SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		3 / 3 TRP A   8
VAL A  89
TRP A 189
 None
 1.24A 1c4dA-4rw3A:
undetectable
1c4dB-4rw3A:
undetectable		 1c4dA-4rw3A:
3.52
1c4dB-4rw3A:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 6 LEU A  68
TRP A 119
ASN A 113
PHE A 146
 None
 1.43A 1rukH-4rw3A:
undetectable
1rukL-4rw3A:
undetectable		 1rukH-4rw3A:
21.68
1rukL-4rw3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		5 / 11 LEU A  88
ILE A 130
LEU A 114
ARG A 127
GLY A 126
 None
 1.12A 2bxmA-4rw3A:
undetectable		 2bxmA-4rw3A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 8 ILE A 130
PHE A  91
ARG A  72
LEU A  86
 None
 0.93A 2eilN-4rw3A:
undetectable
2eilW-4rw3A:
undetectable		 2eilN-4rw3A:
20.23
2eilW-4rw3A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		5 / 11 ILE A 172
GLY A 240
ALA A 239
ASP A 238
VAL A 205
 None
 0.98A 2fxdA-4rw3A:
undetectable		 2fxdA-4rw3A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		5 / 12 GLY A 193
ASN A 169
ALA A 208
GLN A 190
GLY A 168
 None
 0.87A 2pkkA-4rw3A:
undetectable		 2pkkA-4rw3A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		5 / 12 GLY A 193
ASN A 169
ALA A 208
GLN A 190
GLY A 168
 None
 0.87A 2pkmA-4rw3A:
undetectable		 2pkmA-4rw3A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 6 ASP A 242
VAL A 241
PHE A 278
PRO A   6
 None
 1.23A 2q6oB-4rw3A:
undetectable		 2q6oB-4rw3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 8 ILE A 130
PHE A  91
ARG A  72
LEU A  86
 None
 0.93A 3ag3N-4rw3A:
undetectable
3ag3W-4rw3A:
undetectable		 3ag3N-4rw3A:
20.23
3ag3W-4rw3A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 8 ILE A 130
PHE A  91
ARG A  72
LEU A  86
 None
 0.94A 3asnN-4rw3A:
undetectable
3asnW-4rw3A:
undetectable		 3asnN-4rw3A:
20.23
3asnW-4rw3A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 5 SER A 167
GLY A 168
THR A  95
ASP A 170
 IPD  A 304 (-3.9A)
None
None
GOL  A 305 (-3.8A)
 1.14A 4eohA-4rw3A:
undetectable		 4eohA-4rw3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		5 / 11 GLY A 240
ALA A 239
ASP A 238
ILE A 252
VAL A 205
 None
 1.03A 4l1aA-4rw3A:
undetectable		 4l1aA-4rw3A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 5 PRO A 249
GLY A  27
ASP A 235
ASP A 254
 None
 1.09A 4n48B-4rw3A:
undetectable		 4n48B-4rw3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 7 ILE A 130
PHE A  91
ARG A  72
LEU A  86
 None
 0.94A 5b3sN-4rw3A:
undetectable
5b3sW-4rw3A:
undetectable		 5b3sN-4rw3A:
20.23
5b3sW-4rw3A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		5 / 12 LEU A  71
LEU A  86
ALA A 128
ILE A 134
LEU A 110
 None
 1.14A 5h8tA-4rw3A:
undetectable		 5h8tA-4rw3A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 7 ILE A 130
PHE A  91
ARG A  72
LEU A  86
 None
 0.91A 5iy5N-4rw3A:
undetectable
5iy5W-4rw3A:
undetectable		 5iy5N-4rw3A:
20.23
5iy5W-4rw3A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 8 ILE A 130
PHE A  91
ARG A  72
LEU A  86
 None
 0.89A 5xdxN-4rw3A:
undetectable
5xdxW-4rw3A:
undetectable		 5xdxN-4rw3A:
20.23
5xdxW-4rw3A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		5 / 10 ILE A 134
LEU A  93
PHE A  91
LEU A 114
ALA A 111
 None
 1.23A 5y7pH-4rw3A:
undetectable		 5y7pH-4rw3A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII
(Loxosceles
intermedia) 		4 / 4 PRO A 135
MET A 245
GLY A 243
VAL A  90
 None
IPD  A 304 ( 3.7A)
None
None
 1.01A 6ak3A-4rw3A:
undetectable		 6ak3A-4rw3A:
13.16