SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 10 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.98A 2aquA-4rweA:
undetectable
2aquA-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 11 VAL A 104
GLY A 101
ALA A 121
LEU A  92
SER A  68
None
1.13A 2bxgA-4rweA:
undetectable
2bxgA-4rweA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 6 LEU A 259
MET A 201
THR A 202
LEU A 205
None
1.07A 2dyrA-4rweA:
undetectable
2dyrJ-4rweA:
undetectable
2dyrA-4rweA:
20.54
2dyrJ-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 6 LEU A 259
MET A 201
THR A 202
LEU A 205
None
1.05A 2eijA-4rweA:
undetectable
2eijJ-4rweA:
undetectable
2eijA-4rweA:
20.54
2eijJ-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 7 LEU A 259
MET A 201
THR A 202
LEU A 205
None
1.05A 2eikA-4rweA:
undetectable
2eikJ-4rweA:
undetectable
2eikA-4rweA:
20.54
2eikJ-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 6 LEU A 259
MET A 201
THR A 202
LEU A 205
None
1.06A 2eilA-4rweA:
undetectable
2eilJ-4rweA:
undetectable
2eilA-4rweA:
20.54
2eilJ-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 6 ILE A 239
MET A 201
THR A 202
LEU A 205
None
0.95A 2einN-4rweA:
undetectable
2einW-4rweA:
undetectable
2einN-4rweA:
20.54
2einW-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.89A 2f80B-4rweA:
undetectable
2f80B-4rweA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 LEU A 204
ASP A 226
ILE A 223
GLY A 241
VAL A 200
None
GOL  A 401 (-3.5A)
GOL  A 401 ( 4.2A)
None
None
1.24A 2o4lA-4rweA:
undetectable
2o4lA-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.85A 2o4sB-4rweA:
undetectable
2o4sB-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.94A 2qakB-4rweA:
undetectable
2qakB-4rweA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.94A 2qhcB-4rweA:
undetectable
2qhcB-4rweA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.99A 2z54A-4rweA:
undetectable
2z54A-4rweA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.93A 2z54B-4rweA:
undetectable
2z54B-4rweA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 6 LEU A 259
MET A 201
THR A 202
LEU A 205
None
1.06A 3abmA-4rweA:
undetectable
3abmJ-4rweA:
undetectable
3abmA-4rweA:
20.54
3abmJ-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 6 ILE A 239
MET A 201
THR A 202
LEU A 205
None
0.83A 3ag1N-4rweA:
undetectable
3ag1W-4rweA:
undetectable
3ag1N-4rweA:
20.54
3ag1W-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 6 LEU A 259
MET A 201
THR A 202
LEU A 205
None
1.08A 3asoA-4rweA:
undetectable
3asoJ-4rweA:
undetectable
3asoA-4rweA:
20.54
3asoJ-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.87A 3cywB-4rweA:
undetectable
3cywB-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.94A 3d1xB-4rweA:
undetectable
3d1xB-4rweA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
1.00A 3d1zA-4rweA:
undetectable
3d1zA-4rweA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.90A 3d20B-4rweA:
undetectable
3d20B-4rweA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 8 PRO A 268
ALA A 272
ALA A 275
ILE A  45
None
0.78A 3dtuC-4rweA:
undetectable
3dtuD-4rweA:
undetectable
3dtuC-4rweA:
19.92
3dtuD-4rweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 111
ALA A 110
ASP A 109
VAL A 104
ALA A  85
None
0.92A 3ekwB-4rweA:
undetectable
3ekwB-4rweA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 ALA A  53
LEU A  27
SER A 273
GLY A  48
GLU A  50
None
1.04A 3g2oB-4rweA:
undetectable
3g2oB-4rweA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
3 / 3 ARG A 106
ILE A  90
THR A 127
None
0.70A 3ia4D-4rweA:
undetectable
3ia4D-4rweA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.89A 3jvyB-4rweA:
undetectable
3jvyB-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.90A 3lzsA-4rweA:
undetectable
3lzsA-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.95A 3lzsB-4rweA:
undetectable
3lzsB-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.95A 3lzuA-4rweA:
undetectable
3lzuA-4rweA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 7 TYR A  70
VAL A 114
VAL A 119
ILE A 100
None
1.23A 3ms9B-4rweA:
undetectable
3ms9B-4rweA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.96A 3ndtC-4rweA:
undetectable
3ndtC-4rweA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.93A 3ndwA-4rweA:
undetectable
3ndwA-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.95A 3ndxA-4rweA:
undetectable
3ndxA-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 10 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.98A 3nu6B-4rweA:
undetectable
3nu6B-4rweA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.95A 3tkgA-4rweA:
undetectable
3tkgA-4rweA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
1.01A 3tkgB-4rweA:
undetectable
3tkgB-4rweA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
1.00A 3tkgC-4rweA:
undetectable
3tkgC-4rweA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.88A 3tkwA-4rweA:
undetectable
3tkwA-4rweA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 6 ILE A 239
MET A 201
THR A 202
LEU A 205
None
1.02A 3wg7N-4rweA:
undetectable
3wg7W-4rweA:
undetectable
3wg7N-4rweA:
20.54
3wg7W-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 11 ASP A  96
ILE A 100
GLY A  99
VAL A 114
GLY A 123
None
1.09A 4ac9B-4rweA:
4.4
4ac9C-4rweA:
5.1
4ac9B-4rweA:
22.40
4ac9C-4rweA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 9 ASP A  96
ILE A 100
GLY A  99
VAL A 114
GLY A 123
None
1.14A 4acaB-4rweA:
4.6
4acaC-4rweA:
4.1
4acaB-4rweA:
22.40
4acaC-4rweA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 4 PHE A 215
VAL A 240
ALA A 216
PHE A 260
None
1.40A 4f3tA-4rweA:
7.2
4f3tA-4rweA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 11 ILE A 156
ALA A 228
ALA A 229
ILE A 211
VAL A 214
None
0.81A 4h1nA-4rweA:
undetectable
4h1nA-4rweA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.90A 4hlaA-4rweA:
undetectable
4hlaA-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 11 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.90A 4hlaB-4rweA:
undetectable
4hlaB-4rweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 4 PHE A 215
VAL A 240
ALA A 216
PHE A 260
None
1.39A 4w5qA-4rweA:
7.3
4w5qA-4rweA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 4 PHE A 215
VAL A 240
ALA A 216
PHE A 260
None
1.44A 4w5rA-4rweA:
7.1
4w5rA-4rweA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 4 PHE A 215
VAL A 240
ALA A 216
PHE A 260
None
1.46A 4w5tA-4rweA:
7.0
4w5tA-4rweA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 4 PHE A 215
VAL A 240
ALA A 216
PHE A 260
None
1.43A 4z4gA-4rweA:
7.1
4z4gA-4rweA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 4 PHE A 215
VAL A 240
ALA A 216
PHE A 260
None
1.41A 5ki6A-4rweA:
7.0
5ki6A-4rweA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 6 ILE A 239
MET A 201
THR A 202
LEU A 205
None
0.97A 5z86N-4rweA:
undetectable
5z86W-4rweA:
undetectable
5z86N-4rweA:
20.54
5z86W-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
4 / 6 ILE A 239
MET A 201
THR A 202
LEU A 205
None
0.97A 5zcoN-4rweA:
undetectable
5zcoW-4rweA:
undetectable
5zcoN-4rweA:
20.54
5zcoW-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 ALA A 225
PRO A 220
GLY A 192
ALA A 229
PHE A 237
None
1.36A 5zvgA-4rweA:
2.0
5zvgA-4rweA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 ALA A 225
PRO A 220
GLY A 192
ALA A 229
PHE A 237
None
1.34A 5zvgB-4rweA:
undetectable
5zvgB-4rweA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 VAL A 119
THR A 129
PHE A  42
PHE A  41
VAL A  34
None
None
None
CL  A 402 ( 3.8A)
None
1.36A 6a93B-4rweA:
undetectable
6a93B-4rweA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 196
ALA A 190
ILE A 223
VAL A 214
ILE A 156
None
None
GOL  A 401 ( 4.2A)
None
None
0.93A 6difB-4rweA:
undetectable
6difB-4rweA:
17.37