 1.00A 6c06D-4rvwA:
undetectable		 6c06D-4rvwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4rvw ZNUD
(Neisseria
meningitidis) 		4 / 8 ASP A 133
ARG A 328
GLU A 360
VAL A 410
 None
ZN  A 802 ( 4.8A)
None
None
 1.15A 6fbvD-4rvwA:
undetectable		 6fbvD-4rvwA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 11 TYR A 196
VAL A 193
GLY A 723
ALA A 701
VAL A 709
 None
 1.39A 6hu9A-4rvwA:
undetectable
6hu9E-4rvwA:
undetectable
6hu9I-4rvwA:
undetectable		 6hu9A-4rvwA:
20.79
6hu9E-4rvwA:
13.81
6hu9I-4rvwA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4rvw ZNUD
(Neisseria
meningitidis) 		5 / 10 TYR A 196
VAL A 193
GLY A 723
ALA A 701
VAL A 709
 None
 1.41A 6hu9L-4rvwA:
undetectable
6hu9P-4rvwA:
undetectable
6hu9T-4rvwA:
undetectable		 6hu9L-4rvwA:
20.79
6hu9P-4rvwA:
13.81
6hu9T-4rvwA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4rvw ZNUD
(Neisseria
meningitidis) 		3 / 3 TRP A 303
ILE A 304
ASP A 305
 None
 0.64A 6i0y7-4rvwA:
undetectable		 6i0y7-4rvwA:
2.51